The Journal of allergy and clinical immunology, 2021, Volume: 147, Issue:6
Measurement of regional lung ventilation with hyperpolarized. We hypothesized that. Thirty-seven children (13 with severe asthma, 8 with mild/moderate asthma, 16 age-matched healthy controls) aged 6 to 17 years old were imaged with. Children with asthma had higher VDP (P = .002) and number of defects per image slice (defects/slice) (P = .0001) than children without asthma. Children with clinically severe asthma had significantly higher VDP and number of defects/slice than healthy controls. Children with asthma who had a higher number of defects/slice had a higher rate of health care utilization (r = 0.48; P = .03) and oral corticosteroid use (r = 0.43; P = .05) at baseline. Receiver-operating characteristic analysis demonstrated that the VDP and number of defects/slice were predictive of increased health care utilization, asthma, and severe asthma. VDP correlated with FEV Topics: Adolescent; Asthma; Case-Control Studies; Child; Contrast Media; Female; Humans; Magnetic Resonance Imaging; Male; Respiratory Function Tests; ROC Curve; Severity of Illness Index; Xenon Isotopes | 2021 |