xenon-129-atom and Lung-Neoplasms

Radiation-induced lung injury (RILI) is a common side effect in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy. Minimizing irradiation into highly functional areas of the lung may reduce the occurrence of RILI. The aim of this study is to evaluate the feasibility and utility of hyperpolarized xenon-129 magnetic resonance imaging (MRI), an imaging tool for evaluation of the pulmonary function, to guide radiotherapy planning.. Ten locally advanced NSCLC patients were recruited. Each patient underwent a simulation computed tomography (CT) scan and hyperpolarized xenon-129 MRI, then received 64 Gyin 32 fractions for radiotherapy. Clinical contours were drawn on CT. Lung regions with good ventilation were contoured based on the MRI. Two intensity-modulated radiation therapy plans were made for each patient: an anatomic plan (Plan-A) based on CT alone and a function-based plan (Plan-F) based on CT and MRI results. Compared to Plan-A, Plan-F was generated with two additional steps: (1) beam angles were carefully chosen to minimize direct radiation entering well-ventilated areas, and (2) additional optimization criteria were applied to well-ventilated areas to minimize dose exposure. V. Plan-A and Plan-F were both clinically acceptable and met similar target coverage and organ-at-risk constraints (p > 0.05) except for the ventilated lungs. Compared with Plan-A, V. In this pilot study, function-based radiotherapy planning using hyperpolarized xenon-129 MRI is demonstrated to be feasible in 10 patients with NSCLC with the potential to reduce radiation exposure in well-ventilated areas of the lung defined by hyperpolarized xenon-129 MRI.

Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Pilot Projects; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Xenon Isotopes

Hyperpolarized. Seven healthy subjects and six patients with pulmonary disorders were recruited to characterize. A 0.69 ms sinc was found to generate minimal off-resonance gas-phase excitation (3.0 ± 0.3% of the dissolved-phase), yielding a TE. Despite short dissolved-phase

Topics: Adult; Aged; Algorithms; alpha 1-Antitrypsin; Carcinoma, Non-Small-Cell Lung; Erythrocytes; Female; Gases; Heterozygote; Humans; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Lung Diseases; Lung Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Pulmonary Disease, Chronic Obstructive; Respiration; Solubility; Xenon Isotopes; Young Adult