xenon-129-atom and Cystic-Fibrosis

This paper systematically reviewed the literature reporting the validity and reliability of hyperpolarised gas MRI as a marker of lung health in cystic fibrosis (CF). MEDLINE, EMBASE and grey literature were searched for studies assessing the measurement properties of hyperpolarised helium-3 or xenon-129 MRI. The COSMIN risk of bias tool was used to critically appraise eligible studies. Findings show hyperpolarised gas MRI was able to detect structural and functional abnormalities in the lungs, detect response to treatments, and is more sensitive than FEV

Topics: Cystic Fibrosis; Helium; Humans; Isotopes; Magnetic Resonance Imaging; Reproducibility of Results; Xenon Isotopes

Conventional pulmonary function tests appear normal in early cystic fibrosis (CF) lung disease. Therefore, new diagnostic approaches are required that can detect CF lung disease in children and monitor treatment response. Hyperpolarized (HP) gas (

Topics: Adolescent; Child; Cystic Fibrosis; Disease Progression; Female; Helium; Humans; Isotopes; Magnetic Resonance Imaging; Male; Reproducibility of Results; Respiratory Function Tests; Workflow; Xenon Isotopes

3D Single-breath Chemical Shift Imaging (3D-SBCSI) is a hybrid MR-spectroscopic imaging modality that uses hyperpolarized xenon-129 gas (Xe-129) to differentiate lung diseases by probing functional characteristics. This study tests the efficacy of 3D-SBCSI in differentiating physiology among pulmonary diseases. A total of 45 subjects-16 healthy, 11 idiopathic pulmonary fibrosis (IPF), 13 cystic fibrosis (CF), and 5 chronic obstructive pulmonary disease (COPD)-were given 1/3 forced vital capacity (FVC) of hyperpolarized Xe-129, inhaled for a ~7 s MRI acquisition. Proton, Xe-129 ventilation, and 3D-SBCSI images were acquired with separate breath-holds using a radiofrequency chest coil tuned to Xe-129. The Xe-129 spectrum was analyzed in each lung voxel for ratios of spectroscopic peaks, chemical shifts, and T2* relaxation. CF and COPD subjects had significantly more ventilation defects than IPF and healthy subjects, which correlated with FEV1 predicted (R = -0.74). FEV1 predicted correlated well with RBC/Gas ratio (R = 0.67). COPD and IPF had significantly higher Tissue/RBC ratios than other subjects, longer RBC T2* relaxation times, and greater RBC chemical shifts. CF subjects had more ventilation defects than healthy subjects, elevated Tissue/RBC ratio, shorter Tissue T2* relaxation, and greater RBC chemical shift. 3D-SBCSI may be helpful in the detection and characterization of pulmonary disease, following treatment efficacy, and predicting disease outcomes.

Topics: Cystic Fibrosis; Gases; Humans; Idiopathic Pulmonary Fibrosis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Protons; Pulmonary Disease, Chronic Obstructive

Pulmonary magnetic resonance imaging using hyperpolarised

Topics: Adolescent; Child; Cystic Fibrosis; Female; Forced Expiratory Volume; Health Status Indicators; Humans; Linear Models; Lung; Magnetic Resonance Imaging; Male; Ontario; Prospective Studies; Pulmonary Ventilation; Respiratory Function Tests; Xenon Isotopes

The ventilation defect percent (VDP), measured from hyperpolarized (HP). This retrospective analysis included 26 participants from two institutions (18 CF, 8 healthy, age range 10-17). Pulmonary function tests, N. VDP measurements agreed for the two analysts with an intraclass correlation coefficient of 0.99. In the combined dataset, VDP measured by Analyst 1 was 5.96 ± 1.82% and 15.96 ± 6.76% for the healthy and CF groups, respectively (p = .0004). Analyst 2 showed similar differences between healthy and CF (p = .0003). VDP measured by either analyst was shown to correlate with FEV. HP

Topics: Adolescent; Child; Cystic Fibrosis; Female; Forced Expiratory Volume; Health Status Indicators; Humans; Lung; Magnetic Resonance Imaging; Male; Pulmonary Ventilation; Respiratory Function Tests; Retrospective Studies; Xenon Isotopes

Topics: Child; Cystic Fibrosis; Forced Expiratory Volume; Humans; Magnetic Resonance Imaging; Xenon Isotopes

Cystic fibrosis (CF) is a genetic disease which carries high morbidity and mortality from lung-function decline. Monitoring disease progression and treatment response in young patients is desirable, but serial imaging via CT is often considered prohibitive, and detailed functional information cannot be obtained using conventional imaging techniques. Hyperpolarized. 11 healthy controls (age 6-16years) and 11 patients with mild CF (age 8-16years, Forced Expiratory Volume (FEV. Hyperpolarized

Topics: Adolescent; Child; Cystic Fibrosis; Disease Progression; Female; Forced Expiratory Volume; Humans; Magnetic Resonance Imaging; Male; Predictive Value of Tests; Pulmonary Ventilation; Respiratory Function Tests; Sensitivity and Specificity; Xenon Isotopes

Topics: Adolescent; Breath Tests; Case-Control Studies; Child; Cystic Fibrosis; Female; Humans; Magnetic Resonance Imaging; Male; Respiratory Function Tests; Xenon Isotopes