ximelagatran has been researched along with Coronary-Artery-Disease* in 3 studies
2 review(s) available for ximelagatran and Coronary-Artery-Disease
| Article | Year |
|---|---|
Novel constructs for thrombin inhibition.
Topics: Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Azetidines; Benzylamines; Blood Coagulation; Coronary Artery Disease; Drug Design; Endothelium, Vascular; Factor Xa Inhibitors; Heparin; Humans; Naphthalenes; Polysaccharides; Prodrugs; Propionates; Stem Cell Transplantation; Thrombin; Thrombosis | 2005 |
The therapeutic potential of ximelagatran to become the anticoagulant of choice in medicine: a review of recently completed clinical trials.
Ximelagatran (Exanta, AstraZeneca) is a novel oral direct thrombin inhibitor that inhibits the final step in the coagulation process - namely, the conversion of fibrinogen to insoluble fibrin by thrombin. Recently completed large clinical trials have evaluated the efficacy and safety of ximelagatran compared to standard anticoagulation therapy with warfarin and heparins in several thrombotic disorders including the treatment and prevention of venous thromboembolism following major orthopaedic surgery; stroke prevention in atrial fibrillation; and after acute myocardial infarction. This article reviews these recent clinical trials and explores the therapeutic potential of ximelagatran to become the oral anticoagulant of first choice in medicine. Topics: Anticoagulants; Atrial Fibrillation; Azetidines; Benzylamines; Clinical Trials as Topic; Coronary Artery Disease; Drug Therapy, Combination; Glycine; Humans; Prodrugs; Stroke; Thrombin; Thromboembolism; Venous Thrombosis | 2004 |
1 other study(ies) available for ximelagatran and Coronary-Artery-Disease
| Article | Year |
|---|---|
Ximelagatran--promises and concerns.
Topics: Anticoagulants; Atrial Fibrillation; Azetidines; Benzylamines; Clinical Trials as Topic; Coronary Artery Disease; Humans; Prodrugs; Risk; Stroke; Venous Thrombosis | 2005 |