y 27632 and Disease Models, Animal

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Kidney Diseases; Kidney Tubules; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases

Topics: Animals; Antihypertensive Agents; Binding Sites; Computer Simulation; Disease Models, Animal; Hypertension; Protein Kinase Inhibitors; Pyrimidines; Rats; rho-Associated Kinases; Structure-Activity Relationship; Triazines

Topics: Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; Structure-Activity Relationship

Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Animals; Brain; Disease Models, Animal; Huntingtin Protein; Huntington Disease; Mice; Protein Kinase Inhibitors; rho-Associated Kinases

Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Isoflurane; Morpholines; Phosphatidylinositol 3-Kinases; Potassium Chloride; Pyridines; Rats, Inbred OLETF; Rats, Wistar; rho-Associated Kinases; Sevoflurane; Vasoconstriction

Topics: Amides; Animals; Behavior, Animal; Carbon Monoxide Poisoning; Cognitive Dysfunction; Disease Models, Animal; Neurotoxicity Syndromes; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; Signal Transduction

Topics: Amides; Animals; Cell Survival; Disease Models, Animal; Gene Expression Regulation; Humans; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Male; Mice; Neutrophils; Pyridines; rho-Associated Kinases

Topics: Amides; Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cornea; Corneal Injuries; Culture Media, Conditioned; Disease Models, Animal; Endothelial Progenitor Cells; Endothelium, Corneal; Fetal Blood; Gene Expression Profiling; Gene Expression Regulation; Humans; Immunohistochemistry; Intraocular Pressure; Microscopy, Confocal; Oligonucleotide Array Sequence Analysis; Protein Kinase Inhibitors; Pyridines; Rabbits; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; Stem Cell Transplantation; Transplantation, Heterologous; Wound Healing; Zonula Occludens-1 Protein

Topics: Amides; Animals; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Humans; Mice; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Retinal Pigment Epithelium; Transforming Growth Factor beta1; Vitreoretinopathy, Proliferative

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Coronary Vessels; Disease Models, Animal; Female; Fetal Growth Retardation; Male; Mesenteric Arteries; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy; Pyridines; Rats, Wistar; rho-Associated Kinases

Topics: Amides; Analysis of Variance; Angiotensin II; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Formins; Male; Microfilament Proteins; Myocytes, Cardiac; Phosphorylation; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; Signal Transduction; Up-Regulation

Topics: Amides; Amniotic Fluid; Animals; Cell Adhesion Molecules; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Disease Models, Animal; Down Syndrome; Epidermal Cells; Epidermal Growth Factor; Epidermis; Exome Sequencing; Extracellular Matrix Proteins; Female; Fetal Therapies; Fetofetal Transfusion; Humans; Induced Pluripotent Stem Cells; Karyotyping; Keratin-14; Keratinocytes; Meningomyelocele; Polymorphism, Single Nucleotide; Pregnancy; Pyridines; Rats; Skin; Transcription Factors

Topics: Amides; Animals; Asthma; Disease Models, Animal; Guinea Pigs; Male; Plethysmography, Whole Body; Pyridines; Respiration; Respiratory Physiological Phenomena; rho-Associated Kinases

Topics: Alcohol Drinking; Alcoholism; Amides; Animals; Central Amygdaloid Nucleus; Central Nervous System Depressants; Conditioning, Psychological; Disease Models, Animal; Ethanol; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Pyridines; Synaptic Transmission

Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Cell Differentiation; Cell Polarity; Cerebrovascular Circulation; Cerebrovascular Disorders; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Homeodomain Proteins; Interleukin-17; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurovascular Coupling; Phosphorylation; Pyridines; Sodium Chloride, Dietary; Th17 Cells

Topics: Actin Cytoskeleton; Actins; Agrin; Amides; Animals; Cell Movement; Disease Models, Animal; Embryo, Nonmammalian; Enzyme Inhibitors; Gene Expression Regulation; Humans; Intermediate Filaments; Membrane Proteins; Mice; Motor Neurons; Muscle Weakness; Myasthenic Syndromes, Congenital; Myosins; Nerve Growth Factor; Neuromuscular Junction; Protein Transport; Pyridines; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Tubulin; Zebrafish

Topics: Amides; Aminoquinolines; Animals; Antioxidants; Arterial Pressure; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Glomerular Filtration Rate; Heart Rate; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidative Stress; Proteinuria; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; Rats, Sprague-Dawley; Reactive Oxygen Species; rho GTP-Binding Proteins; rho-Associated Kinases; Spin Labels; Time Factors; Ureteral Obstruction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Hydroxyphenethylamine; Amides; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Female; HEK293 Cells; Humans; Male; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyridines; rho-Associated Kinases; Signal Transduction

Topics: Adult; Amides; Animals; Cohort Studies; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Kaplan-Meier Estimate; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Peroxidase; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Vascular Remodeling; Vasoconstriction

Topics: Amides; Animals; Biomarkers; Blood Glucose; Cell Differentiation; Cell Lineage; Cell Proliferation; Diet, High-Fat; Disease Models, Animal; Enteroendocrine Cells; Glucagon-Like Peptide 1; Glucose Intolerance; Hypoglycemic Agents; Ileum; Insulin; Insulin Resistance; Male; Mice, Inbred C57BL; Mice, Transgenic; Organoids; Phenotype; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Stem Cells; Time Factors; Tissue Culture Techniques

Topics: Amides; Animals; Apoptosis; Cell Adhesion; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Models, Animal; Graft Survival; Humans; Induced Pluripotent Stem Cells; Mice, Inbred NOD; Mice, SCID; Myocardial Contraction; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Phenotype; Protein Kinase Inhibitors; Pyridines; Recovery of Function; rho-Associated Kinases; Time Factors

Topics: Amides; Animals; bcl-2-Associated X Protein; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Learning; Male; Memory; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; rho-Associated Kinases; Signal Transduction

Topics: Amides; Animals; Cell Count; Cold Injury; Corneal Injuries; Disease Models, Animal; Dogs; Endothelial Cells; Endothelium, Corneal; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Wound Healing

Topics: Amides; Animals; Apoptosis; Blood Pressure; Carotid Body; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Hypertension; Hypoxia; Male; NADPH Oxidases; Neuronal Plasticity; Onium Compounds; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; rho-Associated Kinases; Signal Transduction

Topics: Amides; Amyotrophic Lateral Sclerosis; Animals; Axons; Disease Models, Animal; Enzyme Inhibitors; Female; Male; Mice; Mice, Transgenic; Nerve Regeneration; Pyridines; rho-Associated Kinases; Sciatic Neuropathy; Superoxide Dismutase

Topics: Actins; Amides; Animals; Axons; Cofilin 1; Disease Models, Animal; Enzyme Inhibitors; Lim Kinases; Neuronal Plasticity; Pyridines; Retina; Retinal Detachment; Retinal Rod Photoreceptor Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Swine

Topics: Alkaloids; Amides; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cell Proliferation; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Interleukins; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Pyridines; Quinolizines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Treatment Outcome

Topics: Amides; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Humans; Induced Pluripotent Stem Cells; Mice; Myocardial Infarction; Myocytes, Cardiac; Protein Subunits; Pyridines; rho-Associated Kinases; Troponin; Verapamil

Topics: Amides; Animals; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Knockout; Pyridines; Receptor, EphA4; rho-Associated Kinases; Rotarod Performance Test; Signal Transduction; Stroke; Stroke Rehabilitation

Topics: Administration, Topical; Aged; Amides; Animals; Cell Count; Corneal Edema; Corneal Endothelial Cell Loss; Disease Models, Animal; Endothelium, Corneal; Enzyme Inhibitors; Eye Injuries; Female; Humans; Macaca fascicularis; Male; Middle Aged; Ophthalmic Solutions; Pyridines; rho-Associated Kinases; Sodium-Potassium-Exchanging ATPase; Wound Healing; Wounds, Nonpenetrating; Zonula Occludens-1 Protein

Topics: Actins; Amides; Analysis of Variance; Animals; Burns; Capillary Permeability; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

Topics: Amides; Animals; Apoptosis; Bacterial Load; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cecum; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Forkhead Transcription Factors; HMGB1 Protein; Immunity, Cellular; Inflammation; Interleukin-17; Interleukin-2 Receptor alpha Subunit; Male; Mice; Mice, Inbred C57BL; Pyridines; rho-Associated Kinases; Sepsis; Spleen

Topics: Administration, Topical; Amides; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Humans; Keratinocytes; Mice; Pyridines; rho-Associated Kinases; Wound Healing

Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Ovariectomy; Pyridines; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Tetrazoles; Tyrosine 3-Monooxygenase

Topics: Amides; Animals; Animals, Newborn; Antihypertensive Agents; Blotting, Western; Disease Models, Animal; Female; Hyperoxia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Time Factors

Topics: Amides; Animals; Bronchoalveolar Lavage Fluid; Chemotaxis; Cytoprotection; Disease Models, Animal; Lung; Lung Injury; Lung Transplantation; Macrophages; Neutrophil Infiltration; Permeability; Protein Kinase Inhibitors; Pulmonary Edema; Pyridines; Rats, Inbred Lew; Reperfusion Injury; rho-Associated Kinases; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha

Topics: Administration, Inhalation; Amides; Analysis of Variance; Animals; Chronic Disease; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Guinea Pigs; Immunoglobulin G; Lung; Male; Nitric Oxide Synthase Type II; Ovalbumin; Pneumonia; Pyridines; rho-Associated Kinases; Stress, Mechanical; Tissue Inhibitor of Metalloproteinase-1

Topics: Amides; Animals; Benzimidazoles; Calcium; Dilatation, Pathologic; Disease Models, Animal; Hemodynamics; Injections, Intraperitoneal; Ischemic Preconditioning; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Male; Mesenteric Artery, Superior; Potassium Channels; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; rho-Associated Kinases; rhoA GTP-Binding Protein; Sensitivity and Specificity; Shock, Hemorrhagic; Signal Transduction; Survival Rate

Topics: Actins; Amides; Animals; Antihypertensive Agents; Benzoates; Conjunctiva; Disease Models, Animal; Focal Adhesions; Hyperemia; Intraocular Pressure; Male; Ocular Hypertension; Protein Kinase Inhibitors; Pyridines; Rabbits; rho-Associated Kinases; Tonometry, Ocular; Trabecular Meshwork; Vinculin

Topics: Aged; Amides; Animals; Bone Morphogenetic Proteins; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Disease Models, Animal; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Heterografts; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Metastasis; Pyridines; rho-Associated Kinases; Signal Transduction; Smad4 Protein; Survival Rate

Topics: Amides; Animals; Antineoplastic Agents; Blood Platelets; Bone Marrow; Boronic Acids; Bortezomib; Colony-Forming Units Assay; Disease Models, Animal; Male; Megakaryocyte Progenitor Cells; Megakaryocytes; Mice; Multiple Myeloma; Platelet Count; Pyrazines; Pyridines; rho-Associated Kinases; Thrombocytopenia; Thrombopoiesis; Thrombopoietin

Topics: Amides; Animals; Arterial Pressure; Cells, Cultured; Chemistry, Pharmaceutical; Choline Deficiency; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Hepatic Stellate Cells; Hypotension; Liposomes; Liver; Liver Circulation; Male; Portal Pressure; Protein Kinase Inhibitors; Pyridines; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Amides; Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Chemotaxis; Cisplatin; Coculture Techniques; Cytoprotection; Disease Models, Animal; Hepatitis A Virus Cellular Receptor 1; Inflammation Mediators; Kidney Tubules; Macrophages; Membrane Proteins; Mice, Inbred C57BL; Nephritis; Neutrophil Infiltration; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction; T-Lymphocytes; Time Factors

Topics: Amides; Animals; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Male; Myosin-Light-Chain Phosphatase; Ouabain; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases

Topics: Amides; Animals; Apoptosis; Caspase 3; Disease Models, Animal; Electroretinography; Female; Intravitreal Injections; Photoreceptor Cells; Protective Agents; Protein Kinase Inhibitors; Pyridines; Rats; Retina; Retinitis Pigmentosa; rho-Associated Kinases

Topics: Adipokines; Amides; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Eye Proteins; Myocytes, Cardiac; Pyridines; Rats; Tumor Necrosis Factor-alpha

Topics: Airway Remodeling; Amides; Animals; Asthma; Chronic Disease; Disease Models, Animal; Drug Synergism; Enzyme Inhibitors; Glucocorticoids; Guinea Pigs; Inflammation; Lung; Pyridines

Topics: Amides; Animals; Cell Proliferation; Cells, Cultured; Corneal Injuries; Disease Models, Animal; Endothelium, Corneal; Enzyme Inhibitors; Humans; Pilot Projects; Pyridines; Rabbits; rho-Associated Kinases; Wound Healing

Topics: Actin Depolymerizing Factors; Amides; Animals; Atorvastatin; Binding Sites; Cerebral Hemorrhage; Databases, Chemical; Databases, Protein; Disease Models, Animal; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyridines; Pyrroles; rho-Associated Kinases; Signal Transduction; Structure-Activity Relationship; Zebrafish

Topics: Amides; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anoctamin-1; Basilar Artery; Cells, Cultured; Chloride Channels; Disease Models, Animal; Evoked Potentials; Hypertension; Male; Muscle, Smooth, Vascular; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vasoconstriction

Topics: Amides; Animals; Antiparkinson Agents; Basal Ganglia; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Pyridines; Rats; rho-Associated Kinases

Topics: Amides; Amiloride; Animals; Cation Transport Proteins; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypoxia; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Vascular Remodeling

Topics: Amides; Animals; Cats; Cell Count; Cell- and Tissue-Based Therapy; Cells, Cultured; Corneal Pachymetry; Disease Models, Animal; Endothelium, Corneal; Enzyme Inhibitors; Graft Survival; Injections, Intraocular; Microscopy, Electron; Pyridines; Sodium-Potassium-Exchanging ATPase; Transplantation, Homologous; Wound Healing; Zonula Occludens-1 Protein

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Amides; Animals; Brain; Carrier Proteins; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Aggregates; Protein Kinase Inhibitors; Psychomotor Performance; Pyridines; Recognition, Psychology; Time Factors; Tyrosine 3-Monooxygenase

Topics: Actins; Amides; Animals; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Middle Cerebral Artery; Muscle, Smooth; Neutrophils; Ovariectomy; Pyridines; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Tissue Plasminogen Activator; Tyrosine

Topics: Amides; Animals; Cardiac Myosins; Disease Models, Animal; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Myosin Light Chains; Phosphorylation; Protein Kinase C-alpha; Pyridines; rac1 GTP-Binding Protein; Retinal Detachment; Retinal Rod Photoreceptor Cells; rhoA GTP-Binding Protein; Signal Transduction; Sus scrofa; Swine; Synapses

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chemokine CCL2; Diabetic Nephropathies; Disease Models, Animal; Endothelial Cells; Glycation End Products, Advanced; Inflammation; Intercellular Adhesion Molecule-1; Kidney Glomerulus; Mice; Mice, Mutant Strains; Protein Kinase Inhibitors; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anticonvulsants; Blotting, Western; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Protein Kinase Inhibitors; Protein Transport; Pyridines; Reflex; rho-Associated Kinases; Seizures

Topics: Amides; Animals; Autonomic Pathways; Blood Vessels; Brain Stem; Cytoskeletal Proteins; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Norepinephrine; Organ Size; Pyridines; rho-Associated Kinases; Sympathetic Nervous System; Up-Regulation; Vasoconstriction

Topics: Amides; Animals; Animals, Newborn; Blotting, Western; Cell Culture Techniques; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Hypoxia; Infant, Newborn; Microscopy, Fluorescence; Oxidative Stress; Oxygen; Plasmids; Pyridines; Rats; Rats, Long-Evans; Receptors, Lysophosphatidic Acid; Retinal Degeneration; Retinal Ganglion Cells; Retinopathy of Prematurity; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Transfection

Topics: Acetylcholine; Amides; Anesthetics, Inhalation; Animals; Asthma; Bronchi; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Isoflurane; Male; Muscle Relaxation; Muscle, Smooth; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

Topics: Amides; Animals; Calcium; Calcium Chloride; Disease Models, Animal; Hypertension; Male; Mesenteric Arteries; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Pyridines; Rats; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction

Topics: Amides; Analysis of Variance; Animals; Blotting, Western; Cyclic GMP; Disease Models, Animal; Endotoxemia; Lipopolysaccharides; Male; Mesenteric Arteries; Nitric Oxide; Phosphorylation; Probability; Pyridines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; Sensitivity and Specificity; Signal Transduction; Up-Regulation; Vasoconstriction; Vasodilation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Endothelium, Vascular; Muscle, Smooth; Nitric Oxide; Pyridines; Rats; rho-Associated Kinases; Sensitivity and Specificity; Shock, Septic; Vasoconstriction; Vasodilation

Topics: Amides; Animals; Brain; Cell Count; Disease Models, Animal; Dyskinesias; Enzyme Inhibitors; Female; Half-Life; Huntingtin Protein; Huntington Disease; Longevity; Mice; Mice, Transgenic; Motor Activity; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Pyridines; Random Allocation; rho-Associated Kinases; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Airway Remodeling; Amides; Animals; Animals, Newborn; Antihypertensive Agents; Becaplermin; Body Weight; Chronic Disease; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperoxia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Muscle, Smooth, Vascular; Organ Size; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyridines; Rats; Receptor, Platelet-Derived Growth Factor beta; rho-Associated Kinases; Vascular Resistance

Topics: Amides; Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Nerve Regeneration; Neural Conduction; Peripheral Nervous System Diseases; Pyridines; rho-Associated Kinases; Sural Nerve; Touch Perception

Topics: Amides; Animals; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscular Atrophy, Spinal; Neuromuscular Junction; Protein Kinase Inhibitors; Pyridines; rhoA GTP-Binding Protein; Spinal Cord; Survival; Survival of Motor Neuron 1 Protein

Topics: Acute Disease; Amides; Animals; Blood Glucose; Chromatography, Gel; Disease Models, Animal; Ficoll; Fluorescein-5-isothiocyanate; Glomerular Filtration Rate; Glucose Solution, Hypertonic; Hyperglycemia; Infusions, Intravenous; Kidney Glomerulus; Male; Mannitol; Microscopy, Electron, Transmission; Models, Biological; Osmolar Concentration; Osmotic Pressure; Permeability; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Saline Solution, Hypertonic; Time Factors

Topics: Amides; Animals; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Disease Models, Animal; Glioma; Mice; Mice, Transgenic; Platelet-Derived Growth Factor; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein

Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Soluble Guanylyl Cyclase; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; ADP Ribose Transferases; Amides; Animals; Botulinum Toxins; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Female; Male; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Norepinephrine; p21-Activated Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyridines; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Shock, Hemorrhagic; Signal Transduction; Time Factors; Vasoconstriction; Vasoconstrictor Agents

Topics: Amides; Angiotensin II; Animals; Base Sequence; Cell Transdifferentiation; Chlorocebus aethiops; Collagen; Collagen Type I; COS Cells; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Male; Mice; Mice, Knockout; Molecular Sequence Data; Myocardial Infarction; Myocardium; Myocytes, Smooth Muscle; Phenotype; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta1; Ventricular Remodeling

Topics: Amides; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethanol; Female; Lipopolysaccharides; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Phagocytosis; Pneumonia; Pyridines; Respiratory Distress Syndrome; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein

Topics: Amides; Animals; Caustics; Collagen; Disease Models, Animal; Enzyme Inhibitors; Esophageal Stenosis; Esophagus; Hydroxyproline; Male; Malondialdehyde; Pantothenic Acid; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Hydroxide; Vitamin B Complex

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling

Topics: Amides; Animals; Complement C3; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type III; Pain Threshold; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Spinal Cord; Streptozocin; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anti-Infective Agents, Local; Cells, Cultured; Chlorhexidine; Disease Models, Animal; Enzyme Inhibitors; Epithelium; Humans; Immunoenzyme Techniques; Male; Neovascularization, Pathologic; Peritoneal Fibrosis; Pleural Cavity; Pyridines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A

Topics: Amides; Animals; Brain Ischemia; Cyclin-Dependent Kinase 5; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neuroprotective Agents; Phosphorylation; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Spatial Behavior; tau Proteins

Topics: Amides; Animals; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Plant Extracts; Pyridines; Random Allocation; Real-Time Polymerase Chain Reaction; Reference Values; RNA, Messenger; Sensitivity and Specificity; Transplantation, Heterologous; Urokinase-Type Plasminogen Activator

Topics: Amides; Animals; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enterocolitis, Necrotizing; Enzyme Inhibitors; Hypoxia; Intestinal Mucosa; Intestines; Malondialdehyde; Nitric Oxide; Nitrogen; Oxygen; Pyridines; Random Allocation; Rats; Rats, Wistar

Topics: Amides; Animals; Animals, Newborn; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Intravitreal Injections; Mice; Mice, Inbred C57BL; Oxygen; Pyridines; Retina; Retinal Neovascularization; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Treatment Outcome

Topics: Amides; Animals; Cytoskeletal Proteins; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GTPase-Activating Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Intellectual Disability; Mice; Nuclear Proteins; Patch-Clamp Techniques; Pyridines; rho-Associated Kinases; Synaptic Transmission

Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cell Proliferation; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocytes, Smooth Muscle; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Blood Glucose; Calcium; Coronary Vessels; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Middle Cerebral Artery; Nitric Oxide; Protein Kinase C; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases

Topics: Amides; Animals; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Hypercholesterolemia; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder

Topics: Amides; Animals; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Erectile Dysfunction; Male; Nitric Oxide; Penile Erection; Penis; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Up-Regulation

Topics: Amides; Animals; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Erectile Dysfunction; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Orchiectomy; Penis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Testosterone; Time Factors

Topics: Amides; Animals; Disease Models, Animal; Erectile Dysfunction; Humans; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Penile Erection; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein

Topics: Amides; Animals; Animals, Genetically Modified; Biological Assay; Cell Death; COS Cells; Disease Models, Animal; Down-Regulation; Drosophila melanogaster; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Humans; Huntingtin Protein; Inclusion Bodies; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Neurodegenerative Diseases; Nuclear Proteins; Peptides; Photoreceptor Cells, Invertebrate; Protein Folding; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Trinucleotide Repeat Expansion

Topics: Amides; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Antimetabolites; Becaplermin; Bromodeoxyuridine; Cell Division; Cell Movement; Cholesterol; Coronary Vessels; Disease Models, Animal; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Femoral Artery; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Models, Cardiovascular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin-Light-Chain Kinase; Myosins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-sis; Pyridines; rho-Associated Kinases; Statistics as Topic; Swine; Time Factors; Tunica Intima

Topics: Alanine Transaminase; Amides; Animals; Aspartate Aminotransferases; Blood Pressure; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Liver; Liver Diseases; Male; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Administration, Oral; Amides; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome; Vasodilator Agents

Topics: Administration, Intranasal; Aluminum Hydroxide; Amides; Animals; Australia; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Bronchoconstriction; Disease Models, Animal; Female; Hypersensitivity; Injections, Intraperitoneal; Intracellular Signaling Peptides and Proteins; Lung; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Protein Serine-Threonine Kinases; Pulmonary Eosinophilia; Pyridines; rho-Associated Kinases

Topics: Amides; Animals; Benzoquinones; Disease Models, Animal; Drosophila; Drug Therapy, Combination; Female; Huntington Disease; Hydroxamic Acids; Lactams, Macrocyclic; Nerve Degeneration; Nerve Tissue Proteins; Nuclear Proteins; Pyridines; Quinones; Vorinostat

Topics: Amides; Animals; Cells, Cultured; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; Female; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Mice; Mice, Inbred C3H; Obstetric Labor, Premature; Pregnancy; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Tocolytic Agents

Topics: Amides; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Blotting, Western; Brain Injuries; Bromodeoxyuridine; Butadienes; Cell Count; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Colforsin; Cyclin D1; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Microglia; Nitriles; Oligopeptides; Pyridines; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombin; Time Factors

Topics: Actin Depolymerizing Factors; Amides; Analysis of Variance; Animals; Axons; Behavior, Animal; Biotin; Blotting, Western; Cholera Toxin; Dextrans; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Motor Activity; Myosin-Light-Chain Phosphatase; Nerve Regeneration; Pain Measurement; Phosphorylation; Protein Serine-Threonine Kinases; Psychomotor Performance; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Recovery of Function; rho-Associated Kinases; Rotarod Performance Test; Spinal Cord Injuries

Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Southern; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cell Communication; Chemokines, CXC; Chemotaxis, Leukocyte; Disease Models, Animal; Endothelial Cells; Endotoxemia; Hepatic Artery; Hepatocytes; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; Tumor Necrosis Factor-alpha

Topics: Amides; Anal Canal; Animals; Disease Models, Animal; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Hypertonia; Muscle Relaxation; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Tetrodotoxin; Treatment Outcome

Topics: Amides; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Immunosuppressive Agents; Intracellular Signaling Peptides and Proteins; Liver Neoplasms, Experimental; Liver Transplantation; Male; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred BUF; rho-Associated Kinases; Signal Transduction; Tacrolimus

Topics: Amides; Animals; Baroreflex; Basilar Artery; Calcium; Disease Models, Animal; Hypertension; Intracellular Signaling Peptides and Proteins; Mechanotransduction, Cellular; Pressoreceptors; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoconstriction

Topics: Alloxan; Amides; Animals; Blotting, Western; Diabetes Mellitus, Experimental; Disease Models, Animal; Erectile Dysfunction; Hypogonadism; Intracellular Signaling Peptides and Proteins; Male; Penis; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Streptozocin; Testosterone; Up-Regulation

Topics: Alanine Transaminase; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aspartate Aminotransferases; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Choline Deficiency; Disease Models, Animal; DNA Damage; Fatty Liver; Liver; Liver Cirrhosis; Male; Organ Size; Oxidative Stress; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Tetrazoles; Time Factors; Tumor Necrosis Factor-alpha

Topics: Amides; Animals; Antihypertensive Agents; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Kidney Glomerulus; Membrane Proteins; Mice; Nephrosis; Podocytes; Puromycin Aminonucleoside; Pyridines; rho-Associated Kinases

Topics: Amides; Animals; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Enzyme Inhibitors; Female; Lung; Mice; Mice, Inbred BALB C; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Ovalbumin; Perfusion; Phosphorylation; Pyridines; rho-Associated Kinases

Topics: Acute Disease; Allergens; Amides; Animals; Asthma; Disease Models, Animal; Enzyme Inhibitors; Guinea Pigs; Inflammation; Male; Neutrophils; Pyridines; rho-Associated Kinases; Time Factors

Topics: Amides; Animals; Cytokines; Disease Models, Animal; Echocardiography; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Male; Microscopy, Electron; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Respiratory Function Tests; Ventilators, Mechanical

Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cerebral Arteries; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; Species Specificity; Vasodilator Agents; Vasomotor System

Topics: Amides; Animals; Antibodies; Disease Models, Animal; Enzyme Inhibitors; Graft Rejection; Graft Survival; Heart Transplantation; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-6; Leukocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Models, Cardiovascular; Pyridines; Transplantation, Heterotopic; Transplantation, Homologous; Vascular Cell Adhesion Molecule-1

Topics: Amides; Animals; Basilar Artery; Blood; Cerebral Angiography; Cerebrospinal Fluid; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; In Vitro Techniques; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Lysophospholipids; Male; Protein Serine-Threonine Kinases; Pyridines; Radioligand Assay; rho-Associated Kinases; Sphingosine; Vascular Patency; Vasoconstriction; Vasospasm, Intracranial

Topics: Amides; Animals; Bacterial Toxins; Base Sequence; Blood-Brain Barrier; Brain; Cells, Cultured; Cerebrovascular Circulation; Cytotoxins; Disease Models, Animal; DNA Primers; Endothelium, Vascular; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Humans; Infant, Newborn; Meningitis, Bacterial; Mutagenesis, Site-Directed; Pyridines; Rats; Recombinant Proteins; rhoA GTP-Binding Protein; Transfection