xylazine has been researched along with Muscle Contraction in 35 studies
Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") caused a 20-30 fold rightward displacement of the dose-response curve to xylazine, but did not affect responses to B-HT933." | 1.28 | Alpha 2-adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes. ( Akers, I; Coates, J; Drew, GM; Sullivan, AT, 1991) |
| " These results show that the adaptative changes of alpha-adrenoceptors in the rat anococcygeus muscle following long-term administration may depend on the efficiency to inhibit the neuronal uptake and the ability to antagonize alpha 1-adrenoceptors." | 1.28 | Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle. ( Badia, A; Sallés, J; Vila, E, 1990) |
| "Nisoxetine was also less potent than desipramine in inhibiting responses to histamine, carbachol and bradykinin on the guinea-pig isolated ileum." | 1.27 | Some pharmacological actions of nisoxetine, a bicyclic inhibitor of noradrenaline uptake. ( Foley, AJ; Leedham, JA; Pennefather, JN, 1985) |
| " Xylazine at a dosage of 1." | 1.27 | Effects of xylazine on cecal mechanical activity and cecal blood flow in healthy horses. ( Becht, JL; Clark, ES; Moore, JN; Thompson, SA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (51.43) | 18.7374 |
| 1990's | 12 (34.29) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Menozzi, A | 1 |
| Pozzoli, C | 1 |
| Poli, E | 1 |
| Colla, C | 1 |
| Placenza, G | 1 |
| Bertini, S | 1 |
| Wooldridge, AA | 1 |
| Eades, SC | 1 |
| Hosgood, GL | 1 |
| Moore, RM | 1 |
| Vandeputte, C | 1 |
| Aiden McCormick, P | 1 |
| Docherty, JR | 9 |
| Toutain, PL | 1 |
| Zingoni, MR | 1 |
| Ruckebusch, Y | 2 |
| MacDonald, A | 1 |
| McGrath, JC | 2 |
| Lues, I | 1 |
| Schümann, HJ | 1 |
| Moore, PK | 1 |
| Griffiths, RJ | 1 |
| O'Malley, K | 2 |
| Vizi, ES | 4 |
| Ludvig, N | 1 |
| Rónai, AZ | 1 |
| Folly, G | 1 |
| Papazoglou, L | 1 |
| Raptopoulos, D | 1 |
| Kounenis, G | 1 |
| Shin, DH | 1 |
| Yu, H | 1 |
| Hsu, WH | 1 |
| O'Rourke, M | 1 |
| Kearns, S | 1 |
| Colucci, R | 1 |
| Blandizzi, C | 1 |
| Carignani, D | 1 |
| Lazzeri, G | 1 |
| Natale, G | 1 |
| Crema, F | 1 |
| Del Tacca, M | 1 |
| Nakamura, K | 1 |
| Hara, S | 1 |
| Tomizawa, N | 1 |
| Sasaki, N | 1 |
| Mizuno, Y | 1 |
| Yoshihara, T | 1 |
| Haynes, JM | 1 |
| Selbie, LA | 1 |
| Hill, SJ | 1 |
| Lapointe, BM | 1 |
| Côté, CH | 1 |
| Menzies, JR | 1 |
| Corbett, AD | 1 |
| Rajamani, K | 1 |
| Leong, S | 1 |
| Lavelle, A | 1 |
| Knoll, J | 1 |
| Harsing, LG | 1 |
| Sperlágh, B | 1 |
| Akers, I | 1 |
| Coates, J | 1 |
| Drew, GM | 1 |
| Sullivan, AT | 1 |
| Vila, E | 1 |
| Sallés, J | 1 |
| Badia, A | 1 |
| Warnock, P | 1 |
| Hyland, L | 1 |
| Allal, C | 1 |
| Khoyi, MA | 1 |
| Westfall, DP | 1 |
| Gerthoffer, WT | 1 |
| Virtanen, R | 1 |
| Nyman, L | 1 |
| Leedham, JA | 1 |
| Foley, AJ | 1 |
| Pennefather, JN | 1 |
| Clark, ES | 1 |
| Thompson, SA | 1 |
| Becht, JL | 1 |
| Moore, JN | 1 |
1 review available for xylazine and Muscle Contraction
| Article | Year |
|---|---|
Ageing and alpha-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta; Blood Platelets; Hum | 1985 |
34 other studies available for xylazine and Muscle Contraction
| Article | Year |
|---|---|
Effects of selective α
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Bronchi; Carbachol; Electric St | 2018 |
In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus.
Topics: Acepromazine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics, Opioid; Animals; Area | 2002 |
Responsiveness to noradrenaline in aorta from wild-type, nitric oxide synthase-2, nitric oxide synthase-3 and alpha2A/D-adrenoceptor knockout mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Endothelium, Vasc | 2003 |
Assessment of alpha-2 adrenergic antagonists on the central nervous system using reticular contraction in sheep as a model.
Topics: Adrenergic alpha-Antagonists; Animals; Central Nervous System; Electromyography; Female; Manometry; | 1982 |
An investigation of presynaptic alpha-adrenoceptor subtypes in the pithed rat heart and in the rat isolated vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Electric Stimulation; Ethanolamines; Heart Rate; | 1984 |
Post-natal development of functional neurotransmission in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; | 1984 |
Effect of removing the endothelial cells on the reactivity of rat aortic segments to different alpha-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Azepines; Clonidine; Endothelium; Imidazoles; I | 1984 |
Pre-synaptic and post-synaptic effects of xylazine and naphazoline on the bisected rat vas deferens.
Topics: Animals; Electric Stimulation; Epididymis; Imidazoles; In Vitro Techniques; Male; Muscle Contraction | 1982 |
An examination of age-related changes in pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens.
Topics: Aging; Animals; Ethanolamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; | 1983 |
Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin.
Topics: Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Pr | 1983 |
The effect of xylazine on the isolated sheep trachea.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Dose-Response Relationship, Drug; Drug Interactions | 1995 |
A paradoxical stimulatory effect of berberine on guinea-pig ileum contractility: possible involvement of acetylcholine release from the postganglionic parasympathetic nerve and cholinesterase inhibition.
Topics: Acetylcholine; Animals; Berberine; Cholinesterases; Electric Stimulation; Guinea Pigs; Ileum; In Vit | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; | 1995 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1996 |
The effects of medetomidine and xylazine on gastrointestinal motility and gastrin release in the dog.
Topics: Adrenergic alpha-Agonists; Animals; Dogs; Duodenum; Female; Gastrins; Gastrointestinal Motility; Ile | 1997 |
The application of electrocecography for evaluation of cecum motility in horses.
Topics: Adrenergic alpha-Agonists; Animals; Cecum; Electromyography; Gastrointestinal Motility; Horses; Male | 1998 |
Gi-Protein alpha-subunit mRNA antisense oligonucleotide inhibition of Gi-coupled receptor contractile activity in the epididymis of the guinea-pig.
Topics: Adenosine; Animals; Blotting, Western; Cell Membrane; Epididymis; GTP-Binding Protein alpha Subunits | 1999 |
Anesthetics can alter subsequent in vitro assessment of contractility in slow and fast skeletal muscles of rat.
Topics: Anesthetics; Animals; Female; Ketamine; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fiber | 1999 |
Nociceptin inhibits tonic nitric oxide release in the mouse isolated proximal colon.
Topics: Animals; Carbachol; Colon; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; Mice; Mice, In | 2000 |
Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Desipramine; Do | 2001 |
The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine.
Topics: Acetylcholine; Adenine Nucleotides; Adenosine; Animals; Cerebral Cortex; Cholecystokinin; Electric S | 1976 |
Different sites of action for alpha 2-adrenoceptor antagonists in the modulation of noradrenaline release and contraction response in the vas deferens of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Berberine; Chromatography, High Pressure Liquid; Dioxanes; Id | 1992 |
Is the neuronal ATP release from guinea-pig vas deferens subject to alpha 2-adrenoceptor-mediated modulation?
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Berberine; | 1992 |
Alpha 2-adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Azepines; Benzaze | 1991 |
Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Antidepressive Agents; Cocaine; Desipramine; Electric Stimulation; Male; Mianserin; Muscle | 1990 |
Further examination of the inhibitory actions of alpha 1-adrenoceptor agonists in rat vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Pertussis toxin and pre-junctional alpha 2-adrenoreceptors in rat heart and vas deferens.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Blood Pressure; Heart; Heart Rate; In | 1988 |
alpha-Adrenoceptor agonists and the Ca2+-dependence of smooth muscle contraction: evidence for subtypes of receptors or for agonist-dependent differences in the agonist-receptor interaction?
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Clonidine; Ethanolamines; Male; Methoxamine; Muscle Con | 1985 |
Depression of reticulo-ruminal motor functions through the stimulation of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Cattle; Clonidine; Female; Imidazoles; Muscle Contraction; Retic | 1987 |
Effects of potassium and norepinephrine on calcium influx in guinea-pig vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Calcium Radioisotopes; Guinea Pigs; In Vitro Techniques | 1987 |
The effects of ageing on vascular alpha-adrenoceptors in pithed rat and rat aorta.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Aorta; Blood Pressure; Decerebrate State; Ethanolamines; | 1988 |
Evaluation of the alpha 1- and alpha 2-adrenoceptor effects of detomidine, a novel veterinary sedative analgesic.
Topics: Analgesics; Animals; Clonidine; Electric Stimulation; Female; Hypnotics and Sedatives; Imidazoles; I | 1985 |
Some pharmacological actions of nisoxetine, a bicyclic inhibitor of noradrenaline uptake.
Topics: Animals; Bradykinin; Carbachol; Desipramine; Fluoxetine; Guinea Pigs; Histamine; In Vitro Techniques | 1985 |
Effects of xylazine on cecal mechanical activity and cecal blood flow in healthy horses.
Topics: Animals; Blood Pressure; Carotid Arteries; Cecum; Female; Gastrointestinal Motility; Heart Rate; Hor | 1988 |