Page last updated: 2024-09-03

y 27632 and Aging

y 27632 has been researched along with Aging in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (45.00)29.6817
2010's9 (45.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Huang, S; Jin, F; Liu, Y; Qi, F; Yang, S1
Fisher, ES; Manley, L; Temple, S; Wang, Y; Zhao, X; Zuloaga, K1
Chess-Williams, R; Lim, I; Sellers, D1
Cohen, H; Horvath, S; Lu, AT; Raj, K1
He, L; Kang, S; Ling, QL; Liu, JG; Liu, WT; Liu, Y; Lu, B1
Seawright, JW; Trache, A; Wilson, E; Woodman, CR1
Cherasse, Y; Deguchi, Y; Furuyashiki, T; Harada, M; Lazarus, M; Narumiya, S; Sekiguchi, M; Shinohara, R; Urade, Y; Watanabe, D; Yamada, D1
Cheung, J; Gossan, N; Hughes, A; McConnell, J; Meng, QJ; Olabi, S; Pekovic-Vaughan, V; Streuli, CH; Wang, P; Williams, J; Yang, N1
Engelberts, D; Ivanovska, J; Jankov, RP; Kantores, C; Kavanagh, BP; McNamara, PJ; Xu, EZ1
Camello, PJ; Camello-Almaraz, C; Gomez-Pinilla, PJ; Macias, B; Pascua, P; Pozo, MJ; Tresguerres, JA1
Hoshino, Y; Ishigami, A; Machii, H; Misaka, T; Miyata, M; Mizukami, H; Saitoh, S; Takeishi, Y; Yamada, S1
Jin, L; Linder, AE; Mills, TM; Webb, RC1
Fujikawa, A; Katsuura, G; Komai, S; Manabe, T; Niisato, K; Noda, M; Sakaguchi, G; Shintani, T; Watanabe, E1
Cogolludo, A; Lodi, F; Moreno, L; Perez-Vizcaino, F; Tamargo, J1
Hester, RL; Naik, JS; Xiang, L1
Belik, J; Kerc, E; Pato, MD1
Bivalacqua, TJ; Burnett, AL; Champion, HC; Jin, L; Lagoda, GA; Liu, T1
Blough, ER; Desai, DH; Rice, KM; Wehner, P; Wright, GL1
Gao, BH; Liu, YQ; Meng, FW; Shi, BK; Xu, ZS; Zhao, ST1
Andersson, KE; Camello, PJ; Gomez, MF; Gomez-Pinilla, PJ; Hedlund, P; Hellstrand, P; Pozo, MJ; Swärd, K1

Reviews

1 review(s) available for y 27632 and Aging

ArticleYear
Inhibition of the tonic contraction in the treatment of erectile dysfunction.
    Expert opinion on therapeutic targets, 2003, Volume: 7, Issue:2

    Topics: Adrenergic Agonists; Adult; Aged; Aging; Amides; Angiotensin II; Calcium Signaling; Cyclic AMP; Endothelin-1; Erectile Dysfunction; Forecasting; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Penis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoactive Intestinal Peptide

2003

Other Studies

19 other study(ies) available for y 27632 and Aging

ArticleYear
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
    BMC anesthesiology, 2021, 09-01, Volume: 21, Issue:1

    Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Isoflurane; Morpholines; Phosphatidylinositol 3-Kinases; Potassium Chloride; Pyridines; Rats, Inbred OLETF; Rats, Wistar; rho-Associated Kinases; Sevoflurane; Vasoconstriction

2021
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway.
    Stem cell reports, 2022, 02-08, Volume: 17, Issue:2

    Topics: Aging; Amides; Animals; Cell Movement; Lateral Ventricles; Mice; Mice, Transgenic; Neural Stem Cells; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Stem Cell Niche; Time-Lapse Imaging

2022
Altered ureteral contractility with ageing: Role of the rho-kinase pathway.
    Mechanisms of ageing and development, 2018, Volume: 171

    Topics: Aging; Amides; Animals; Dose-Response Relationship, Drug; Female; Mice; Muscle Contraction; Phenylephrine; Pyridines; rho-Associated Kinases; Serotonin; Swine; Ureter

2018
Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation.
    Aging, 2019, 05-26, Volume: 11, Issue:10

    Topics: Aging; Amides; Cell Differentiation; Cell Proliferation; Cellular Senescence; Drug Evaluation, Preclinical; Epigenesis, Genetic; Humans; Keratinocytes; Primary Cell Culture; Pyridines; rho-Associated Kinases; Sirolimus; Telomere Homeostasis; TOR Serine-Threonine Kinases

2019
Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats.
    Neurobiology of learning and memory, 2013, Volume: 103

    Topics: Age Factors; Aging; Amides; Animals; Corpus Striatum; Down-Regulation; Enzyme Inhibitors; Maze Learning; Memory, Short-Term; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2013
Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries.
    European journal of applied physiology, 2016, Volume: 116, Issue:5

    Topics: Aging; Amides; Angiotensin II; Animals; Arteries; Endothelium, Vascular; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Physical Conditioning, Animal; Pressure; Pyridines; Rats; Rats, Inbred F344; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents

2016
mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.
    Cell reports, 2016, 11-22, Volume: 17, Issue:9

    Topics: Actin Cytoskeleton; Actins; Aging; Amides; Animals; Anxiety; Behavior, Animal; Brain; Carrier Proteins; Cells, Cultured; Formins; GABAergic Neurons; Mice, Inbred C57BL; Nucleus Accumbens; Optogenetics; Phenotype; Presynaptic Terminals; Pyridines; rho-Associated Kinases; Social Isolation; Ventral Tegmental Area

2016
Cellular mechano-environment regulates the mammary circadian clock.
    Nature communications, 2017, 01-30, Volume: 8

    Topics: Aging; Amides; Animals; Breast; Breast Diseases; Cell Self Renewal; Cellular Microenvironment; Circadian Clocks; Circadian Rhythm; CLOCK Proteins; Epithelial Cells; Epithelium; Extracellular Matrix; Female; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Primary Cell Culture; Pyridines; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Spheroids, Cellular; Tissue Culture Techniques; Vinculin

2017
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling

2010
Aging impairs Ca2+ sensitization pathways in gallbladder smooth muscle.
    Age (Dordrecht, Netherlands), 2012, Volume: 34, Issue:4

    Topics: Aging; Amides; Analysis of Variance; Animals; Bethanechol; Blotting, Western; Calcium Channels; Calcium Signaling; Cholecystokinin; Female; Gallbladder; Guinea Pigs; Isometric Contraction; Melatonin; Models, Animal; Muscle, Smooth; Oxidative Stress; Phosphorylation; Pyridines; Signal Transduction

2012
Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm.
    Coronary artery disease, 2013, Volume: 24, Issue:2

    Topics: Aging; Amides; Animals; Aorta; Ascorbic Acid; Calcium-Binding Proteins; Coronary Vasospasm; Coronary Vessels; Electrocardiography; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Serotonin; Serotonin Receptor Agonists; Sulfhydryl Compounds; Vasoconstriction; Vasodilation

2013
Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-02, Volume: 25, Issue:5

    Topics: Aging; Amides; Animals; Chondroitin Sulfate Proteoglycans; Enzyme Activation; Excitatory Postsynaptic Potentials; Hippocampus; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Phenotype; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Pyridines; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Receptors, Cell Surface; rho-Associated Kinases; Signal Transduction

2005
Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction.
    Cardiovascular research, 2005, Apr-01, Volume: 66, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Aging; Amides; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelium, Vascular; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Kinase C; Pulmonary Artery; Pyridines; rhoA GTP-Binding Protein; Signal Transduction; Swine; Thromboxane A2

2005
Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic Agents; Aging; Amides; Animals; Arteries; Calcium Signaling; Gene Expression Regulation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Obesity; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Zucker; rho-Associated Kinases; rhoA GTP-Binding Protein; Thinness; Vasoconstriction

2006
Rat pulmonary arterial smooth muscle myosin light chain kinase and phosphatase activities decrease with age.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:3

    Topics: Aging; Amides; Animals; Animals, Newborn; Enzyme Inhibitors; Female; Fetus; Gene Expression Regulation, Developmental; Intracellular Signaling Peptides and Proteins; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Protein Subunits; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

2006
Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Aging; Amides; Amino Acid Substitution; Animals; Dependovirus; Erectile Dysfunction; Genetic Therapy; Genetic Vectors; Intracellular Signaling Peptides and Proteins; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth, Vascular; Mutation, Missense; Myosin-Light-Chain Phosphatase; Penis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation

2006
Aging alters mechanical and contractile properties of the Fisher 344/Nnia X Norway/Binia rat aorta.
    Biogerontology, 2007, Volume: 8, Issue:3

    Topics: Aging; Amides; Animals; Aorta; Biomechanical Phenomena; Endothelium, Vascular; Enzyme Inhibitors; Male; Models, Animal; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Heavy Chains; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Potassium; Pyridines; Rats; Rats, Inbred BN; Rats, Inbred F344

2007
Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathways.
    Andrologia, 2007, Volume: 39, Issue:4

    Topics: Aging; Amides; Animals; Erectile Dysfunction; Intracellular Signaling Peptides and Proteins; Male; Models, Molecular; Nitric Oxide Synthase Type I; Penile Erection; Penis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

2007
Melatonin restores impaired contractility in aged guinea pig urinary bladder.
    Journal of pineal research, 2008, Volume: 44, Issue:4

    Topics: Aging; Amides; Animals; Antioxidants; Calcium; Calcium Signaling; Enzyme Inhibitors; Female; Gene Expression Regulation; Guinea Pigs; Indoles; Isometric Contraction; Maleimides; Melatonin; Myosin-Light-Chain Phosphatase; Phosphorylation; Protein Kinase C; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Urinary Bladder; Urinary Bladder Diseases

2008