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xanthine and Myocardial Ischemia

xanthine has been researched along with Myocardial Ischemia in 18 studies

7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.

Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Research Excerpts

ExcerptRelevanceReference
" The serum concentrations of hypoxanthine, xanthine, uric acid and allantoin were determined in peripheral blood samples from patients with angina pectoris, cerebral insult and myocardial infarction with thrombolytic therapy and were compared with the concentrations obtained for healthy males and females."7.69A comparative study of the concentrations of hypoxanthine, xanthine, uric acid and allantoin in the peripheral blood of normals and patients with acute myocardial infarction and other ischaemic diseases. ( Delvoux, B; Greiling, H; Kock, R; Sigmund, M, 1994)
") is thought to protect against the damaging effects of myocardial ischemia-reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage through the generation of reactive oxygen species."3.72Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. ( Ahluwalia, A; Benjamin, N; Bond, R; McLean, P; Uppal, R; Webb, A, 2004)
" The serum concentrations of hypoxanthine, xanthine, uric acid and allantoin were determined in peripheral blood samples from patients with angina pectoris, cerebral insult and myocardial infarction with thrombolytic therapy and were compared with the concentrations obtained for healthy males and females."3.69A comparative study of the concentrations of hypoxanthine, xanthine, uric acid and allantoin in the peripheral blood of normals and patients with acute myocardial infarction and other ischaemic diseases. ( Delvoux, B; Greiling, H; Kock, R; Sigmund, M, 1994)
"Hypoxanthine excretion was significantly elevated in patients compared with healthy controls (84."1.30Urinary hypoxanthine and xanthine levels in acute coronary syndromes. ( Bayindir, O; Boydak, B; Gülter, C; Habif, S; Mutaf, I; Ozmen, D; Senol, B; Turgan, N, 1999)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (66.67)18.2507
2000's4 (22.22)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, MC1
Velayutham, M1
Komatsu, T1
Hille, R1
Zweier, JL2
Lv, Y1
Liu, X2
Yan, S1
Liang, X1
Yang, Y1
Dai, W1
Zhang, W1
Bès, S1
Tatou, E1
Vandroux, D1
Tissier, C1
Rochette, L1
Athias, P1
Webb, A1
Bond, R1
McLean, P1
Uppal, R1
Benjamin, N1
Ahluwalia, A1
Li, H1
Cui, H1
Baldus, S1
Müllerleile, K1
Chumley, P1
Steven, D1
Rudolph, V1
Lund, GK1
Staude, HJ1
Stork, A1
Köster, R1
Kähler, J1
Weiss, C1
Münzel, T1
Meinertz, T1
Freeman, BA1
Heitzer, T1
Kukreja, RC1
Kontos, MC1
Loesser, KE1
Batra, SK1
Qian, YZ1
Gbur, CJ1
Naseem, SA1
Jesse, RL1
Hess, ML1
Elmoselhi, A1
Butcher, A1
Samson, SE1
Grover, AK1
Kock, R1
Delvoux, B1
Sigmund, M1
Greiling, H1
Golino, P1
Ragni, M1
Cirillo, P1
Avvedimento, VE1
Feliciello, A1
Esposito, N1
Scognamiglio, A1
Trimarco, B1
Iaccarino, G1
Condorelli, M1
Chiariello, M1
Ambrosio, G1
Schultz, HD1
Ustinova, EE1
Yeung, PK1
Buckley, SJ1
Hung, OR1
Pollak, PT1
Barclay, KD1
Feng, JD1
Klassen, GA1
Smolenski, RT2
Jayakumar, J1
Seymour, AM1
Yacoub, MH2
Zych, M1
Makarewicz, W1
Mei, DA1
Nithipatikom, K1
Lasley, RD1
Gross, GJ1
Turgan, N1
Boydak, B1
Habif, S1
Gülter, C1
Senol, B1
Mutaf, I1
Ozmen, D1
Bayindir, O1
Brunvand, H1
Westby, J1
Lekven, J1
Grong, K1
de Groot, MJ1
Coumans, WA1
van der Vusse, GJ1

Other Studies

18 other studies available for xanthine and Myocardial Ischemia

ArticleYear
Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
    Biochemistry, 2014, Oct-21, Volume: 53, Issue:41

    Topics: Animals; Animals, Inbred Strains; Avian Proteins; Biocatalysis; Cattle; Chickens; Dogs; Electron Spi

2014
Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2010, May-01, Volume: 52, Issue:1

    Topics: Allantoin; Animals; Biomarkers; Cardiovascular Agents; Chromatography, Liquid; Disease Models, Anima

2010
Physiological and metabolic actions of mycophenolate mofetil on cultured newborn rat cardiomyocytes in normoxia and in simulated ischemia.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:3

    Topics: Adenosine; Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Hypoxanthine; Immunosuppressive

2004
Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Sep-14, Volume: 101, Issue:37

    Topics: Animals; Cardiotonic Agents; Humans; Hydrogen-Ion Concentration; Male; Myocardial Ischemia; Myocardi

2004
Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation.
    The Journal of biological chemistry, 2005, Apr-29, Volume: 280, Issue:17

    Topics: Anions; Benzaldehydes; Binding Sites; Biotransformation; Catechols; Electrochemistry; Electrodes; El

2005
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy.
    Free radical biology & medicine, 2006, Oct-15, Volume: 41, Issue:8

    Topics: Aged; Cardiomyopathies; Cardiotonic Agents; Enzyme Inhibitors; Female; Humans; Hypoxanthine; Magneti

2006
Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart.
    The American journal of physiology, 1994, Volume: 267, Issue:6 Pt 2

    Topics: Animals; Coronary Circulation; Free Radicals; HSP70 Heat-Shock Proteins; Hydrogen Peroxide; In Vitro

1994
Coronary artery contractility, Na(+)-pump and oxygen radicals.
    General physiology and biophysics, 1994, Volume: 13, Issue:3

    Topics: Animals; Coronary Vessels; Hydrogen Peroxide; In Vitro Techniques; Kinetics; Muscle Contraction; Mus

1994
A comparative study of the concentrations of hypoxanthine, xanthine, uric acid and allantoin in the peripheral blood of normals and patients with acute myocardial infarction and other ischaemic diseases.
    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1994, Volume: 32, Issue:11

    Topics: Adult; Allantoin; Creatine Kinase; Female; Humans; Hypoxanthine; Hypoxanthines; Isoenzymes; Male; My

1994
Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion.
    Nature medicine, 1996, Volume: 2, Issue:1

    Topics: Animals; Blotting, Northern; Cells, Cultured; Coronary Circulation; Cycloheximide; Endothelium, Vasc

1996
Cardiac vagal afferent stimulation by free radicals during ischaemia and reperfusion.
    Clinical and experimental pharmacology & physiology, 1996, Volume: 23, Issue:8

    Topics: Animals; Capsaicin; Chemoreceptor Cells; Coronary Vessels; Heart; Hydrogen Peroxide; Myocardial Isch

1996
Effect of diltiazem on plasma concentrations of oxypurines and uric acid.
    Therapeutic drug monitoring, 1997, Volume: 19, Issue:3

    Topics: Adenosine; Adult; Cardiovascular Agents; Diltiazem; Female; Guanosine; Humans; Hypoxanthine; Inosine

1997
The effects of nucleotide pool on purine production in the postischemic heart.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Adenosine; Adenosine Triphosphate; Animals; Hypoxanthine; Inosine; Kinetics; Myocardial Ischemia; My

1998
Different mechanism of myocardial nucleotide breakdown during normothermic and hypothermic ischemia.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Adenosine; Animals; Heart Arrest, Induced; Hypoxanthine; In Vitro Techniques; Inosine; Myocardial Is

1998
Myocardial preconditioning produced by ischemia, hypoxia, and a KATP channel opener: effects on interstitial adenosine in dogs.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:6

    Topics: Adenine Nucleotides; Adenosine; Animals; Benzopyrans; Dihydropyridines; Dogs; Extracellular Space; H

1998
Urinary hypoxanthine and xanthine levels in acute coronary syndromes.
    International journal of clinical & laboratory research, 1999, Volume: 29, Issue:4

    Topics: Acute Disease; Adult; Aged; Angina, Unstable; Biomarkers; Blood Urea Nitrogen; Creatine; Female; Hum

1999
Myocardial adenine nucleotide depletion within 1 h of acute coronary artery occlusion.
    Scandinavian journal of clinical and laboratory investigation, 1992, Volume: 52, Issue:7

    Topics: Adenine Nucleotides; Animals; Cats; Constriction; Coronary Vessels; Energy Metabolism; Hemodynamics;

1992
The nucleotide metabolism in lactate perfused hearts under ischaemic and reperfused conditions.
    Molecular and cellular biochemistry, 1992, Dec-02, Volume: 118, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Animals; Energy Metabolism; Glucose; Glycogen; Guanosine Triphosp

1992