Page last updated: 2024-11-05

xylazine and Pregnancy

xylazine has been researched along with Pregnancy in 39 studies

Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"In 4 mares suffering from dystocia, general anesthesia was induced with xylazine (1."7.69A case report on the use of guaifenesin-ketamine-xylazine anesthesia for equine dystocia. ( Harrison, IW; Lin, HC; Robbins, RL; Thurmon, JC; Wallace, SS, 1994)
"Isoxsuprine was the only drug that elevated the blood flow volume in the AUM (P ≤ 0."5.40Effect of xylazine, isoxsuprine, and lidocaine on Doppler sonographic uterine and umbilical blood flow measurements in cows during the last month of pregnancy. ( Bleul, U; Waldvogel, D, 2014)
" A minimal effective dosage of 90 mg/kg for ketamine and 10 mg/kg for xylazine provided satisfactory anesthesia in 92% of the subjects, without adverse effects on gestation or the fetuses."5.26Ketamine/xylazine anesthesia in the pregnant rat. ( Stickrod, G, 1979)
"The objective of this in vitro study was to evaluate and compare the effects of xylazine on basal uterine contractility of bovine pregnant uterine strips and that of lidocaine on xylazine-sensitized bovine pregnant uterine strips, at different stages of pregnancy."3.83Lidocaine decreases the xylazine-evoked contractility in pregnant cows. ( D'Onghia, G; Mutinati, M; Piccinno, M; Rizzo, A; Sciorsci, RL, 2016)
" Here we compared the effects of two anaesthetic reagents-a ketamine/xylazine combination, and tribromoethanol (Avertin)-on the rates of implantation and development to term of mouse zygotes transferred into the oviducts of CD-1 foster mothers, and evaluated whether hypothermia caused by anaesthetics after the ET operation could be overcome by postoperative incubation of the foster mothers."3.72Exposure to warmer postoperative temperatures reduces hypothermia caused by anaesthesia and significantly increases the implantation rate of transferred embryos in the mouse. ( Bagis, H; Dinnyes, A; Odaman Mercan, H, 2004)
"Myoelectric activity of the cecum and proximal loop of the ascending colon (PLAC) and the effect of xylazine on motility of this intestinal segment in an experimental cow with large intestinal obstruction are described and compared with the normal motility pattern."3.69Colic motor complex of the cecum and proximal loop of the ascending colon observed in an experimental cow with large intestinal obstruction. ( Ellis, WC; Roussel, AJ; Steiner, A, 1994)
"In 4 mares suffering from dystocia, general anesthesia was induced with xylazine (1."3.69A case report on the use of guaifenesin-ketamine-xylazine anesthesia for equine dystocia. ( Harrison, IW; Lin, HC; Robbins, RL; Thurmon, JC; Wallace, SS, 1994)
" A safe and effective dosage of xylazine-ketamine for Indian fox (Vulpes bengalensis) is reported, based on 37 wild Indian fox immobilizations between April 2006 and May 2007."2.78Use of xylazine hydrochloride-ketamine hydrochloride for immobilization of Indian fox (Vulpes bengalensis) in field situations. ( Belsare, AV; Vanak, AT, 2013)
"Lidocaine was the predominant finding followed by caffeine, and diphenhydramine all of which could result from non-illicit drug exposure, however, there were positives for levamisole, phenacetin, noxiptillin and xylazine none of which are approved in the United States for human therapeutic use."1.72Qualitative LC-Q-TOF Analysis of Umbilical Cord Tissue via Data-Dependent Acquisition as an Indicator of In Utero Exposure to Toxic Adulterating Substances. ( Browne, T; Cervantes, A; Logan, BK; Nelson, BN; Strathmann, FG, 2022)
" bolus injection, the prodrugs' unbound area under the concentration curve in brain was 0."1.43Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs. ( Denny, WA; Gynther, M; Huttunen, KM; Pickering, DS; Spicer, JA, 2016)
"Acepromazine was associated with slight reductions of much shorter duration."1.31Cardiopulmonary effects of xylazine and acepromazine in pregnant cows in late gestation. ( Chapman, PL; Dunlop, CI; Hodgson, DS; Smith, JA, 2002)
"In cows with subclinical ketosis (ketonuria ++ to +++ after Lastradet's test) and hypoglycaemia (blood sugar 29."1.27[Hyperglycemic and therapeutic action of nontranquilizing doses of xylazine in healthy sheep and cows and in cows with subclinical ketosis]. ( Goranov, Kh; Popgeorgieva, M; Zheliazkov, S, 1983)
"Ketamine and Xylazine were given in one injection after being taken in the named sequence and mixed in the syringe."1.26[Clinical use of ketamine-xylazine for anaesthesia in the cat (author's transl)]. ( Arnbjerg, J, 1979)
" A minimal effective dosage of 90 mg/kg for ketamine and 10 mg/kg for xylazine provided satisfactory anesthesia in 92% of the subjects, without adverse effects on gestation or the fetuses."1.26Ketamine/xylazine anesthesia in the pregnant rat. ( Stickrod, G, 1979)
" Maximum blood glucose concentrations were reached approximately 40 minutes after dosing and did not start to fall until 185 minutes."1.26The effect of xylazine upon hepatic glucose production and blood flow rate in the lactating dairy cow. ( Symonds, HW, 1976)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199015 (38.46)18.7374
1990's11 (28.21)18.2507
2000's5 (12.82)29.6817
2010's6 (15.38)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Nelson, BN1
Strathmann, FG1
Browne, T1
Cervantes, A1
Logan, BK1
Aghamiri, SM1
Samimi, AS1
Hajian, M1
Samimi, AM1
Oroumieh, A1
Tsukamoto, A1
Konishi, Y1
Kawakami, T1
Koibuchi, C1
Sato, R1
Kanai, E1
Inomata, T1
Sciorsci, RL2
Piccinno, M2
Rizzo, A2
Belsare, AV1
Vanak, AT1
Waldvogel, D1
Bleul, U1
Gynther, M1
Pickering, DS1
Spicer, JA1
Denny, WA1
Huttunen, KM1
Mutinati, M1
D'Onghia, G1
Hodgson, DS1
Dunlop, CI1
Chapman, PL1
Smith, JA1
Nishigai, M1
Smith, JC1
Corbin, TJ1
McCabe, JG1
Bolon, B1
Bagis, H1
Odaman Mercan, H1
Dinnyes, A1
Wright, M1
Bartholomew, JL1
Tezak, TM1
Montrey, RD1
Citino, SB1
Bush, M1
Phillips, LG1
Goranov, Kh1
Zheliazkov, S1
Popgeorgieva, M1
Jansen, CA1
Lowe, KC1
Nathanielsz, PW1
Hubbell, JA1
Muir, WW1
Sams, RA1
Lincoln, DW1
Hentzen, K1
Hin, T1
van der Schoot, P1
Clarke, G1
Summerlee, AJ1
Arnemo, JM1
Søli, NE1
Steiner, A1
Roussel, AJ1
Ellis, WC1
Lin, HC1
Wallace, SS1
Robbins, RL1
Harrison, IW1
Thurmon, JC1
Sakamoto, H1
Misumi, K1
Nakama, M1
Aoki, Y1
Card, CE1
Manning, ST1
Bowman, P1
Leibel, T1
Scott, PR1
Gessert, ME1
Zeller, W1
Meier, G1
Bürki, K1
Panoussis, B1
Furukawa, S1
MacLennan, MJ1
Keller, BB1
Hughan, SC1
Loose, JM1
Caddy, DJ1
Canny, BJ1
Tilbrook, AJ1
Young, IR1
Holmes, AM1
Clark, WT1
Arnbjerg, J1
Stickrod, G1
Symonds, HW1
Navarro, JA1
Friedman, JR1
Gibbs, EP1
McDiarmid, A1
Rowe, JJ1
Daunt, DA1
Steffey, EP1
Pascoe, JR1
Willits, N1
Daels, PF1
Travaini, A1
Ferreras, P1
Delibes, M1
Aldama, JJ1
Van Metre, DC1
Woods, R1
Hindell, M1
Slip, DJ1
DelGiudice, GD1
Mech, LD1
Paul, WJ1
Karns, PD1

Reviews

2 reviews available for xylazine and Pregnancy

ArticleYear
Pharmacologic effects of ketamine and its use in veterinary medicine.
    Journal of the American Veterinary Medical Association, 1982, Jun-15, Volume: 180, Issue:12

    Topics: Amphetamine; Anesthesia; Animals; Antipsychotic Agents; Brain; Cardiovascular System; Cats; Cattle;

1982
Xylazine for sedation of horses.
    New Zealand veterinary journal, 1977, Volume: 25, Issue:6

    Topics: Analgesia; Animals; Blood Pressure; Cardiac Output; Cats; Dogs; Female; Heart Conduction System; Hea

1977

Trials

3 trials available for xylazine and Pregnancy

ArticleYear
Effect of xylazine, detomidine, medetomidine and dexmedetomidine during laparoscopic SCNT embryo transfer on pregnancy rate and some physiological variables in goats.
    BMC veterinary research, 2022, Mar-15, Volume: 18, Issue:1

    Topics: Animals; Dexmedetomidine; Embryo Transfer; Female; Goats; Imidazoles; Laparoscopy; Medetomidine; Pre

2022
Use of xylazine hydrochloride-ketamine hydrochloride for immobilization of Indian fox (Vulpes bengalensis) in field situations.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2013, Volume: 44, Issue:3

    Topics: Anesthetics, Dissociative; Animals; Drug Combinations; Female; Foxes; Hypnotics and Sedatives; Ketam

2013
Combined xylazine and ketamine as an analgesic regimen in sheep.
    Australian veterinary journal, 2001, Volume: 79, Issue:3

    Topics: Analgesics; Animals; Drug Therapy, Combination; Female; Hydrocortisone; Ketamine; Pain Measurement;

2001

Other Studies

34 other studies available for xylazine and Pregnancy

ArticleYear
Qualitative LC-Q-TOF Analysis of Umbilical Cord Tissue via Data-Dependent Acquisition as an Indicator of In Utero Exposure to Toxic Adulterating Substances.
    Journal of analytical toxicology, 2022, Jul-14, Volume: 46, Issue:6

    Topics: Analgesics, Opioid; Caffeine; Cocaine; Diphenhydramine; Drug Contamination; Female; Humans; Levamiso

2022
Pharmacological properties of various anesthetic protocols in 10-day-old neonatal rats.
    Experimental animals, 2017, Oct-30, Volume: 66, Issue:4

    Topics: Anesthesia; Anesthetics, Combined; Animals; Animals, Newborn; Butorphanol; Dose-Response Relationshi

2017
Scopolamine butylbromide decreases the xylazine-mediated contractility in bovine pregnant uteri.
    Theriogenology, 2018, Mar-01, Volume: 108

    Topics: Animals; Butylscopolammonium Bromide; Cattle; Female; In Vitro Techniques; Muscarinic Antagonists; M

2018
Effect of xylazine, isoxsuprine, and lidocaine on Doppler sonographic uterine and umbilical blood flow measurements in cows during the last month of pregnancy.
    Theriogenology, 2014, Apr-15, Volume: 81, Issue:7

    Topics: Adrenergic beta-Agonists; Anesthetics, Local; Animals; Blood Flow Velocity; Cattle; Female; Hypnotic

2014
Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs.
    Molecular pharmaceutics, 2016, 07-05, Volume: 13, Issue:7

    Topics: Animals; Astrocytes; Biological Transport; Blood-Brain Barrier; Brain; Cells, Cultured; Chromatograp

2016
Lidocaine decreases the xylazine-evoked contractility in pregnant cows.
    Research in veterinary science, 2016, Volume: 107

    Topics: Anesthetics, Local; Animals; Carbachol; Cattle; Drug Therapy, Combination; Female; Lidocaine; Pregna

2016
Cardiopulmonary effects of xylazine and acepromazine in pregnant cows in late gestation.
    American journal of veterinary research, 2002, Volume: 63, Issue:12

    Topics: Acepromazine; Adrenergic alpha-Agonists; Animals; Blood Pressure; Cattle; Dopamine Antagonists; Fema

2002
Japanese Society for Animal Reproduction: award for outstanding research 2002. The development and prevalence of the transfer technique for frozen-thawed embryos of Japanese black beef cattle in Tochigi Prefecture.
    The Journal of reproduction and development, 2003, Volume: 49, Issue:1

    Topics: Animals; Cattle; Cryopreservation; Embryo Transfer; Estradiol; Female; Freezing; Pregnancy; Pregnanc

2003
Isoflurane with morphine is a suitable anaesthetic regimen for embryo transfer in the production of transgenic rats.
    Laboratory animals, 2004, Volume: 38, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Animals, Genetically Modified; Embryo Implantation; Embryo Transfe

2004
Exposure to warmer postoperative temperatures reduces hypothermia caused by anaesthesia and significantly increases the implantation rate of transferred embryos in the mouse.
    Laboratory animals, 2004, Volume: 38, Issue:1

    Topics: Anesthetics; Animals; Embryo Implantation; Embryo Transfer; Embryonic and Fetal Development; Ethanol

2004
Effects of anesthetics and foster mother experience on survival rate of cesarean derived, foster suckled rat pups.
    Laboratory animal science, 1984, Volume: 34, Issue:6

    Topics: Anesthesia; Animals; Animals, Suckling; Carbon Dioxide; Cesarean Section; Euthanasia; Female; Ketami

1984
Dystocia and fatal hyperthermic episode in a giraffe.
    Journal of the American Veterinary Medical Association, 1984, Dec-01, Volume: 185, Issue:11

    Topics: Anesthesia; Animals; Animals, Zoo; Artiodactyla; Atropine; Dystocia; Etorphine; Female; Fetal Death;

1984
[Hyperglycemic and therapeutic action of nontranquilizing doses of xylazine in healthy sheep and cows and in cows with subclinical ketosis].
    Veterinarno-meditsinski nauki, 1983, Volume: 20, Issue:3-4

    Topics: Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Dose-Response Relationship, Drug; Drug Ev

1983
The effects of xylazine on uterine activity, fetal and maternal oxygenation, cardiovascular function, and fetal breathing.
    American journal of obstetrics and gynecology, 1984, Feb-15, Volume: 148, Issue:4

    Topics: Animals; Diaphragm; Electromyography; Female; Fetal Blood; Fetal Heart; Fetus; Heart Rate; Oxygen; P

1984
Guaifenesin: cardiopulmonary effects and plasma concentrations in horses.
    American journal of veterinary research, 1980, Volume: 41, Issue:11

    Topics: Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Cardiovascular System; Female; Fetal Bloo

1980
Sleep: a prerequisite for reflex milk ejection in the rat.
    Experimental brain research, 1980, Volume: 38, Issue:2

    Topics: Animals; Animals, Suckling; Arousal; Cortical Synchronization; Electroencephalography; Evoked Potent

1980
Chemical capture of free-ranging cattle: immobilization with xylazine or medetomidine, and reversal with atipamezole.
    Veterinary research communications, 1993, Volume: 17, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Drug Evaluation; Female; H

1993
Colic motor complex of the cecum and proximal loop of the ascending colon observed in an experimental cow with large intestinal obstruction.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1994, Volume: 41, Issue:1

    Topics: Animals; Cattle; Cattle Diseases; Cecum; Colon; Electromyography; Female; Intestinal Obstruction; My

1994
A case report on the use of guaifenesin-ketamine-xylazine anesthesia for equine dystocia.
    The Cornell veterinarian, 1994, Volume: 84, Issue:1

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Animals; Dystocia; Extraction, Obstetrical; Female; Gu

1994
The effects of xylazine on intrauterine pressure, uterine blood flow, maternal and fetal cardiovascular and pulmonary function in pregnant goats.
    The Journal of veterinary medical science, 1996, Volume: 58, Issue:3

    Topics: Animals; Blood Pressure; Carbon Dioxide; Female; Goats; Heart; Heart Rate; Heart Rate, Fetal; Hydrog

1996
Pregnancies from imipramine and xylazine-induced ex copula ejaculation in a disabled stallion.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1997, Volume: 38, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Breeding; Disabled Persons; Ejaculation; Female; Horses;

1997
Evaluation of extradural xylazine injection for caesarean operation in ovine dystocia cases.
    Veterinary journal (London, England : 1997), 1997, Volume: 154, Issue:1

    Topics: Analgesia, Obstetrical; Anesthetics; Animals; Cesarean Section; Dose-Response Relationship, Drug; Dy

1997
Adverse effects of tribromoethanol as used in the production of transgenic mice.
    Laboratory animals, 1998, Volume: 32, Issue:4

    Topics: Anesthetics; Animals; Embryo Transfer; Ethanol; Female; Ketamine; Liver; Mice; Mice, Transgenic; Mus

1998
Hemodynamic response to anesthesia in pregnant and nonpregnant ICR mice.
    Laboratory animal science, 1998, Volume: 48, Issue:4

    Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Hemodynamics;

1998
[Clinical use of ketamine-xylazine for anaesthesia in the cat (author's transl)].
    Nordisk veterinaermedicin, 1979, Volume: 31, Issue:4

    Topics: Anesthesia, General; Animals; Cats; Drug Combinations; Drug Evaluation; Female; Injections, Intramus

1979
Ketamine/xylazine anesthesia in the pregnant rat.
    Journal of the American Veterinary Medical Association, 1979, Nov-01, Volume: 175, Issue:9

    Topics: Anesthesia; Animals; Female; Ketamine; Male; Pregnancy; Rats; Thiazines; Xylazine

1979
The effect of xylazine upon hepatic glucose production and blood flow rate in the lactating dairy cow.
    The Veterinary record, 1976, Sep-18, Volume: 99, Issue:12

    Topics: Animals; Blood Flow Velocity; Blood Glucose; Cattle; Female; Glucose; Lactation; Liver; Liver Circul

1976
A clinical evaluation of xylazine and ketamine HCL for cesarean section in the dog.
    Veterinary medicine, small animal clinician : VM, SAC, 1975, Volume: 70, Issue:9

    Topics: Anesthesia, Obstetrical; Animals; Cesarean Section; Dogs; Female; Ketamine; Pregnancy; Thiazines; Xy

1975
Management of deer for experimental studies with foor-and-mouth disease virus.
    The Veterinary record, 1975, Jun-07, Volume: 96, Issue:23

    Topics: Abortion, Veterinary; Acepromazine; Animal Feed; Animal Nutritional Physiological Phenomena; Animals

1975
Actions of isoflurane and halothane in pregnant mares.
    Journal of the American Veterinary Medical Association, 1992, Nov-01, Volume: 201, Issue:9

    Topics: Anesthesia, Inhalation; Animals; Bilirubin; Blood Pressure; Calcium; Carbon Dioxide; Creatine Kinase

1992
Xylazine hydrochloride-ketamine hydrochloride immobilization of free-living red foxes (Vulpes vulpes) in Spain.
    Journal of wildlife diseases, 1992, Volume: 28, Issue:3

    Topics: Animals; Animals, Wild; Female; Foxes; Immobilization; Ketamine; Male; Pregnancy; Spain; Xylazine

1992
A case report of the treatment of an overdose of xylazine in a cow.
    The Cornell veterinarian, 1992, Volume: 82, Issue:3

    Topics: Animals; Atropine; Bradycardia; Cattle; Cattle Diseases; Drug Overdose; Female; Fluid Therapy; Heart

1992
Effects of physiological state on duration of sedation in southern elephant seals.
    Journal of wildlife diseases, 1989, Volume: 25, Issue:4

    Topics: Analysis of Variance; Anesthesia; Animals; Body Weight; Caniformia; Female; Ketamine; Lactation; Pos

1989
Effects on fawn survival of multiple immobilizations of captive pregnant white-tailed deer.
    Journal of wildlife diseases, 1986, Volume: 22, Issue:2

    Topics: Animals; Animals, Newborn; Deer; Female; Fertility; Immobilization; Ketamine; Male; Pregnancy; Pregn

1986