xylazine has been researched along with Drug Overdose in 31 studies
Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths." | 8.31 | Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023) |
| "Illicit opioids, consisting largely of fentanyl, novel synthetic opioids, and adulterants, are the primary cause of drug overdose fatality in the United States." | 4.31 | Opioid overdoses involving xylazine in emergency department patients: a multicenter study. ( Aldy, K; Amaducci, A; Brent, J; Calello, D; Hendrickson, R; Hughes, A; Judge, B; Krotulski, AJ; Kurt, A; Levine, M; Logan, BK; Love, JS; Manini, AF; Pizon, A; Schwarz, E; Shulman, J; Vargas-Torres, C; Walton, SE; Wax, P; Wiegan, T, 2023) |
| "These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths." | 4.31 | Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023) |
| "In 2022, provisional data indicated that more than two thirds (68%) of the reported 107,081 drug overdose deaths in the United States involved synthetic opioids other than methadone, principally illicitly manufactured fentanyls (IMFs) (1)." | 4.31 | Illicitly Manufactured Fentanyl-Involved Overdose Deaths with Detected Xylazine - United States, January 2019-June 2022. ( Goldberger, BA; Kariisa, M; Kumar, S; Mattson, CL; O'Donnell, J, 2023) |
| "Xylazine is an animal sedative, approved by the U." | 3.01 | Xylazine Adulteration of the Heroin-Fentanyl Drug Supply : A Narrative Review. ( D'Orazio, J; Haroz, R; Nelson, L; Perrone, J; Wightman, R, 2023) |
| "The National Programme on Substance Abuse Deaths (NPSAD) receives reports on drug-related deaths from coroners In England, Wales and Northern Ireland on a voluntary basis." | 1.91 | The first drug-related death associated with xylazine use in the UK and Europe. ( Copeland, CS; Duffy, J; Lawson, AJ; Mellor, A; Rock, KL; Treble, R, 2023) |
| "Fentanyl was detected in 67." | 1.91 | Comprehensive testing and rapid dissemination of local drug supply surveillance data in Rhode Island. ( Badea, A; Collins, AB; Elmaleh, R; Guan, Y; Krieger, M; Macon, EC; Morales, A; Shihipar, A; Smith, MC; Wightman, RS, 2023) |
| "Fentanyl was detected primarily in powder forms of methamphetamine and cocaine." | 1.91 | Prevalence of fentanyl in methamphetamine and cocaine samples collected by community-based drug checking services. ( Dasgupta, N; Fiuty, P; Miller, CW; Nocera, M; Page, K; Tarhuni, LJ; Tracy, EC; Wagner, KD, 2023) |
| "Xylazine is an unscheduled non-opioid indicated as a veterinary tranquilizer, also known as "Tranq." | 1.91 | Xylazine: The Drug Taking the World By Storm: What You Need to Know. ( Brown, W; Mumba, MN; Tice, J, 2023) |
| "Xylazine is a veterinary tranquilizer, long noted in the street opioid supply of Puerto Rico, and more recently Philadelphia." | 1.72 | Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis. ( Bourgois, P; Dye, D; Friedman, J; Goodman-Meza, D; Montero, F; Shover, C; Wahbi, R, 2022) |
| "5 years (January 2019-June 2021) of driving under the influence of drugs (DUID) and medico-legal death investigation (MDI) cases was investigated, including other drugs detected in combination with xylazine." | 1.72 | Xylazine: Pharmacology Review and Prevalence and Drug Combinations in Forensic Toxicology Casework. ( Barbieri, EJ; Kacinko, SL; Logan, BK; Mohr, ALA, 2022) |
| "Xylazine is an emerging adulterant with fentanyl in fatal drug intoxications, which has public health, safety, and criminal investigative implications." | 1.62 | Xylazine, a Veterinary Tranquilizer, Detected in 42 Accidental Fentanyl Intoxication Deaths. ( DeJoseph, ME; Gill, JR; Nunez, J, 2021) |
| "Xylazine is a sedative, analgesic, anesthetic, and central muscle relaxant approved for animals but not humans." | 1.43 | Xylazine Exposures Reported to Texas Poison Centers. ( Forrester, MB, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 27 (87.10) | 2.80 |
| Authors | Studies |
|---|---|
| Thangada, S | 1 |
| Clinton, HA | 1 |
| Ali, S | 1 |
| Nunez, J | 2 |
| Gill, JR | 2 |
| Lawlor, RF | 1 |
| Logan, SB | 1 |
| Kariisa, M | 2 |
| Patel, P | 1 |
| Smith, H | 1 |
| Bitting, J | 1 |
| Bowles, JM | 1 |
| McDonald, K | 1 |
| Maghsoudi, N | 1 |
| Thompson, H | 1 |
| Stefan, C | 1 |
| Beriault, DR | 1 |
| Delaney, S | 1 |
| Wong, E | 1 |
| Werb, D | 1 |
| Friedman, J | 1 |
| Montero, F | 1 |
| Bourgois, P | 1 |
| Wahbi, R | 1 |
| Dye, D | 1 |
| Goodman-Meza, D | 1 |
| Shover, C | 1 |
| Kacinko, SL | 1 |
| Mohr, ALA | 1 |
| Logan, BK | 2 |
| Barbieri, EJ | 1 |
| Alexander, RS | 1 |
| Canver, BR | 1 |
| Sue, KL | 1 |
| Morford, KL | 1 |
| Sibbesen, J | 2 |
| Abate, MA | 2 |
| Dai, Z | 2 |
| Smith, GS | 2 |
| Lundstrom, E | 2 |
| Kraner, JC | 2 |
| Mock, AR | 2 |
| Deutsch, SA | 1 |
| De Jong, AR | 1 |
| Aschenbrenner, DS | 1 |
| Love, JS | 1 |
| Levine, M | 1 |
| Aldy, K | 1 |
| Brent, J | 1 |
| Krotulski, AJ | 1 |
| Vargas-Torres, C | 1 |
| Walton, SE | 1 |
| Amaducci, A | 1 |
| Calello, D | 1 |
| Hendrickson, R | 1 |
| Hughes, A | 1 |
| Kurt, A | 1 |
| Judge, B | 1 |
| Pizon, A | 1 |
| Schwarz, E | 1 |
| Shulman, J | 1 |
| Wiegan, T | 1 |
| Wax, P | 1 |
| Manini, AF | 1 |
| Russell, E | 1 |
| Sisco, E | 1 |
| Thomson, A | 1 |
| Lopes, J | 1 |
| Rybak, M | 1 |
| Burnett, M | 1 |
| Heilman, D | 1 |
| Appley, MG | 1 |
| Gladden, RM | 1 |
| Rock, KL | 1 |
| Lawson, AJ | 1 |
| Duffy, J | 1 |
| Mellor, A | 1 |
| Treble, R | 1 |
| Copeland, CS | 1 |
| Choi, S | 1 |
| Irwin, MR | 1 |
| Kiyatkin, EA | 1 |
| Delcher, C | 1 |
| Anthony, N | 1 |
| Mir, M | 1 |
| O'Donnell, J | 1 |
| Kumar, S | 1 |
| Mattson, CL | 1 |
| Goldberger, BA | 1 |
| Collins, AB | 1 |
| Wightman, RS | 1 |
| Macon, EC | 1 |
| Guan, Y | 1 |
| Shihipar, A | 1 |
| Krieger, M | 1 |
| Elmaleh, R | 1 |
| Smith, MC | 1 |
| Morales, A | 1 |
| Badea, A | 1 |
| Korona-Bailey, J | 1 |
| Onyango, E | 1 |
| Hall, KF | 1 |
| Jayasundara, J | 1 |
| Mukhopadhyay, S | 1 |
| Friedman, NMG | 1 |
| Molina, CA | 1 |
| Glenn, MJ | 1 |
| Potoukian, RB | 1 |
| Gonyea, J | 1 |
| Shoff, EN | 1 |
| Hime, GW | 1 |
| Moore, DM | 1 |
| Zhu, DT | 1 |
| Vega, IL | 1 |
| Griswold, MK | 1 |
| O'Gurek, DT | 1 |
| D'Orazio, J | 1 |
| Nelson, L | 1 |
| Perrone, J | 1 |
| Wightman, R | 1 |
| Haroz, R | 1 |
| Wagner, KD | 1 |
| Fiuty, P | 1 |
| Page, K | 1 |
| Tracy, EC | 1 |
| Nocera, M | 1 |
| Miller, CW | 1 |
| Tarhuni, LJ | 1 |
| Dasgupta, N | 1 |
| Leconte, CE | 1 |
| Sethi, R | 1 |
| Mumba, MN | 1 |
| Tice, J | 1 |
| Brown, W | 1 |
| DeJoseph, ME | 1 |
| Johnson, J | 1 |
| Pizzicato, L | 1 |
| Johnson, C | 1 |
| Viner, K | 1 |
| Forrester, MB | 1 |
| Elejalde, JI | 1 |
| Louis, CJ | 1 |
| Elcuaz, R | 1 |
| Pinillos, MA | 1 |
| Capraro, AJ | 1 |
| Wiley, JF | 1 |
| Tucker, JR | 1 |
| Van Metre, DC | 1 |
3 reviews available for xylazine and Drug Overdose
| Article | Year |
|---|---|
Public health impact and harm reduction implications of xylazine-involved overdoses: a narrative review.
Topics: Alberta; Drug Overdose; Harm Reduction; Humans; Public Health; Xylazine | 2023 |
Xylazine Adulteration of the Heroin-Fentanyl Drug Supply : A Narrative Review.
Topics: Analgesics, Opioid; Animals; Drug Overdose; Fentanyl; Heroin; Humans; Illicit Drugs; Pharmaceutical | 2023 |
Severe intoxication from xylazine inhalation.
Topics: Administration, Inhalation; Adolescent; Adrenergic alpha-Agonists; Coma; Drug Overdose; Humans; Male | 2001 |
28 other studies available for xylazine and Drug Overdose
| Article | Year |
|---|---|
Notes from the Field: Xylazine, a Veterinary Tranquilizer, Identified as an Emerging Novel Substance in Drug Overdose Deaths - Connecticut, 2019-2020.
Topics: Adult; Connecticut; Drug Overdose; Female; Humans; Male; Middle Aged; Tranquilizing Agents; Veterina | 2021 |
Notes from the Field: Xylazine Detection and Involvement in Drug Overdose Deaths - United States, 2019.
Topics: Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Male; Middle Aged; United States; Xylazine; | 2021 |
Xylazine detected in unregulated opioids and drug administration equipment in Toronto, Canada: clinical and social implications.
Topics: Analgesics, Opioid; Canada; Drug Overdose; Fentanyl; Humans; Illicit Drugs; Pharmaceutical Preparati | 2021 |
Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Heroin; Humans; Substance Abuse, Intravenous; Xylazine | 2022 |
Xylazine: Pharmacology Review and Prevalence and Drug Combinations in Forensic Toxicology Casework.
Topics: Analgesics, Opioid; Benzodiazepines; Cannabinoids; Drug Combinations; Drug Overdose; Fentanyl; Foren | 2022 |
Xylazine and Overdoses: Trends, Concerns, and Recommendations.
Topics: Analgesics, Opioid; Drug Overdose; Harm Reduction; Humans; Illicit Drugs; Opiate Overdose; Public He | 2022 |
Characteristics of xylazine-related deaths in West Virginia-Xylazine-related deaths.
Topics: Drug Overdose; Fentanyl; Humans; West Virginia; Xylazine | 2023 |
Characteristics of xylazine-related deaths in West Virginia-Xylazine-related deaths.
Topics: Drug Overdose; Fentanyl; Humans; West Virginia; Xylazine | 2023 |
Characteristics of xylazine-related deaths in West Virginia-Xylazine-related deaths.
Topics: Drug Overdose; Fentanyl; Humans; West Virginia; Xylazine | 2023 |
Characteristics of xylazine-related deaths in West Virginia-Xylazine-related deaths.
Topics: Drug Overdose; Fentanyl; Humans; West Virginia; Xylazine | 2023 |
Xylazine Complicating Opioid Ingestions in Young Children.
Topics: Adult; Analgesics, Opioid; Child; Child, Preschool; Drug Overdose; Humans; Naloxone; Respiratory Ins | 2023 |
Illicit Drugs May Contain Veterinary Tranquilizer.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Illicit Drugs; Naloxone; Xylazine | 2023 |
Opioid overdoses involving xylazine in emergency department patients: a multicenter study.
Topics: Adult; Analgesics, Opioid; Coma; Drug Overdose; Emergency Service, Hospital; Fentanyl; Humans; Opiat | 2023 |
Rapid Analysis of Drugs: A Pilot Surveillance System To Detect Changes in the Illicit Drug Supply To Guide Timely Harm Reduction Responses - Eight Syringe Services Programs, Maryland, November 2021-August 2022.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Harm Reduction; Humans; Illicit Drugs; Maryland; Xylazi | 2023 |
The first drug-related death associated with xylazine use in the UK and Europe.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Europe; Fentanyl; Heroin; Humans; Illicit Drugs; Male; Pha | 2023 |
Xylazine effects on opioid-induced brain hypoxia.
Topics: Analgesics, Opioid; Animals; Drug Overdose; Fentanyl; Heroin; Humans; Hypothermia; Hypoxia; Hypoxia, | 2023 |
Xylazine-involved fatal overdoses and localized geographic clustering: Cook County, IL, 2019-2022.
Topics: Analgesics; Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Illinois; Xylazine | 2023 |
Illicitly Manufactured Fentanyl-Involved Overdose Deaths with Detected Xylazine - United States, January 2019-June 2022.
Topics: District of Columbia; Drug Overdose; Fentanyl; Humans; Opiate Overdose; United States; Xylazine | 2023 |
Comprehensive testing and rapid dissemination of local drug supply surveillance data in Rhode Island.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Rhode Island; United States; Xylazine | 2023 |
Xylazine-Involved Fatal and Nonfatal Drug Overdoses in Tennessee From 2019 to 2022.
Topics: Analgesics, Opioid; Drug Overdose; Humans; Tennessee; Xylazine | 2023 |
Harm reduction and emergency medical services: Opportunities for evidence-based programming.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Harm Reduction; Heroin; Humans; Xylazine | 2023 |
Prevalence of xylazine in overdose cases: An analysis of Miami-Dade County medical examiner case data.
Topics: Adult; Analgesics, Opioid; Central Nervous System Depressants; Coroners and Medical Examiners; Drug | 2023 |
The Role of Xylazine in the Overdose Crisis.
Topics: Drug Overdose; Humans; Xylazine | 2023 |
Prevalence of fentanyl in methamphetamine and cocaine samples collected by community-based drug checking services.
Topics: Analgesics, Opioid; Central Nervous System Stimulants; Cocaine; Community Health Services; Crack Coc | 2023 |
The Appearance of Xylazine in the United States as a Fentanyl Adulterant.
Topics: Bradycardia; Drug Overdose; Fentanyl; Humans; Naloxone; United States; Xylazine | 2023 |
Xylazine: The Drug Taking the World By Storm: What You Need to Know.
Topics: Cocaine; Drug Overdose; Humans; Pharmaceutical Preparations; United States; Xylazine | 2023 |
Xylazine, a Veterinary Tranquilizer, Detected in 42 Accidental Fentanyl Intoxication Deaths.
Topics: Accidents; Adult; Analgesics, Opioid; Chromatography, Liquid; Connecticut; Coroners and Medical Exam | 2021 |
Increasing presence of xylazine in heroin and/or fentanyl deaths, Philadelphia, Pennsylvania, 2010-2019.
Topics: Drug Overdose; Fentanyl; Heroin; Humans; Philadelphia; United States; Xylazine | 2021 |
Xylazine Exposures Reported to Texas Poison Centers.
Topics: Adolescent; Adult; Age Distribution; Aged; Child; Drug Administration Routes; Drug Overdose; Female; | 2016 |
Drug abuse with inhalated xylazine.
Topics: Adolescent; Drug Overdose; Humans; Male; Substance-Related Disorders; Xylazine | 2003 |
A case report of the treatment of an overdose of xylazine in a cow.
Topics: Animals; Atropine; Bradycardia; Cattle; Cattle Diseases; Drug Overdose; Female; Fluid Therapy; Heart | 1992 |