xestospongin-a and Carcinoma--Hepatocellular

xestospongin-a has been researched along with Carcinoma--Hepatocellular* in 1 studies

Other Studies

1 other study(ies) available for xestospongin-a and Carcinoma--Hepatocellular

Article	Year
Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology, 2006, Mar-15, Volume: 220, Issue:2-3 The effects of the organochlorine (OC) liver tumor promoter heptachlor epoxide (HE) and a related non-tumor promoting OC, delta-hexachlorocyclohexane (delta-HCH), on the dynamics of intracellular calcium (Ca2+) were investigated in mouse 1c1c7 hepatoma cells. HE induced a non-capacitative, Ca2+ entry-like phenomenon, which was transient and concentration-dependent with 10 and 50 microM HE. The plasma membrane Ca2+ channel blocker SKF-96365 antagonized this HE-induced Ca2+ entry. delta-HCH failed to induce Ca2+ entry, rather it antagonized the HE-induced Ca2+ entry. Both HE and delta-HCH induced Ca2+ release from endoplasmic reticulum (ER) at treatment concentrations as low as 10 microM; at 50 microM, the former induced 5x as much Ca2+ release as the latter. The HE-induced Ca2+ release from the ER was antagonized using the IP3 receptor/channel blocker xestospongin C, suggesting that HE induces ER Ca2+ release through the IP3 receptor/channel pore. These results show that the effect of HE on cellular Ca2+ mimics that of mitogens such as epidermal and hepatocyte growth factors. They also provide insight into the similarities and differences between tumorigenic and non-tumorigenic OCs, in terms of the mechanisms and the extent of the [Ca2+]i increased by these agents. Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carcinoma, Hepatocellular; Cell Line, Tumor; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression; Heptachlor Epoxide; Hexachlorocyclohexane; Imidazoles; Insecticides; Macrocyclic Compounds; Mice; Oxazoles; Transcription Factor AP-1	2006

Article

Year

Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells.

Toxicology, 2006, Mar-15, Volume: 220, Issue:2-3

The effects of the organochlorine (OC) liver tumor promoter heptachlor epoxide (HE) and a related non-tumor promoting OC, delta-hexachlorocyclohexane (delta-HCH), on the dynamics of intracellular calcium (Ca2+) were investigated in mouse 1c1c7 hepatoma cells. HE induced a non-capacitative, Ca2+ entry-like phenomenon, which was transient and concentration-dependent with 10 and 50 microM HE. The plasma membrane Ca2+ channel blocker SKF-96365 antagonized this HE-induced Ca2+ entry. delta-HCH failed to induce Ca2+ entry, rather it antagonized the HE-induced Ca2+ entry. Both HE and delta-HCH induced Ca2+ release from endoplasmic reticulum (ER) at treatment concentrations as low as 10 microM; at 50 microM, the former induced 5x as much Ca2+ release as the latter. The HE-induced Ca2+ release from the ER was antagonized using the IP3 receptor/channel blocker xestospongin C, suggesting that HE induces ER Ca2+ release through the IP3 receptor/channel pore. These results show that the effect of HE on cellular Ca2+ mimics that of mitogens such as epidermal and hepatocyte growth factors. They also provide insight into the similarities and differences between tumorigenic and non-tumorigenic OCs, in terms of the mechanisms and the extent of the [Ca2+]i increased by these agents.

Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carcinoma, Hepatocellular; Cell Line, Tumor; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression; Heptachlor Epoxide; Hexachlorocyclohexane; Imidazoles; Insecticides; Macrocyclic Compounds; Mice; Oxazoles; Transcription Factor AP-1

2006