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xylazine and Ache

xylazine has been researched along with Ache in 35 studies

Xylazine: An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
xylazine : A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.

Research Excerpts

ExcerptRelevanceReference
"A comparison of the analgesic potency of the alpha 2-adrenoceptor agonist, xylazine, in control healthy sheep and sheep suffering chronic pain from footrot, indicated that the analgesic effectiveness of xylazine was significantly reduced in the animals experiencing chronic pain."7.68The influence of chronic pain on the analgesic effects of the alpha 2-adrenoceptor agonist, xylazine, in sheep. ( Ley, S; Livingston, A; Waterman, A, 1991)
"A comparison of the analgesic potency of the alpha 2-adrenoceptor agonist, xylazine, in control healthy sheep and sheep suffering chronic pain from footrot, indicated that the analgesic effectiveness of xylazine was significantly reduced in the animals experiencing chronic pain."3.68The influence of chronic pain on the analgesic effects of the alpha 2-adrenoceptor agonist, xylazine, in sheep. ( Ley, S; Livingston, A; Waterman, A, 1991)
"of xylazine was injected IA, and blood samples were taken to assess drug systemic absorption."2.79A pharmacokinetic/clinical approach to postulate a local action of intra-articular xylazine administration in the horse: a preliminary study. ( Bazzica, C; Cagnardi, P; Della Rocca, G; Di Salvo, A; Giontella, A; Nannarone, S, 2014)
"To evaluate antinociceptive and selected effects associated with IM administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas."2.78Physiologic and antinociceptive effects following intramuscular administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas. ( Doherty, TJ; Egger, CM; Elliot, SB; Seddighi, R; Whitlock, BK, 2013)
"Xylazine-treated groups had higher cortisol than saline-treated animals and showed no differences among them at any time."1.36Effect of hot-iron disbudding on behaviour and plasma cortisol of calves sedated with xylazine. ( Broom, DM; Carolino, N; Carvalho, RC; Lima, MS; Stilwell, G, 2010)
"Xylazine is an alpha(2)-adrenoceptor agonist extensively used in veterinary and animal experimentation."1.35Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine. ( de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR, 2009)
"Xylazine was administered 20 minutes after EA was performed."1.35Physiologic effects of electroacupuncture combined with intramuscular administration of xylazine to provide analgesia in goats. ( Chen, JG; Chen, X; Ding, MX; Ding, Y; Hu, CM; Liu, DM; Zhou, ZY, 2009)
"Decreased pain was correlated with increased motor activity for morphine and amphetamine, and with decreased activity for xylazine and acepromazine; dipyrone and indomethacin did not alter activity levels."1.31The formalin test in the mouse: a parametric analysis of scoring properties. ( Abbott, FV; Saddi, GM, 2000)
" Intramuscular xylazine appears to be an effective analgesic agent for acute pain in the sheep and further investigation into ideal administration regimens and dosage may provide more detailed information on relationships between dose, analgesic and sedative effects."1.29Efficacy of intra-muscular analgesics for acute pain in sheep. ( Grant, C; Kuchel, TR; Upton, RN, 1996)
"Xylazine and morphine were included in the studies for comparison."1.27Antinociceptive activity and mechanism of action of detomidine. ( Virtanen, R, 1986)
"Colic was produced by inflating a balloon in the horses' cecum."1.27Visceral analgesia: effects of xylazine, butorphanol, meperidine, and pentazocine in horses. ( Muir, WW; Robertson, JT, 1985)
"Xylazine was significantly more effective in obtunding deep pain (P less than 0."1.26Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19905 (14.29)18.7374
1990's7 (20.00)18.2507
2000's8 (22.86)29.6817
2010's12 (34.29)24.3611
2020's3 (8.57)2.80

Authors

AuthorsStudies
Reedman, CN1
Duffield, TF1
DeVries, TJ1
Lissemore, KD1
Winder, CB1
Sato, A1
Sugiura, T1
Kosenda, K1
Murakami, T1
Floriano, D1
Gorenberg, E1
Watkins, A1
Hopster, K1
Oguntoye, CO1
Oyewande, OA1
Afolabi, OO1
Samimi, AS1
Sakhaee, E1
Iranmanesh, F1
Romero, TR2
Pacheco, Dda F1
Duarte, ID1
Seddighi, R2
Elliot, SB2
Whitlock, BK2
Egger, CM2
Doherty, TJ2
Di Salvo, A1
Della Rocca, G1
Bazzica, C1
Giontella, A1
Cagnardi, P1
Nannarone, S1
Lizarraga, I2
Castillo-Alcala, F1
Vasseur, E1
Rushen, J1
de Passillé, AM1
Bates, AJ1
Eder, P1
Laven, RA1
Singh, V1
Kinjavdekar, P1
Aithal, HP1
de Castro Perez, A1
de Francischi, JN1
Gama Duarte, ID1
Gehring, R2
Coetzee, JF2
Tarus-Sang, J2
Apley, MD1
Rohrbach, H1
Korpivaara, T1
Schatzmann, U1
Spadavecchia, C1
Stilwell, G1
Carvalho, RC1
Carolino, N1
Lima, MS1
Broom, DM1
Liu, DM1
Zhou, ZY1
Ding, Y1
Chen, JG1
Hu, CM1
Chen, X1
Ding, MX1
Anderson, DE1
Beths, T1
Magdalena, CM1
Navarro, VP1
Park, DM1
Stuani, MB1
Rocha, MJ1
Bertollo, CM1
Oliveira, AC1
Rocha, LT1
Costa, KA1
Nascimento, EB1
Coelho, MM1
Freire, AC1
Leonhardt, JH1
Skarda, RT2
Muir, WW3
Grant, C1
Upton, RN1
Kuchel, TR1
Abbott, FV2
Bonder, M1
Grondahl-Nielsen, C1
Simonsen, HB1
Lund, JD1
Hesselholt, M1
Saddi, GM1
Pippi, NL1
Lumb, WV1
Bennett, GJ1
Ochoa, JL1
Ley, S1
Waterman, A1
Livingston, A1
Wixson, SK1
White, WJ1
Hughes, HC1
Marshall, WK1
Lang, CM1
Virtanen, R1
Robertson, JT1

Reviews

1 review available for xylazine and Ache

ArticleYear
Graduate Student Literature Review: Role of pain mitigation on the welfare of dairy calves undergoing disbudding.
    Journal of dairy science, 2022, Volume: 105, Issue:8

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Horns; Humans; Pain; S

2022

Trials

12 trials available for xylazine and Ache

ArticleYear
The dilutional volume of morphine and xylazine administered via caudal epidural catheter affects cranial spread of analgesia in healthy standing horses.
    American journal of veterinary research, 2023, Dec-01, Volume: 84, Issue:12

    Topics: Analgesia, Epidural; Analgesics; Animals; Catheters; Female; Horses; Humans; Male; Morphine; Pain; P

2023
Evaluation of sedative, analgesic, physiological, and laboratory effects of two doses off medetomidine and xylazine in dromedary calves.
    Journal of veterinary pharmacology and therapeutics, 2019, Volume: 42, Issue:4

    Topics: Analgesia; Animals; Camelus; Conscious Sedation; Hypnotics and Sedatives; Male; Medetomidine; Pain;

2019
Physiologic and antinociceptive effects following intramuscular administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas.
    American journal of veterinary research, 2013, Volume: 74, Issue:4

    Topics: Animals; Camelids, New World; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combination

2013
Antinociceptive and selected physiological effects of morphine and xylazine on tiletamine-zolazepam anesthesia in llamas.
    Veterinary anaesthesia and analgesia, 2014, Volume: 41, Issue:4

    Topics: Anesthesia, Intravenous; Animals; Blood Pressure; Camelids, New World; Carbon Dioxide; Cross-Over St

2014
A pharmacokinetic/clinical approach to postulate a local action of intra-articular xylazine administration in the horse: a preliminary study.
    Journal of veterinary pharmacology and therapeutics, 2014, Volume: 37, Issue:5

    Topics: Analgesics; Animals; Arthroscopy; Horse Diseases; Horses; Injections, Intra-Articular; Joint Disease

2014
Sedative and mechanical hypoalgesic effects of butorphanol in xylazine-premedicated donkeys.
    Equine veterinary journal, 2015, Volume: 47, Issue:3

    Topics: Analgesics, Opioid; Animals; Butorphanol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug

2015
Effect of analgesia and anti-inflammatory treatment on weight gain and milk intake of dairy calves after disbudding.
    New Zealand veterinary journal, 2015, Volume: 63, Issue:3

    Topics: Analgesia; Anesthetics, Local; Animal Husbandry; Animals; Anti-Inflammatory Agents, Non-Steroidal; C

2015
Effect of bupivacaine on epidural analgesia produced by xylazine or medetomidine in buffaloes (Bubalus bubalis).
    Veterinary anaesthesia and analgesia, 2009, Volume: 36, Issue:1

    Topics: Analgesics; Animals; Buffaloes; Bupivacaine; Drug Interactions; Drug Therapy, Combination; Injection

2009
Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses.
    Veterinary anaesthesia and analgesia, 2009, Volume: 36, Issue:4

    Topics: Animals; Cross-Over Studies; Female; Forelimb; Hindlimb; Horses; Imidazoles; Male; Pain; Reflex; Tim

2009
A comparative study of xylazine-induced mechanical hypoalgesia in donkeys and horses.
    Veterinary anaesthesia and analgesia, 2012, Volume: 39, Issue:5

    Topics: Acepromazine; Analgesics; Animals; Area Under Curve; Cross-Over Studies; Dose-Response Relationship,

2012
Analgesic, hemodynamic, and respiratory effects of caudal epidurally administered xylazine hydrochloride solution in mares.
    American journal of veterinary research, 1996, Volume: 57, Issue:2

    Topics: Analysis of Variance; Anesthetics; Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Ca

1996
Options for management of acute pain in the rat.
    The Veterinary record, 1997, May-24, Volume: 140, Issue:21

    Topics: Acepromazine; Adjuvants, Anesthesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; B

1997

Other Studies

22 other studies available for xylazine and Ache

ArticleYear
Preoperative protocol for right flank laparotomy affects postoperative serum cortisol concentrations in dairy cows.
    Journal of the American Veterinary Medical Association, 2023, 09-01, Volume: 261, Issue:9

    Topics: Animals; Cattle; Female; Hydrocortisone; Laparotomy; Lidocaine; Pain; Xylazine

2023
Evaluation of Tramadol-Midazolam-Ketamine Anaesthesia in Rabbits.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2018, Dec-30, Volume: 33, Issue:2

    Topics: Anesthetics; Animals; Body Temperature; Heart Rate; Ketamine; Midazolam; Pain; Rabbits; Tramadol; Xy

2018
Xylazine induced central antinociception mediated by endogenous opioids and μ-opioid receptor, but not δ-or κ-opioid receptors.
    Brain research, 2013, Apr-19, Volume: 1506

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Male; Mice; Opioid Peptides; Pain; Pain Threshold; Re

2013
Short communication: calf body temperature following chemical disbudding with sedation: effects of milk allowance and supplemental heat.
    Journal of dairy science, 2014, Volume: 97, Issue:8

    Topics: Animal Husbandry; Animals; Animals, Newborn; Body Temperature; Cattle; Dairying; Female; Horns; Hot

2014
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
    European journal of pharmacology, 2009, Apr-17, Volume: 608, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals;

2009
Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub-anesthetic dose together with xylazine to calves prior to castration.
    Journal of veterinary pharmacology and therapeutics, 2009, Volume: 32, Issue:2

    Topics: Adrenergic alpha-Agonists; Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Chro

2009
Effect of hot-iron disbudding on behaviour and plasma cortisol of calves sedated with xylazine.
    Research in veterinary science, 2010, Volume: 88, Issue:1

    Topics: Animal Husbandry; Animals; Behavior, Animal; Cattle; Conscious Sedation; Dairying; Female; Horns; Hy

2010
Physiologic effects of electroacupuncture combined with intramuscular administration of xylazine to provide analgesia in goats.
    American journal of veterinary research, 2009, Volume: 70, Issue:11

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Dose-Response Relationship, Drug; Electroacupuncture

2009
Effect of sub-anesthetic xylazine and ketamine ('ketamine stun') administered to calves immediately prior to castration.
    Veterinary anaesthesia and analgesia, 2010, Volume: 37, Issue:6

    Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Dose-Response Relationship, Dru

2010
C-fos expression in rat brain nuclei following incisor tooth movement.
    Journal of dental research, 2004, Volume: 83, Issue:1

    Topics: Analgesics; Animals; Brain; Genes, fos; Incisor; Ketamine; Locus Coeruleus; Male; Models, Animal; Ne

2004
Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models.
    European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Body Temperature; Carrageenan; Dose

2006
Further studies on the xylazine-yohimbine interaction.
    Pharmacological research communications, 1984, Volume: 16, Issue:9

    Topics: Abdomen; Acetates; Acetic Acid; Animals; Kinetics; Male; Mice; Muscle Cramp; Pain; Receptors, Adrene

1984
Efficacy of intra-muscular analgesics for acute pain in sheep.
    Australian veterinary journal, 1996, Volume: 73, Issue:4

    Topics: Acute Disease; Analgesics; Animals; Female; Injections, Intramuscular; Male; Pain; Sheep; Sheep Dise

1996
Comparison of antinociceptive, cardiovascular, and respiratory effects, head ptosis, and position of pelvic limbs in mares after caudal epidural administration of xylazine and detomidine hydrochloride solution.
    American journal of veterinary research, 1996, Volume: 57, Issue:9

    Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Animals; Blood Pressure; Cardiac Output; Female; Hea

1996
Behavioural, endocrine and cardiac responses in young calves undergoing dehorning without and with use of sedation and analgesia.
    Veterinary journal (London, England : 1997), 1999, Volume: 158, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Local; Animals; Butorphanol; Cattle; Ele

1999
The formalin test in the mouse: a parametric analysis of scoring properties.
    Pain, 2000, Dec-15, Volume: 89, Issue:1

    Topics: Acepromazine; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Ani

2000
Objective tests of analgesic drugs in ponies.
    American journal of veterinary research, 1979, Volume: 40, Issue:8

    Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid

1979
Thermographic observations on rats with experimental neuropathic pain.
    Pain, 1991, Volume: 45, Issue:1

    Topics: Animals; Body Temperature; Cold Temperature; Male; Nervous System; Pain; Rats; Rats, Inbred Strains;

1991
The influence of chronic pain on the analgesic effects of the alpha 2-adrenoceptor agonist, xylazine, in sheep.
    Journal of veterinary pharmacology and therapeutics, 1991, Volume: 14, Issue:2

    Topics: Analgesia; Animals; Chronic Disease; Female; Foot Rot; Pain; Pain Measurement; Sensory Thresholds; S

1991
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
    Laboratory animal science, 1987, Volume: 37, Issue:6

    Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male;

1987
Antinociceptive activity and mechanism of action of detomidine.
    Journal of veterinary pharmacology and therapeutics, 1986, Volume: 9, Issue:3

    Topics: Acetates; Acetic Acid; Analgesics; Animals; Female; Imidazoles; Mice; Mice, Inbred Strains; Morphine

1986
Visceral analgesia: effects of xylazine, butorphanol, meperidine, and pentazocine in horses.
    American journal of veterinary research, 1985, Volume: 46, Issue:10

    Topics: Analgesia; Animals; Behavior, Animal; Butorphanol; Colic; Female; Heart; Horse Diseases; Horses; Mal

1985