Page last updated: 2024-11-05

xylazine and Hypothermia

xylazine has been researched along with Hypothermia in 11 studies

Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths."8.31Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023)
"These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths."4.31Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023)
" Here we compared the effects of two anaesthetic reagents-a ketamine/xylazine combination, and tribromoethanol (Avertin)-on the rates of implantation and development to term of mouse zygotes transferred into the oviducts of CD-1 foster mothers, and evaluated whether hypothermia caused by anaesthetics after the ET operation could be overcome by postoperative incubation of the foster mothers."3.72Exposure to warmer postoperative temperatures reduces hypothermia caused by anaesthesia and significantly increases the implantation rate of transferred embryos in the mouse. ( Bagis, H; Dinnyes, A; Odaman Mercan, H, 2004)
"In studies of experimentally induced retrograde amnesia (RA), as the interval between training and the amnestic treatment is lengthened, amnesia decreases (4)."1.30Ketaset-Rompun extends the temporal gradient for hypothermia-induced retrograde amnesia. ( Metzger, MM; Riccio, DC, 1999)
"Halothane was most effective in producing anaesthesia in Monodelphis domestica."1.27An evaluation of three anaesthetic regimes in the gray short-tailed opossum (Monodelphis domestica). ( Bowman, TA; Drozdowicz, CK; Keller, LS; Lang, CM; Rice, L, 1988)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's2 (18.18)18.2507
2000's3 (27.27)29.6817
2010's2 (18.18)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Bailey, KT1
Jantre, SR1
Lawrence, FR1
Hankenson, FC1
Del Valle, JM1
Choi, S1
Irwin, MR1
Kiyatkin, EA1
Tarahovsky, YS1
Khrenov, MO1
Kovtun, AL1
Zakharova, NM1
Tsukamoto, A2
Konishi, Y1
Kawakami, T1
Koibuchi, C1
Sato, R1
Kanai, E1
Inomata, T2
Niino, N1
Sakamoto, M1
Ohtani, R1
Bagis, H1
Odaman Mercan, H1
Dinnyes, A1
Johnston, NA1
Bosgraaf, C1
Cox, L1
Reichensperger, J1
Verhulst, S1
Patten, C1
Toth, LA1
Lefkov, SH1
Müssig, D1
Charlet de Sauvage, R1
da Costa, DL1
Erre, JP1
Aran, JM1
Metzger, MM1
Riccio, DC1
Keller, LS1
Drozdowicz, CK1
Rice, L1
Bowman, TA1
Lang, CM1

Trials

1 trial available for xylazine and Hypothermia

ArticleYear
Strategies for refinement of abdominal device implantation in mice: strain, carboxymethylcellulose, thermal support, and atipamezole.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2007, Volume: 46, Issue:2

    Topics: Abdomen; Anesthetics; Anesthetics, Combined; Animals; Body Temperature; Carboxymethylcellulose Sodiu

2007

Other Studies

10 other studies available for xylazine and Hypothermia

ArticleYear
Evaluation of Active Warming and Surgical Draping for Perioperative Thermal Support in Laboratory Mice.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2022, 09-01, Volume: 61, Issue:5

    Topics: Animals; Body Temperature; Hypothermia; Ketamine; Mice; Plastics; Water; Xylazine

2022
Xylazine effects on opioid-induced brain hypoxia.
    Psychopharmacology, 2023, Volume: 240, Issue:7

    Topics: Analgesics, Opioid; Animals; Drug Overdose; Fentanyl; Heroin; Humans; Hypothermia; Hypoxia; Hypoxia,

2023
Comparison of natural and pharmacological hypothermia in animals: Determination of activation energy of metabolism.
    Journal of thermal biology, 2020, Volume: 92

    Topics: Animals; Body Temperature; Body Temperature Regulation; Energy Metabolism; Hibernation; Hypnotics an

2020
Pharmacological properties of various anesthetic protocols in 10-day-old neonatal rats.
    Experimental animals, 2017, Oct-30, Volume: 66, Issue:4

    Topics: Anesthesia; Anesthetics, Combined; Animals; Animals, Newborn; Butorphanol; Dose-Response Relationshi

2017
The validity of anesthetic protocols for the surgical procedure of castration in rats.
    Experimental animals, 2018, Jul-30, Volume: 67, Issue:3

    Topics: Administration, Inhalation; Anesthesia; Anesthetics; Animal Experimentation; Animals; Bradycardia; B

2018
Exposure to warmer postoperative temperatures reduces hypothermia caused by anaesthesia and significantly increases the implantation rate of transferred embryos in the mouse.
    Laboratory animals, 2004, Volume: 38, Issue:1

    Topics: Anesthetics; Animals; Embryo Implantation; Embryo Transfer; Embryonic and Fetal Development; Ethanol

2004
Tiletamine-zolazepam and xylazine is a potent cardiodepressive combination: a case report.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2007, Volume: 46, Issue:6

    Topics: Animals; Animals, Laboratory; Anti-Arrhythmia Agents; Body Temperature; Disease Models, Animal; Drug

2007
Changes in CM and CAP with sedation and temperature in the guinea pig: facts and interpretation.
    Hearing research, 1996, Dec-01, Volume: 102, Issue:1-2

    Topics: Acoustic Stimulation; Action Potentials; Animals; Audiometry; Body Temperature Regulation; Cochlear

1996
Ketaset-Rompun extends the temporal gradient for hypothermia-induced retrograde amnesia.
    Physiology & behavior, 1999, Volume: 66, Issue:5

    Topics: Adrenergic alpha-Agonists; Amnesia, Retrograde; Analysis of Variance; Anesthetics, Dissociative; Ani

1999
An evaluation of three anaesthetic regimes in the gray short-tailed opossum (Monodelphis domestica).
    Laboratory animals, 1988, Volume: 22, Issue:3

    Topics: Anesthesia; Animals; Halothane; Hypothermia; Ketamine; Opossums; Pentobarbital; Xylazine

1988