xanthine has been researched along with Status Epilepticus in 2 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors studied specific and sensitive indicators of neuronal adenosine triphosphate (ATP) depletion--hypoxanthine, xanthine and uridine levels--in the cerebrospinal fluid (CSF) of nine children during non-convulsive status epilepticus." | 3.67 | Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus. ( Brown, JK; Harkness, RA; Livingston, JH; McCreanor, GM, 1989) |
| "Their biomarker potential for seizures and epilepsy in peripheral blood has, however, not yet been investigated." | 1.62 | Elevated blood purine levels as a biomarker of seizures and epilepsy. ( Alves, M; Beamer, E; Conte, G; Dale, N; de Diego-Garcia, L; Delanty, N; El-Naggar, H; Engel, T; Henshall, DC; Khalil, M; Lacey, A; Rosenow, F; Tian, F, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beamer, E | 1 |
| Lacey, A | 1 |
| Alves, M | 1 |
| Conte, G | 1 |
| Tian, F | 1 |
| de Diego-Garcia, L | 1 |
| Khalil, M | 1 |
| Rosenow, F | 1 |
| Delanty, N | 1 |
| Dale, N | 1 |
| El-Naggar, H | 1 |
| Henshall, DC | 1 |
| Engel, T | 1 |
| Livingston, JH | 1 |
| Brown, JK | 1 |
| Harkness, RA | 1 |
| McCreanor, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for xanthine and Status Epilepticus
| Article | Year |
|---|---|
Elevated blood purine levels as a biomarker of seizures and epilepsy.
Topics: Adenosine; Adult; Animals; Biomarkers; Case-Control Studies; Epilepsy; Humans; Hypoxanthine; Inosine | 2021 |
Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus.
Topics: Child; Child, Preschool; Female; Humans; Hypoxanthine; Hypoxanthines; Hypoxia, Brain; Infant; Male; | 1989 |