xanthine has been researched along with Disease Models, Animal in 23 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)." | 7.96 | Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020) |
| "In the present study we evaluate the possibility that xanthine oxidase released by damaged pancreas could act as a source of oxidative damage in systemic tissues during the early stages of acute pancreatitis." | 7.70 | Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure. ( Closa, D; Folch, E; Gelpí, E; Roselló-Catafau, J, 1998) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 7.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "In this study, we measured fetal plasma adenosine and xanthine concentrations during and after severe asphyxia, and investigated the key issues related to oxygen therapy." | 7.70 | Changes in fetal plasma adenosine and xanthine concentrations during fetal asphyxia with maternal oxygen administration in ewes. ( Araki, T; Murata, T; Power, GG; Sawa, R; Suzuki, S; Yoneyama, Y, 2000) |
| "Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)." | 3.96 | Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020) |
| "With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time." | 3.91 | A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity. ( Li, Q; Wang, F; Xing, C; Zhang, Y, 2019) |
| "In the present study we evaluate the possibility that xanthine oxidase released by damaged pancreas could act as a source of oxidative damage in systemic tissues during the early stages of acute pancreatitis." | 3.70 | Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure. ( Closa, D; Folch, E; Gelpí, E; Roselló-Catafau, J, 1998) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 3.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "In this study, we measured fetal plasma adenosine and xanthine concentrations during and after severe asphyxia, and investigated the key issues related to oxygen therapy." | 3.70 | Changes in fetal plasma adenosine and xanthine concentrations during fetal asphyxia with maternal oxygen administration in ewes. ( Araki, T; Murata, T; Power, GG; Sawa, R; Suzuki, S; Yoneyama, Y, 2000) |
| "Chagas disease affects 8 million people worldwide and remains a main cause of death due to heart failure in Latin America." | 1.42 | Lead identification to clinical candidate selection: drugs for Chagas disease. ( Arkin, M; Bryant, C; Chatterjee, AK; Chen, S; Gallardo-Godoy, A; Glynne, R; Gut, J; Kellar, D; Khare, S; McKerrow, J; Molteni, V; Neitz, RJ; Renslo, AR; Roach, SL; Robertson, S; Siqueira-Neto, JL; Stinson, M; Supek, F; Yeh, V, 2015) |
| " Next, we carried out a 7-day simultaneous treatment study by two daily treatments, that is, FYX-051 (6 mg/kg) and citrate (2,000 mg/kg), followed by citrate-alone treatment, under the conditions of selected dosing intervals, the second dose of citrate, and dosing volume." | 1.37 | Establishment of simultaneous treatment model with citrate for preventing nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats. ( Ashizawa, N; Matsumoto, K; Moto, M; Nagata, O; Shimo, T; Taniguchi, T, 2011) |
| "To test whether intermittent hypoxemia could, in part, explain this observed difference, Hx, xanthine (X), and uric acid were measured in vitreous humor, urine, plasma, and cerebrospinal fluid in newborn piglets during intermittent hypoxemia (IH) or continuous hypoxemia (CH) of equal degree and duration." | 1.29 | Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia. ( Oyasaeter, S; Rognum, TO; Rootwelt, T; Saugstad, OD; Stoltenberg, L, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, KQ | 1 |
| Li, YY | 1 |
| Wang, HL | 1 |
| Mao, XT | 1 |
| Guo, JX | 1 |
| Wang, F | 2 |
| Huang, LJ | 1 |
| Li, YN | 1 |
| Ma, XY | 1 |
| Gao, ZJ | 1 |
| Chen, W | 1 |
| Qian, DD | 1 |
| Xue, WJ | 1 |
| Cao, Q | 1 |
| Zhang, L | 2 |
| Shen, L | 1 |
| Tong, C | 1 |
| Zhong, JY | 1 |
| Lu, W | 1 |
| Lu, L | 1 |
| Ren, KM | 1 |
| Zhong, G | 1 |
| Wang, Y | 1 |
| Tang, M | 1 |
| Feng, XH | 1 |
| Chai, RJ | 1 |
| Jin, J | 1 |
| Sánchez-Melgar, A | 1 |
| Albasanz, JL | 1 |
| Pallàs, M | 1 |
| Martín, M | 1 |
| Zhang, Y | 1 |
| Li, Q | 1 |
| Xing, C | 1 |
| Neitz, RJ | 1 |
| Chen, S | 1 |
| Supek, F | 1 |
| Yeh, V | 1 |
| Kellar, D | 1 |
| Gut, J | 1 |
| Bryant, C | 1 |
| Gallardo-Godoy, A | 1 |
| Molteni, V | 1 |
| Roach, SL | 1 |
| Khare, S | 1 |
| Stinson, M | 1 |
| Chatterjee, AK | 1 |
| Robertson, S | 1 |
| Renslo, AR | 1 |
| Arkin, M | 1 |
| Glynne, R | 1 |
| McKerrow, J | 1 |
| Siqueira-Neto, JL | 1 |
| Jakubiczka-Smorag, J | 1 |
| Santamaria-Araujo, JA | 1 |
| Metz, I | 1 |
| Kumar, A | 1 |
| Hakroush, S | 1 |
| Brueck, W | 1 |
| Schwarz, G | 2 |
| Burfeind, P | 1 |
| Reiss, J | 2 |
| Smorag, L | 1 |
| Whidden, MA | 1 |
| McClung, JM | 1 |
| Falk, DJ | 1 |
| Hudson, MB | 1 |
| Smuder, AJ | 1 |
| Nelson, WB | 1 |
| Powers, SK | 1 |
| Ohtsubo, T | 1 |
| Matsumura, K | 1 |
| Sakagami, K | 1 |
| Fujii, K | 1 |
| Tsuruya, K | 1 |
| Noguchi, H | 1 |
| Rovira, II | 1 |
| Finkel, T | 1 |
| Iida, M | 1 |
| Lv, Y | 1 |
| Liu, X | 1 |
| Yan, S | 1 |
| Liang, X | 1 |
| Yang, Y | 1 |
| Dai, W | 1 |
| Zhang, W | 1 |
| Ashizawa, N | 1 |
| Shimo, T | 1 |
| Matsumoto, K | 1 |
| Taniguchi, T | 1 |
| Moto, M | 1 |
| Nagata, O | 1 |
| Salim, S | 1 |
| Asghar, M | 1 |
| Taneja, M | 1 |
| Hovatta, I | 1 |
| Chugh, G | 1 |
| Vollert, C | 1 |
| Vu, A | 1 |
| Lee, HJ | 1 |
| Adham, IM | 1 |
| Kneussel, M | 1 |
| Sass, JO | 1 |
| Engel, W | 1 |
| Jeong, HY | 2 |
| Kim, CD | 1 |
| Arimoto, T | 1 |
| Kadiiska, MB | 1 |
| Sato, K | 1 |
| Corbett, J | 1 |
| Mason, RP | 1 |
| Lim, KS | 1 |
| Huang, SH | 1 |
| Jenner, A | 1 |
| Wang, H | 1 |
| Tang, SY | 1 |
| Halliwell, B | 1 |
| Orengo, JM | 1 |
| Evans, JE | 1 |
| Bettiol, E | 1 |
| Leliwa-Sytek, A | 1 |
| Day, K | 1 |
| Rodriguez, A | 1 |
| Cai, M | 1 |
| Ogawa, R | 1 |
| Stoltenberg, L | 1 |
| Rootwelt, T | 1 |
| Oyasaeter, S | 1 |
| Rognum, TO | 1 |
| Saugstad, OD | 1 |
| Folch, E | 1 |
| Gelpí, E | 1 |
| Roselló-Catafau, J | 1 |
| Closa, D | 1 |
| Baudouin, C | 1 |
| Pisella, PJ | 1 |
| Ettaiche, M | 1 |
| Goldschild, M | 1 |
| Becquet, F | 1 |
| Gastaud, P | 1 |
| Droy-Lefaix, MT | 1 |
| Berman, RF | 1 |
| Fredholm, BB | 1 |
| Aden, U | 1 |
| O'Connor, WT | 1 |
| Loeffler, DA | 1 |
| Camp, DM | 1 |
| Juneau, PL | 1 |
| Harel, E | 1 |
| LeWitt, PA | 1 |
| Suzuki, S | 1 |
| Yoneyama, Y | 1 |
| Sawa, R | 1 |
| Murata, T | 1 |
| Araki, T | 1 |
| Power, GG | 1 |
| Akdemir, H | 1 |
| Aşik, Z | 1 |
| Paşaoğlu, H | 1 |
| Karaküçük, I | 1 |
| Oktem, IS | 1 |
| Koç, RK | 1 |
23 other studies available for xanthine and Disease Models, Animal
| Article | Year |
|---|---|
Stress-Induced Metabolic Disorder in Peripheral CD4
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain Diseases, Metabolic; CD4-Positive T-Lymphocytes; | 2019 |
Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
Topics: Adenosine; Aging; Alzheimer Disease; Animals; Cellular Senescence; Cerebral Cortex; Disease Models, | 2020 |
A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.
Topics: Allopurinol; Animals; Anserine; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughpu | 2019 |
Lead identification to clinical candidate selection: drugs for Chagas disease.
Topics: Animals; Cell Line; Chagas Disease; Colorimetry; Disease Models, Animal; Drug Discovery; Drug Evalua | 2015 |
Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.
Topics: Animals; Apoptosis; Carbon-Carbon Lyases; Coenzymes; Cysteine; Disease Models, Animal; Gene Expressi | 2016 |
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction.
Topics: Animals; Diaphragm; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Hypoxan | 2009 |
Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules.
Topics: Adipogenesis; Animals; Disease Models, Animal; Epithelial Cells; Female; Fibrosis; Glyceraldehyde-3- | 2009 |
Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Topics: Allantoin; Animals; Biomarkers; Cardiovascular Agents; Chromatography, Liquid; Disease Models, Anima | 2010 |
Establishment of simultaneous treatment model with citrate for preventing nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats.
Topics: Animals; Chelating Agents; Citric Acid; Disease Models, Animal; Enzyme Inhibitors; Kidney Diseases; | 2011 |
Potential contribution of oxidative stress and inflammation to anxiety and hypertension.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Buthionine Sulfoxi | 2011 |
Molybdenum cofactor-deficient mice resemble the phenotype of human patients.
Topics: Animals; Carbon-Carbon Lyases; Coenzymes; Disease Models, Animal; Humans; Metalloproteins; Mice; Mic | 2002 |
p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells.
Topics: Animals; Aorta; Base Sequence; Cell Division; Cells, Cultured; Diabetes Mellitus, Experimental; Dise | 2004 |
Synergistic production of lung free radicals by diesel exhaust particles and endotoxin.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Deferoxamine; Disease | 2005 |
Potential artifacts in the measurement of DNA deamination.
Topics: Amination; Animals; Artifacts; Cattle; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2006 |
Plasmodium-induced inflammation by uric acid.
Topics: Animals; Culture Media, Conditioned; Dendritic Cells; Disease Models, Animal; Erythrocytes; Hypoxant | 2008 |
Effects of free radical scavengers, methylprednisolone, and ulinastatin on acute xanthine and xanthine oxidase-induced lung injury in rats.
Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Glycoproteins; Infusions, Intravenous; Lun | 1994 |
Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Hypoxanthine; Hypoxanthines; Hypo | 1993 |
Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure.
Topics: Acute Disease; Analysis of Variance; Animals; Disease Models, Animal; Free Radicals; Lipid Peroxidat | 1998 |
Effects of EGb761 and superoxide dismutase in an experimental model of retinopathy generated by intravitreal production of superoxide anion radical.
Topics: Administration, Oral; Animals; Antioxidants; Disease Models, Animal; Electroretinography; Flavonoids | 1999 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Model | 2000 |
Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells.
Topics: Adenine; Adenosine; Animals; Disease Models, Animal; Dopamine; Guanine; Guanosine; Hypoxanthine; Neo | 2000 |
Changes in fetal plasma adenosine and xanthine concentrations during fetal asphyxia with maternal oxygen administration in ewes.
Topics: Adenosine; Animals; Asphyxia; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Female; Fe | 2000 |
The effect of allopurinol on focal cerebral ischaemia: an experimental study in rabbits.
Topics: Allopurinol; Animals; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Chromatography, High Pressu | 2001 |