Page last updated: 2024-11-05

xylazine and Hyperglycemia

xylazine has been researched along with Hyperglycemia in 14 studies

Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
" In fed Sprague-Dawley rats, ketamine (100 mg/kg)/xylazine (10 mg/kg) (KX) produced acute hyperglycemia (blood glucose 178."7.73Acute hyperglycemia induced by ketamine/xylazine anesthesia in rats: mechanisms and implications for preclinical models. ( Engle, SK; Grondin, JM; Jakubowski, JA; Saha, JK; Xia, J, 2005)
" The greatest urine volume, similar to changes in peak glucose concentration, always occurred during the first hour after dosing with xylazine and averaged 1."5.27Xylazine causes transient dose-related hyperglycemia and increased urine volumes in mares. ( Howland, D; Steffey, EP; Thurmon, JC; Woliner, M; Zinkl, JG, 1984)
"Treatment with yohimbine prevented xylazine-induced hypoinsulinemia and hyperglycemia."5.27Effect of yohimbine on xylazine-induced hypoinsulinemia and hyperglycemia in mares. ( Benson, GJ; Greene, SA; Thurmon, JC; Tranquilli, WJ, 1987)
" Ketamine/xylazine mixture induces hyperglycemia, although the mechanism involved is unknown."3.79Anesthetic-induced transient hyperglycemia and insulin resistance do not depend on the sympathoadrenal axis. ( Barella, LF; Cezar De Freitas Mathias, P; Chaves Souto Branco, R; De Oliveira, JC; Grassiolli, S; Gravena, C; Ludemann Camargo, R; Torrezan, R, 2013)
" In fed Sprague-Dawley rats, ketamine (100 mg/kg)/xylazine (10 mg/kg) (KX) produced acute hyperglycemia (blood glucose 178."3.73Acute hyperglycemia induced by ketamine/xylazine anesthesia in rats: mechanisms and implications for preclinical models. ( Engle, SK; Grondin, JM; Jakubowski, JA; Saha, JK; Xia, J, 2005)
"Xylazine alone has proven harmful to humans and even more when it is combined with drugs of abuse."2.50Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature. ( Chavez-Arias, C; Díaz-Alcalá, JE; Martínez, MA; Ruiz-Colón, K, 2014)
"The presence of cerebral hemorrhage after reperfusion was checked macroscopically and infarct volume with 2,3,5-triphenyltetrazolium staining."1.30Hyperglycemia and the vascular effects of cerebral ischemia. ( Betz, AL; Kawai, N; Keep, RF, 1997)
"In cows with subclinical ketosis (ketonuria ++ to +++ after Lastradet's test) and hypoglycaemia (blood sugar 29."1.27[Hyperglycemic and therapeutic action of nontranquilizing doses of xylazine in healthy sheep and cows and in cows with subclinical ketosis]. ( Goranov, Kh; Popgeorgieva, M; Zheliazkov, S, 1983)
" The greatest urine volume, similar to changes in peak glucose concentration, always occurred during the first hour after dosing with xylazine and averaged 1."1.27Xylazine causes transient dose-related hyperglycemia and increased urine volumes in mares. ( Howland, D; Steffey, EP; Thurmon, JC; Woliner, M; Zinkl, JG, 1984)
"Treatment with yohimbine prevented xylazine-induced hypoinsulinemia and hyperglycemia."1.27Effect of yohimbine on xylazine-induced hypoinsulinemia and hyperglycemia in mares. ( Benson, GJ; Greene, SA; Thurmon, JC; Tranquilli, WJ, 1987)
"Xylazine was administered intravenously (0."1.26Effect of adrenergic drugs on glucose and plasma glucagon and insulin responses to xylazine in sheep. ( Brockman, RP; Muggaberg, J, 1982)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's2 (14.29)18.2507
2000's2 (14.29)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Oliveira, JC1
Ludemann Camargo, R1
Barella, LF1
Chaves Souto Branco, R1
Gravena, C1
Grassiolli, S1
Torrezan, R1
Cezar De Freitas Mathias, P1
Ruiz-Colón, K1
Chavez-Arias, C1
Díaz-Alcalá, JE1
Martínez, MA1
Yaralioglu-Gurgoze, S1
Sindak, N1
Sahin, T1
Cen, O1
Saha, JK1
Xia, J1
Grondin, JM1
Engle, SK1
Jakubowski, JA1
Hsu, WH1
Hummel, SK1
Tranquilli, WJ2
Thurmon, JC3
Neff-Davis, CA1
Davis, LE1
Benson, GJ2
Hoffman, W1
Lock, TF1
Goranov, Kh1
Zheliazkov, S1
Popgeorgieva, M1
Steffey, EP1
Zinkl, JG1
Woliner, M1
Howland, D1
Muggaberg, J1
Brockman, RP1
Kawai, N1
Keep, RF1
Betz, AL1
Eichner, RD1
Prior, RL1
Kvasnicka, WG1
Raptopoulos, D1
Brikas, P1
Tsiamitas, C1
Ayiannidis, A1
Greene, SA1

Reviews

1 review available for xylazine and Hyperglycemia

ArticleYear
Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature.
    Forensic science international, 2014, Volume: 240

    Topics: Bradycardia; Chromatography; Drug Contamination; Forensic Toxicology; Humans; Hyperglycemia; Hypnoti

2014

Other Studies

13 other studies available for xylazine and Hyperglycemia

ArticleYear
Anesthetic-induced transient hyperglycemia and insulin resistance do not depend on the sympathoadrenal axis.
    Minerva endocrinologica, 2013, Volume: 38, Issue:4

    Topics: Adrenal Medulla; Adult; Anesthetics; Animals; Disease Models, Animal; Drug Combinations; Glucose Int

2013
Levels of glutathione peroxidase, lipoperoxidase and some biochemical and haematological parameters in gazelles anaesthetised with a tiletamin-zolazepam-xylazine combination.
    Veterinary journal (London, England : 1997), 2005, Volume: 169, Issue:1

    Topics: Anesthetics, Combined; Anesthetics, Dissociative; Animals; Antelopes; Glutathione Peroxidase; Hyperg

2005
Acute hyperglycemia induced by ketamine/xylazine anesthesia in rats: mechanisms and implications for preclinical models.
    Experimental biology and medicine (Maywood, N.J.), 2005, Volume: 230, Issue:10

    Topics: Anesthetics; Animals; Blood Glucose; Drug Combinations; Eating; Fasting; Hyperglycemia; Injections,

2005
Xylazine-induced hyperglycemia in cattle: a possible involvement of alpha 2-adrenergic receptors regulating insulin release.
    Endocrinology, 1981, Volume: 109, Issue:3

    Topics: Animals; Blood Glucose; Cattle; Female; Hyperglycemia; Insulin; Insulin Secretion; Phentolamine; Pra

1981
Hyperglycemia and hypoinsulinemia during xylazine-ketamine anesthesia in Thoroughbred horses.
    American journal of veterinary research, 1984, Volume: 45, Issue:1

    Topics: Anesthesia; Animals; Blood Glucose; Catecholamines; Female; Horse Diseases; Horses; Hyperglycemia; I

1984
[Hyperglycemic and therapeutic action of nontranquilizing doses of xylazine in healthy sheep and cows and in cows with subclinical ketosis].
    Veterinarno-meditsinski nauki, 1983, Volume: 20, Issue:3-4

    Topics: Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Dose-Response Relationship, Drug; Drug Ev

1983
Xylazine causes transient dose-related hyperglycemia and increased urine volumes in mares.
    American journal of veterinary research, 1984, Volume: 45, Issue:2

    Topics: Analgesia; Animals; Blood Glucose; Cattle; Female; Horse Diseases; Horses; Hyperglycemia; Thiazines;

1984
Effect of adrenergic drugs on glucose and plasma glucagon and insulin responses to xylazine in sheep.
    Research in veterinary science, 1982, Volume: 33, Issue:1

    Topics: Animals; Blood Glucose; Glucagon; Hyperglycemia; Insulin; Phentolamine; Propranolol; Sheep; Sheep Di

1982
Hyperglycemia and the vascular effects of cerebral ischemia.
    Stroke, 1997, Volume: 28, Issue:1

    Topics: Anesthetics; Animals; Blood Glucose; Body Temperature; Cerebral Arteries; Cerebral Hemorrhage; Cereb

1997
Xylazine-induced hyperglycemia in beef cattle.
    American journal of veterinary research, 1979, Volume: 40, Issue:1

    Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Cattle; Cattle Diseases; Hyperglycemia; Insulin; Male;

1979
The role of hypoxia in the hyperglycaemic effect of xylazine in sheep.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1990, Volume: 37, Issue:3

    Topics: Animals; Blood Gas Analysis; Hyperglycemia; Hypoxia; Male; Sheep; Sheep Diseases; Thiazines; Xylazin

1990
Xylazine-induced hyperglycaemia and alpha-adrenergic receptors in sheep.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1987, Volume: 34, Issue:1

    Topics: Animals; Blood Glucose; Female; Hyperglycemia; Receptors, Adrenergic, alpha; Sheep; Sheep Diseases;

1987
Effect of yohimbine on xylazine-induced hypoinsulinemia and hyperglycemia in mares.
    American journal of veterinary research, 1987, Volume: 48, Issue:4

    Topics: Animals; Blood Glucose; Female; Horse Diseases; Horses; Hyperglycemia; Insulin; Thiazines; Xylazine;

1987