Page last updated: 2024-11-05

xylazine and Anoxemia

xylazine has been researched along with Anoxemia in 19 studies

Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.

Research Excerpts

ExcerptRelevanceReference
"These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths."8.31Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023)
"These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths."4.31Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023)
"Ketamine is often used in combination with tranquilizers to produce surgical anesthesia in rabbits."3.68Ketamine/xylazine/butorphanol: a new anesthetic combination for rabbits. ( Avison, DL; Corning, BF; Lipman, NS; Marini, RP, 1992)
"ketamine dosages were evaluated: 0."2.72Effects of ketamine on carfentanil and xylazine immobilization of white-tailed deer (Odocoileus virginianus). ( Miller, KV; Osborn, DA; Ramsay, EC; Schumacher, J; Storms, TN, 2006)
"The purpose of this study was to examine the effects of a clinically relevant opioid on the production of augmented breaths (ABs) in unanesthetized animals breathing normal room air, using a dosage which does not depress breathing."1.37The "other" respiratory effect of opioids: suppression of spontaneous augmented ("sigh") breaths. ( Azubike, E; Bell, HJ; Haouzi, P, 2011)
"Anesthetized animals showed profound hypoxemia with mild hypercapnia, tachycardia, hypertension, and acidosis prior to naloxone administration."1.31Use of naloxone to reverse carfentanil citrate-induced hypoxemia and cardiopulmonary depression in Rocky Mountain wapiti (Cervus elaphus nelsoni). ( Gaynor, JS; Larsen, RS; Moresco, A; Sleeman, JM; Wild, MA, 2001)
"All wapiti exhibited mild to marked hypoxemia (PaO2 = 43 +/- 11."1.31Treatment of hypoxemia during xylazine-tiletamine-zolazepam immobilization of wapiti. ( Caulkett, NA; Read, MR; Shury, TK; Symington, A, 2001)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.26)18.7374
1990's5 (26.32)18.2507
2000's6 (31.58)29.6817
2010's4 (21.05)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
David, EM1
Pacharinsak, C1
Jampachaisri, K1
Hagan, L1
Marx, JO1
Choi, S1
Irwin, MR1
Kiyatkin, EA1
Cardoso, CG1
Ayer, IM1
Jorge, AT1
Honsho, CS1
Mattos-Junior, E1
Singh, PM1
Reid, K1
Gaddam, R1
Bhatia, M1
Smith, S1
Jacob, A1
Chambers, P1
Hopster, K1
Wittenberg-Voges, L1
Geburek, F1
Hopster-Iversen, C1
Kästner, SBR1
Lian, M1
Björck, S1
Arnemo, JM1
Esteruelas, NF1
Angel, M1
Minsaas, SC1
Jones, KL1
L Evans, A1
Bell, HJ1
Azubike, E1
Haouzi, P1
Moresco, A1
Larsen, RS1
Sleeman, JM1
Wild, MA1
Gaynor, JS1
Oku, K1
Yamanaka, T1
Ashihara, N1
Kawasaki, K1
Mizuno, Y1
Fujinaga, T1
Storms, TN1
Schumacher, J1
Osborn, DA1
Miller, KV1
Ramsay, EC1
Ko, JC1
Payton, M1
Weil, AB1
Kitao, T1
Haydon, T1
Celly, CS1
McDonell, WN1
Young, SS1
Black, WD1
Jones, JG1
Caulkett, NA2
Cribb, PH1
Haigh, JC1
Read, MR1
Symington, A1
Shury, TK1
Marini, RP1
Avison, DL1
Corning, BF1
Lipman, NS1
Raptopoulos, D1
Nolan, AM1
Callingham, BA1
Evans, RJ1
Bowman, A1
McGrath, JC1

Trials

4 trials available for xylazine and Anoxemia

ArticleYear
Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep.
    Veterinary anaesthesia and analgesia, 2017, Volume: 44, Issue:5

    Topics: Analgesics; Animals; Blood Gas Analysis; Choline; Female; Hypoxia; Mice; Preanesthetic Medication; R

2017
Clinical observations during induction and recovery of xylazine-midazolam- propofol anesthesia in horses.
    The Journal of veterinary medical science, 2003, Volume: 65, Issue:7

    Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Blood Pressu

2003
Effects of ketamine on carfentanil and xylazine immobilization of white-tailed deer (Odocoileus virginianus).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2006, Volume: 37, Issue:3

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Animals, Wild; Bl

2006
Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs.
    Veterinary therapeutics : research in applied veterinary medicine, 2007,Summer, Volume: 8, Issue:2

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthet

2007

Other Studies

15 other studies available for xylazine and Anoxemia

ArticleYear
Use of Ketamine or Xylazine to Provide Balanced Anesthesia with Isoflurane in C57BL/6J Mice.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2022, 09-01, Volume: 61, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Balanced Anesthesia; Crystalloid Solutions; Female; Hypovolemia; H

2022
Xylazine effects on opioid-induced brain hypoxia.
    Psychopharmacology, 2023, Volume: 240, Issue:7

    Topics: Analgesics, Opioid; Animals; Drug Overdose; Fentanyl; Heroin; Humans; Hypothermia; Hypoxia; Hypoxia,

2023
A comparative study of the cardiopulmonary and sedative effects of a single intramuscular dose of ketamine anesthetic combinations in rabbits.
    Research in veterinary science, 2020, Volume: 128

    Topics: Acepromazine; Anesthesia; Anesthesia Recovery Period; Anesthetics; Animals; Arterial Pressure; Cross

2020
Effects of controlled hypoxemia or hypovolemia on global and intestinal oxygenation and perfusion in isoflurane anesthetized horses receiving an alpha-2-agonist infusion.
    BMC veterinary research, 2017, Nov-28, Volume: 13, Issue:1

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Dexmedetomidine; Female; Heart Rate; Horse

2017
Severe Hypoxemia in Muskoxen ( Ovibos moschatus ) Immobilized with Etorphine and Xylazine Corrected with Supplemental Nasal Oxygen.
    Journal of wildlife diseases, 2017, Volume: 53, Issue:2

    Topics: Animals; Etorphine; Hypnotics and Sedatives; Hypoxia; Immobilization; Oximetry; Oxygen; Ruminants; S

2017
The "other" respiratory effect of opioids: suppression of spontaneous augmented ("sigh") breaths.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:5

    Topics: Analgesics, Opioid; Animals; Hypnotics and Sedatives; Hypoxia; Ketamine; Male; Morphine; Naloxone; R

2011
Use of naloxone to reverse carfentanil citrate-induced hypoxemia and cardiopulmonary depression in Rocky Mountain wapiti (Cervus elaphus nelsoni).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2001, Volume: 32, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Blood Gas Analysis; Cross-Over Studies; Deer

2001
The comparative hypoxaemic effect of four alpha 2 adrenoceptor agonists (xylazine, romifidine, detomidine and medetomidine) in sheep.
    Journal of veterinary pharmacology and therapeutics, 1997, Volume: 20, Issue:6

    Topics: Adrenergic alpha-Agonists; Analgesics; Anesthetics; Animals; Female; Hemodynamics; Hypoxia; Imidazol

1997
Alpha-2 receptor agonists and a species-specific mechanism of hypoxaemia.
    Anaesthesia, 1999, Volume: 54, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Hypoxia; Sheep; Sheep Diseases; Species Specificity; Xylazine

1999
Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for immobilization of mule deer and mule deer/white-tailed deer hybrids.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2000, Volume: 64, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animal Welfare; Animals; A

2000
Treatment of hypoxemia during xylazine-tiletamine-zolazepam immobilization of wapiti.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2001, Volume: 42, Issue:11

    Topics: Adrenergic alpha-Agonists; Anesthetics, Dissociative; Animals; Animals, Wild; Anti-Anxiety Agents; B

2001
Ketamine/xylazine/butorphanol: a new anesthetic combination for rabbits.
    Laboratory animal science, 1992, Volume: 42, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Butorphanol; Dose-Response Relationship, Drug; Drug Combination

1992
The role of hypoxia in the hyperglycaemic effect of xylazine in sheep.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1990, Volume: 37, Issue:3

    Topics: Animals; Blood Gas Analysis; Hyperglycemia; Hypoxia; Male; Sheep; Sheep Diseases; Thiazines; Xylazin

1990
Effects of aspirin on xylazine-induced hypoxaemia in sheep.
    Research in veterinary science, 1990, Volume: 48, Issue:3

    Topics: Animals; Aspirin; Female; Hypoxia; Injections, Intravenous; Male; Oxygen; Platelet Aggregation; Plat

1990
The effect of hypoxia on neuroeffector transmission in the bovine retractor penis and rat anococcygeus muscles.
    British journal of pharmacology, 1985, Volume: 85, Issue:4

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Alprostadil; Animals; Cattle; Electric Stimulation; Guanethidine; G

1985