xanthine has been researched along with Hypoxia-Ischemia, Brain in 4 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previously, we developed a pharmacokinetic-pharmacodynamic model of allopurinol, oxypurinol, and biomarkers, hypoxanthine, xanthine, and uric acid, in neonates with hypoxic-ischemic encephalopathy, in which high initial biomarker levels were observed suggesting an impact of hypoxia." | 4.12 | Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates. ( Allegaert, K; Chu, WY; Dorlo, TPC; Huitema, ADR, 2022) |
| " The dosage used and the effect of allopurinol in this population, either or not undergoing therapeutic hypothermia (TH), were evaluated." | 3.11 | Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates. ( Allegaert, K; Annink, KV; Bakkali, LE; Benders, MJNL; Chu, WY; Dorlo, TPC; Franz, AR; Hagen, A; Huitema, ADR; Maiwald, CA; Nijstad, AL; Schroth, M; van Bel, F; van Weissenbruch, MM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chu, WY | 2 |
| Annink, KV | 1 |
| Nijstad, AL | 1 |
| Maiwald, CA | 1 |
| Schroth, M | 1 |
| Bakkali, LE | 1 |
| van Bel, F | 1 |
| Benders, MJNL | 1 |
| van Weissenbruch, MM | 1 |
| Hagen, A | 1 |
| Franz, AR | 1 |
| Dorlo, TPC | 2 |
| Allegaert, K | 2 |
| Huitema, ADR | 2 |
| Bhatia, BD | 1 |
| Goel, A | 1 |
| Mink, R | 1 |
| Johnston, J | 1 |
2 trials available for xanthine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates.
Topics: Allopurinol; Biomarkers; Enzyme Inhibitors; Humans; Hypoxanthine; Hypoxia-Ischemia, Brain; Infant, N | 2022 |
Study of free radicals in neonates born through meconium stained amniotic fluid deliveries.
Topics: Amniotic Fluid; Asphyxia Neonatorum; Female; Free Radicals; Humans; Hypoxanthine; Hypoxia-Ischemia, | 2005 |
2 other studies available for xanthine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates.
Topics: Allopurinol; Clinical Studies as Topic; Humans; Hypoxanthine; Hypoxia; Hypoxia-Ischemia, Brain; Infa | 2022 |
The effect of infusing hypoxanthine or xanthine on hypoxic-ischemic brain injury in rabbits.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Enzyme Activators; Evoked Potentials, Somatosensory; | 2007 |