Page last updated: 2024-10-21

xanthine and Injury, Myocardial Reperfusion

xanthine has been researched along with Injury, Myocardial Reperfusion in 15 studies

7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.

Research Excerpts

ExcerptRelevanceReference
"By using a highly sensitive, high-performance liquid chromatographic technique, plasma values of malondialdehyde (MDA), adenosine and oxypurines were determined in 10 healthy subjects, 10 patients with noncardiac illness, and 20 patients with acute myocardial infarction (AMI) observed within 6 hours from the onset of symptoms."7.68Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction. ( Dagianti, A; Di Pierro, D; Fedele, F; Giardina, B; Lazzarino, G; Penco, M; Romano, S; Tavazzi, B, 1993)
") is thought to protect against the damaging effects of myocardial ischemia-reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage through the generation of reactive oxygen species."3.72Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. ( Ahluwalia, A; Benjamin, N; Bond, R; McLean, P; Uppal, R; Webb, A, 2004)
"By using a highly sensitive, high-performance liquid chromatographic technique, plasma values of malondialdehyde (MDA), adenosine and oxypurines were determined in 10 healthy subjects, 10 patients with noncardiac illness, and 20 patients with acute myocardial infarction (AMI) observed within 6 hours from the onset of symptoms."3.68Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction. ( Dagianti, A; Di Pierro, D; Fedele, F; Giardina, B; Lazzarino, G; Penco, M; Romano, S; Tavazzi, B, 1993)
"Xanthine produced an increase in the contractility of isolated perfused rabbit's heart."1.29Cardiac depressant effects of oxygen free radicals. ( Bharadwaj, L; Kalra, J; Prasad, K, 1993)
"Xanthine dehydrogenase was converted to xanthine oxidase during reperfusion and the activity of both enzymes were inhibited by allopurinol."1.28Purine and oxypurine production in mitochondria of ischemic and reperfused myocardium. ( Barnard, HC; Barnard, SP; Maartens, JJ; Potgieter, GM; van Jaarsveld, H, 1989)
"Hypoxanthine levels were fivefold more in Group 1 compared with Groups 2 and 3 (p less than 0."1.27Myocardial reperfusion injury. Role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury. ( Abd-Elfattah, AS; Brunsting, LA; Doherty, NE; Jessen, ME; Lekven, J; Wechsler, AS, 1988)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's10 (66.67)18.2507
2000's3 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maddika, S1
Elimban, V1
Chapman, D1
Dhalla, NS1
Webb, A1
Bond, R1
McLean, P1
Uppal, R1
Benjamin, N1
Ahluwalia, A1
Chahine, R1
Olivia, L1
Lockwell, H1
Nadeau, R1
Hudspeth, DA1
Williams, MW1
Zhao, ZQ1
Sato, H1
Nakanishi, K1
McGee, DS1
Hammon, JW1
Vinten-Johansen, J1
Van Wylen, DG1
Jacinto, SM1
Jandhyala, BS1
Giardina, B1
Penco, M1
Lazzarino, G1
Romano, S1
Tavazzi, B1
Fedele, F1
Di Pierro, D1
Dagianti, A1
Prasad, K1
Kalra, J1
Bharadwaj, L1
Yang, BC1
Nicolini, FA1
Nichols, WW1
Mehta, JL1
Martín-Jadraque, R1
Montero, C1
Mostaza, JM1
López-Sendón, JL1
Argomaniz, L1
Llorente, P1
Martín-Jadraque, L1
Mei, DA1
Gross, GJ1
Nithipatikom, K1
Obata, T1
Yamanaka, Y1
Durot, I1
Maupoil, V1
Ponsard, B1
Cordelet, C1
Vergely-Vandriesse, C1
Rochette, L1
Athias, P1
Bergsland, J1
Lobalsamo, L1
Lajos, PS1
Feldman, MJ1
Vanwylen, DG1
van Jaarsveld, H1
Barnard, HC1
Barnard, SP1
Maartens, JJ1
Potgieter, GM1
Abd-Elfattah, AS1
Jessen, ME1
Lekven, J1
Doherty, NE1
Brunsting, LA1
Wechsler, AS1

Other Studies

15 other studies available for xanthine and Injury, Myocardial Reperfusion

ArticleYear
Role of oxidative stress in ischemia-reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Calcium-Transporting ATPases; Cardiac Myosins; Catalase; Enzy

2009
Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Sep-14, Volume: 101, Issue:37

    Topics: Animals; Cardiotonic Agents; Humans; Hydrogen-Ion Concentration; Male; Myocardial Ischemia; Myocardi

2004
Oxygen-free radicals and myocardial nerve fibers endings.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1994, Volume: 46, Issue:4-5

    Topics: Animals; Electrolysis; Free Radicals; Heart; Immunohistochemistry; In Vitro Techniques; Male; Micros

1994
Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damaged hearts.
    The Annals of thoracic surgery, 1994, Volume: 58, Issue:3

    Topics: Adenosine; Animals; Creatine Kinase; Dogs; Heart Arrest, Induced; Hypoxanthine; Hypoxanthines; Inosi

1994
Depression of myocardial contractility is not a causative factor for circulatory deterioration in two experimental models of shock in anesthetized dogs.
    Annals of the New York Academy of Sciences, 1994, Jun-17, Volume: 723

    Topics: Animals; Dogs; Myocardial Contraction; Myocardial Reperfusion Injury; Reactive Oxygen Species; Shock

1994
Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction.
    The American journal of cardiology, 1993, Apr-01, Volume: 71, Issue:10

    Topics: Adenosine; Chromatography, High Pressure Liquid; Female; Free Radicals; Humans; Hypoxanthine; Hypoxa

1993
Cardiac depressant effects of oxygen free radicals.
    Angiology, 1993, Volume: 44, Issue:4

    Topics: Animals; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Female; Free Radical Scavenge

1993
Decreased endothelium-dependent vascular relaxation following subtotal coronary artery occlusion in dogs.
    Free radical biology & medicine, 1993, Volume: 14, Issue:3

    Topics: Acetylcholine; Animals; Coronary Artery Disease; Dogs; Endothelium, Vascular; Female; Free Radicals;

1993
[Urate production in a porcine model of myocardial ischemia-reperfusion].
    Revista espanola de cardiologia, 1996, Volume: 49, Issue:4

    Topics: Animals; Female; Free Radicals; Hypoxanthine; Hypoxanthines; Myocardial Reperfusion Injury; Myocardi

1996
Simultaneous determination of adenosine, inosine, hypoxanthine, xanthine, and uric acid in microdialysis samples using microbore column high-performance liquid chromatography with a diode array detector.
    Analytical biochemistry, 1996, Jun-15, Volume: 238, Issue:1

    Topics: Adenosine; Animals; Calibration; Chromatography, High Pressure Liquid; Dogs; Extracellular Space; Hy

1996
Protective effect of diltiazem on myocardial ischemic injury associated with .OH generation.
    Comparative biochemistry and physiology. Part A, Physiology, 1997, Volume: 117, Issue:2

    Topics: Allopurinol; Animals; Calcium Channel Blockers; Diltiazem; Heart Rate; Hydroxybenzoates; Hydroxyl Ra

1997
Oxidative injury of isolated cardiomyocytes: dependence on free radical species.
    Free radical biology & medicine, 2000, Nov-01, Volume: 29, Issue:9

    Topics: Action Potentials; Animals; Cells, Cultured; Electron Spin Resonance Spectroscopy; Fatty Acids; Free

2000
Oxypurinol protects normothermic ischemic hearts.
    Journal of cardiac surgery, 1990, Volume: 5, Issue:4

    Topics: Animals; Blood Pressure; Cardiac Output; Coronary Disease; Heart Arrest, Induced; Hypoxanthine; Hypo

1990
Purine and oxypurine production in mitochondria of ischemic and reperfused myocardium.
    Enzyme, 1989, Volume: 42, Issue:3

    Topics: Adenine Nucleotides; Adenosine; Allopurinol; Animals; Hypoxanthine; Hypoxanthines; Male; Malondialde

1989
Myocardial reperfusion injury. Role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury.
    Circulation, 1988, Volume: 78, Issue:5 Pt 2

    Topics: Adenine; Adenine Nucleotides; Animals; Coronary Disease; Dogs; Female; Free Radicals; Heart; Heart V

1988