xylazine has been researched along with Aging in 18 studies
Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results." | 5.43 | Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016) |
| "The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses." | 3.81 | Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats. ( Burns, P; Giroux, MC; Hélie, P; Vachon, P, 2015) |
| " Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results." | 1.43 | Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016) |
| " The rate constant of elimination of both drugs was greatly decreased and the elimination half-life was significantly greater in old compared with young rats." | 1.39 | Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats. ( Beaudry, F; Carrier, D; Castel, A; Vachon, P; Veilleux-Lemieux, D, 2013) |
| "Hydralazine treatment, which prevented the development of hypertension, attenuated the increased 3H overflow evoked by PNS in SHR." | 1.28 | Effect of chronically administered hydralazine on altered adrenergic neurotransmission mediated by presynaptic alpha- and beta-adrenoceptors in spontaneously hypertensive rats. ( Kato, H; Mochizuki, S; Takata, Y, 1990) |
| "Ketamine hydrochloride was administered intravenously to unpremedicated and xylazine-treated calves." | 1.27 | The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride. ( Waterman, AE, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Veilleux-Lemieux, D | 1 |
| Castel, A | 1 |
| Carrier, D | 1 |
| Beaudry, F | 2 |
| Vachon, P | 3 |
| Giroux, MC | 2 |
| Hélie, P | 2 |
| Burns, P | 2 |
| Santamaria, R | 1 |
| Cone, FE | 1 |
| Steinhart, MR | 1 |
| Oglesby, EN | 1 |
| Kalesnykas, G | 1 |
| Pease, ME | 1 |
| Quigley, HA | 1 |
| Chaves, AA | 1 |
| Dech, SJ | 1 |
| Nakayama, T | 1 |
| Hamlin, RL | 1 |
| Bauer, JA | 1 |
| Carnes, CA | 1 |
| MacDonald, A | 1 |
| McGrath, JC | 1 |
| Docherty, JR | 6 |
| O'Malley, K | 2 |
| Waterman, AE | 1 |
| Roder, JD | 1 |
| Shen, Y | 1 |
| Sangiah, S | 1 |
| Parsons, CH | 1 |
| Rogers, LJ | 1 |
| Takata, Y | 1 |
| Mochizuki, S | 1 |
| Kato, H | 1 |
| Fleck, C | 1 |
| Barth, A | 1 |
| Hyland, L | 2 |
| Tourai, K | 1 |
| Senba, H | 1 |
| Sasaki, N | 1 |
| Tokuriki, M | 1 |
| Ohashi, F | 1 |
| Takeuchi, A | 1 |
| Usui, K | 1 |
1 review available for xylazine and Aging
| Article | Year |
|---|---|
Ageing and alpha-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta; Blood Platelets; Hum | 1985 |
17 other studies available for xylazine and Aging
| Article | Year |
|---|---|
Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats.
Topics: Age Factors; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Drug Therapy, Combination; Human | 2013 |
Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats.
Topics: Aging; Anesthesia; Animals; Body Temperature; Cornea; Drug Combinations; Heart Rate; Infusions, Pare | 2015 |
Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia.
Topics: Aging; Anesthesia; Anesthetics; Animals; Blinking; Heart Rate; Injections, Intraperitoneal; Ketamine | 2016 |
The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma.
Topics: Acepromazine; Aging; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Axons; | 2012 |
Age and anesthetic effects on murine electrocardiography.
Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi | 2003 |
Post-natal development of functional neurotransmission in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; | 1984 |
An examination of age-related changes in pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens.
Topics: Aging; Animals; Ethanolamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; | 1983 |
The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride.
Topics: Aging; Animals; Cattle; Female; Half-Life; Injections, Intravenous; Ketamine; Kinetics; Male; Preane | 1984 |
Effects of aging on prejunctional control of neurotransmission in the rat.
Topics: Adrenergic Fibers; Aging; Animals; Catecholamines; Clonidine; Male; Neurotransmitter Agents; Presyna | 1996 |
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D | 1996 |
Pharmacological extension of the sensitive period for imprinting in Gallus domesticus.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Chickens; Darkness; Excitatory Amino Ac | 1997 |
Effect of chronically administered hydralazine on altered adrenergic neurotransmission mediated by presynaptic alpha- and beta-adrenoceptors in spontaneously hypertensive rats.
Topics: Adrenergic Fibers; Aging; Animals; Blood Pressure; Drug Administration Schedule; Electric Stimulatio | 1990 |
Influence of xenobiotics on bile flow and bile composition in rats--methodological approach.
Topics: Aging; Anesthesia; Animals; Bile; Body Water; Cholesterol; Female; Ketamine; Methods; Nephrectomy; R | 1990 |
The effects of ageing on vascular alpha-adrenoceptors in pithed rat and rat aorta.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Aorta; Blood Pressure; Decerebrate State; Ethanolamines; | 1988 |
Alpha-adrenoceptor responsiveness in the aged rat.
Topics: Aging; Anesthesia; Animals; Blood Pressure; Cocaine; Decerebrate State; Ethanolamines; Heart Rate; M | 1986 |
Further examination of the effects of ageing on the adrenoceptor responsiveness of the rat vas deferens.
Topics: Aging; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; M | 1985 |
Developmental EEG of the beagle dog under xylazine sedation.
Topics: Aging; Animals; Cerebral Cortex; Dogs; Electroencephalography; Immobilization; Thiazines; Xylazine | 1985 |