xanthine has been researched along with Seizures in 5 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 7.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 3.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Their biomarker potential for seizures and epilepsy in peripheral blood has, however, not yet been investigated." | 1.62 | Elevated blood purine levels as a biomarker of seizures and epilepsy. ( Alves, M; Beamer, E; Conte, G; Dale, N; de Diego-Garcia, L; Delanty, N; El-Naggar, H; Engel, T; Henshall, DC; Khalil, M; Lacey, A; Rosenow, F; Tian, F, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beamer, E | 1 |
| Lacey, A | 1 |
| Alves, M | 1 |
| Conte, G | 1 |
| Tian, F | 1 |
| de Diego-Garcia, L | 1 |
| Khalil, M | 1 |
| Rosenow, F | 1 |
| Delanty, N | 1 |
| Dale, N | 1 |
| El-Naggar, H | 1 |
| Henshall, DC | 1 |
| Engel, T | 1 |
| MCCOLL, JD | 1 |
| PARKER, JM | 1 |
| FERGUSON, JK | 1 |
| Schmidt, H | 1 |
| Siems, WG | 1 |
| Grune, T | 1 |
| Grauel, EL | 1 |
| Sumi, S | 1 |
| Wada, Y | 1 |
| Berman, RF | 1 |
| Fredholm, BB | 1 |
| Aden, U | 1 |
| O'Connor, WT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for xanthine and Seizures
| Article | Year |
|---|---|
[Xanthine oxidase deficiency (hereditary xanthinuria), molybdenum cofactor deficiency].
Topics: Central Nervous System Diseases; Coenzymes; Diagnosis, Differential; Diet Therapy; Humans; Infant, N | 1996 |
4 other studies available for xanthine and Seizures
| Article | Year |
|---|---|
Elevated blood purine levels as a biomarker of seizures and epilepsy.
Topics: Adenosine; Adult; Animals; Biomarkers; Case-Control Studies; Epilepsy; Humans; Hypoxanthine; Inosine | 2021 |
A comparison of the relative toxic, emetic and convulsive actions of a series of methylated xanthine derivatives.
Topics: Emetics; Poisoning; Seizures; Theophylline; Vomiting; Xanthine; Xanthines | 1956 |
Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus.
Topics: Adenine; Bacterial Infections; Chromatography, High Pressure Liquid; Humans; Hydrocephalus; Hypoxant | 1995 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Model | 2000 |