y 27632 and Anoxemia

Topics: Adult; Amides; Animals; Cohort Studies; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Kaplan-Meier Estimate; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Peroxidase; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Vascular Remodeling; Vasoconstriction

Topics: Amides; Animals; Apoptosis; Blood Pressure; Carotid Body; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Hypertension; Hypoxia; Male; NADPH Oxidases; Neuronal Plasticity; Onium Compounds; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; rho-Associated Kinases; Signal Transduction

Topics: Adenosine Triphosphate; Adult; Aged; Amides; Erythrocytes; Female; Humans; Hypoxia; Male; Middle Aged; Pyridines; Vasodilation; Young Adult

Topics: Amides; Animals; Ascorbic Acid; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Male; Nitric Oxide Synthase Type III; Piperidines; Pulmonary Artery; Pyridines; Rats; Sildenafil Citrate; Vascular Endothelial Growth Factors; Xanthines

Topics: Amides; Amiloride; Animals; Cation Transport Proteins; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypoxia; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Vascular Remodeling

Topics: Amides; Animals; Calcium; Enzyme Inhibitors; Hypoxia; Indoles; Male; Models, Animal; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Pulmonary Artery; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Sulfonamides; Vasoconstriction

Topics: Amides; Animals; Antihypertensive Agents; Cell Proliferation; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Mice, Inbred C57BL; Pulmonary Artery; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2A; rho-Associated Kinases; Serotonin Plasma Membrane Transport Proteins; Signal Transduction

Topics: Amides; Animals; Animals, Newborn; Blotting, Western; Cell Culture Techniques; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Hypoxia; Infant, Newborn; Microscopy, Fluorescence; Oxidative Stress; Oxygen; Plasmids; Pyridines; Rats; Rats, Long-Evans; Receptors, Lysophosphatidic Acid; Retinal Degeneration; Retinal Ganglion Cells; Retinopathy of Prematurity; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Transfection

Topics: Actins; Amides; Animals; Cell Proliferation; Endothelin-1; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Phenotype; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Thiazines; Time Factors

Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Soluble Guanylyl Cyclase; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling

Topics: Amides; Animals; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enterocolitis, Necrotizing; Enzyme Inhibitors; Hypoxia; Intestinal Mucosa; Intestines; Malondialdehyde; Nitric Oxide; Nitrogen; Oxygen; Pyridines; Random Allocation; Rats; Rats, Wistar

Topics: Amides; Animals; Blood Pressure; Chromones; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Indoles; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Morpholines; Nifedipine; Potassium Chloride; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents

Topics: Amides; Animals; Cardiomegaly; Enzyme Inhibitors; Hematocrit; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lung; Male; Mice; Mice, Inbred C57BL; Perfusion; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; rho-Associated Kinases; Vasoconstriction; Ventricular Dysfunction, Right; Ventricular Function, Right

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Administration, Oral; Amides; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome; Vasodilator Agents

Topics: Amides; Animals; Blood Pressure; Capillaries; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Lung; Male; Neovascularization, Physiologic; Oxygen Consumption; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Vascular Endothelial Growth Factor A; Vascular Resistance; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Blotting, Western; Brain Ischemia; Cattle; Cell Line; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyridines; Regional Blood Flow; rho-Associated Kinases; RNA, Messenger; Stroke; Time Factors; Umbilical Veins; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction

Topics: Acetylcholine; Alkaloids; Amides; Animals; Benzophenanthridines; Cerebral Arteries; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Phenanthridines; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Superoxides; Triazenes; Vasodilation; Vasodilator Agents

Topics: Amides; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Fetus; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Hypoxia; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Oxygen; Pregnancy; Protein Serine-Threonine Kinases; Pulmonary Artery; Pulmonary Circulation; Pyridines; rho-Associated Kinases; RNA, Messenger; Sheep; Vasodilation

Topics: Administration, Inhalation; Amides; Animals; Animals, Newborn; Bleomycin; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Macrophages; Nitric Oxide; Nitric Oxide Donors; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right

Topics: Amides; Animals; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Peptides, Cyclic; Perfusion; Potassium Chloride; Pulmonary Artery; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Vasoconstriction

Topics: Amides; Animals; Cytokines; Disease Models, Animal; Echocardiography; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Male; Microscopy, Electron; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Respiratory Function Tests; Ventilators, Mechanical

Topics: Amides; Animals; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypoxia; Intracellular Signaling Peptides and Proteins; Lung; Male; Perfusion; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Vasoconstriction