Page last updated: 2024-11-05

xylazine and Aging

xylazine has been researched along with Aging in 18 studies

Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results."5.43Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016)
"The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses."3.81Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats. ( Burns, P; Giroux, MC; Hélie, P; Vachon, P, 2015)
" Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results."1.43Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016)
" The rate constant of elimination of both drugs was greatly decreased and the elimination half-life was significantly greater in old compared with young rats."1.39Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats. ( Beaudry, F; Carrier, D; Castel, A; Vachon, P; Veilleux-Lemieux, D, 2013)
"Hydralazine treatment, which prevented the development of hypertension, attenuated the increased 3H overflow evoked by PNS in SHR."1.28Effect of chronically administered hydralazine on altered adrenergic neurotransmission mediated by presynaptic alpha- and beta-adrenoceptors in spontaneously hypertensive rats. ( Kato, H; Mochizuki, S; Takata, Y, 1990)
"Ketamine hydrochloride was administered intravenously to unpremedicated and xylazine-treated calves."1.27The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride. ( Waterman, AE, 1984)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19908 (44.44)18.7374
1990's5 (27.78)18.2507
2000's1 (5.56)29.6817
2010's4 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Veilleux-Lemieux, D1
Castel, A1
Carrier, D1
Beaudry, F2
Vachon, P3
Giroux, MC2
Hélie, P2
Burns, P2
Santamaria, R1
Cone, FE1
Steinhart, MR1
Oglesby, EN1
Kalesnykas, G1
Pease, ME1
Quigley, HA1
Chaves, AA1
Dech, SJ1
Nakayama, T1
Hamlin, RL1
Bauer, JA1
Carnes, CA1
MacDonald, A1
McGrath, JC1
Docherty, JR6
O'Malley, K2
Waterman, AE1
Roder, JD1
Shen, Y1
Sangiah, S1
Parsons, CH1
Rogers, LJ1
Takata, Y1
Mochizuki, S1
Kato, H1
Fleck, C1
Barth, A1
Hyland, L2
Tourai, K1
Senba, H1
Sasaki, N1
Tokuriki, M1
Ohashi, F1
Takeuchi, A1
Usui, K1

Reviews

1 review available for xylazine and Aging

ArticleYear
Ageing and alpha-adrenoceptors.
    Clinical science (London, England : 1979), 1985, Volume: 68 Suppl 10

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta; Blood Platelets; Hum

1985

Other Studies

17 other studies available for xylazine and Aging

ArticleYear
Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2013, Volume: 52, Issue:5

    Topics: Age Factors; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Drug Therapy, Combination; Human

2013
Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats.
    Experimental animals, 2015, Volume: 64, Issue:3

    Topics: Aging; Anesthesia; Animals; Body Temperature; Cornea; Drug Combinations; Heart Rate; Infusions, Pare

2015
Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia.
    Experimental animals, 2016, Volume: 65, Issue:1

    Topics: Aging; Anesthesia; Anesthetics; Animals; Blinking; Heart Rate; Injections, Intraperitoneal; Ketamine

2016
The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma.
    Experimental eye research, 2012, Volume: 99

    Topics: Acepromazine; Aging; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Axons;

2012
Age and anesthetic effects on murine electrocardiography.
    Life sciences, 2003, Apr-11, Volume: 72, Issue:21

    Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi

2003
Post-natal development of functional neurotransmission in rat vas deferens.
    British journal of pharmacology, 1984, Volume: 82, Issue:1

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male;

1984
An examination of age-related changes in pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens.
    European journal of pharmacology, 1983, Nov-25, Volume: 95, Issue:3-4

    Topics: Aging; Animals; Ethanolamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats;

1983
The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride.
    Journal of veterinary pharmacology and therapeutics, 1984, Volume: 7, Issue:2

    Topics: Aging; Animals; Cattle; Female; Half-Life; Injections, Intravenous; Ketamine; Kinetics; Male; Preane

1984
Effects of aging on prejunctional control of neurotransmission in the rat.
    Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786

    Topics: Adrenergic Fibers; Aging; Animals; Catecholamines; Clonidine; Male; Neurotransmitter Agents; Presyna

1996
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
    Veterinary and human toxicology, 1996, Volume: 38, Issue:3

    Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D

1996
Pharmacological extension of the sensitive period for imprinting in Gallus domesticus.
    Physiology & behavior, 1997, Volume: 62, Issue:6

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Chickens; Darkness; Excitatory Amino Ac

1997
Effect of chronically administered hydralazine on altered adrenergic neurotransmission mediated by presynaptic alpha- and beta-adrenoceptors in spontaneously hypertensive rats.
    Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:9

    Topics: Adrenergic Fibers; Aging; Animals; Blood Pressure; Drug Administration Schedule; Electric Stimulatio

1990
Influence of xenobiotics on bile flow and bile composition in rats--methodological approach.
    Experimental pathology, 1990, Volume: 39, Issue:3-4

    Topics: Aging; Anesthesia; Animals; Bile; Body Water; Cholesterol; Female; Ketamine; Methods; Nephrectomy; R

1990
The effects of ageing on vascular alpha-adrenoceptors in pithed rat and rat aorta.
    European journal of pharmacology, 1988, Jan-27, Volume: 146, Issue:1

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Aorta; Blood Pressure; Decerebrate State; Ethanolamines;

1988
Alpha-adrenoceptor responsiveness in the aged rat.
    European journal of pharmacology, 1986, Jul-15, Volume: 126, Issue:1-2

    Topics: Aging; Anesthesia; Animals; Blood Pressure; Cocaine; Decerebrate State; Ethanolamines; Heart Rate; M

1986
Further examination of the effects of ageing on the adrenoceptor responsiveness of the rat vas deferens.
    European journal of pharmacology, 1985, Apr-02, Volume: 110, Issue:2

    Topics: Aging; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; M

1985
Developmental EEG of the beagle dog under xylazine sedation.
    Nihon juigaku zasshi. The Japanese journal of veterinary science, 1985, Volume: 47, Issue:3

    Topics: Aging; Animals; Cerebral Cortex; Dogs; Electroencephalography; Immobilization; Thiazines; Xylazine

1985