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xanthine and Brain Ischemia

xanthine has been researched along with Brain Ischemia in 16 studies

7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
" Rats which survived hypoglycemia by insulin, hypoxia by 10% O2, or ischemia by carotid ligation and hypotension to 40 mm Hg, evidenced no changes in cerebrospinal fluid (CSF) uridine."7.68Opposite alterations in cerebrospinal fluid uridine after severe cerebral ischemia or intrathecal blood injection. ( Breese, GR; Hunt, RD; Lundberg, C; McCown, TJ; Mueller, RA, 1990)
"Global cerebral ischemia of 10 minutes duration was induced in newborn pigs anesthetized with isoflurane by occlusion of subclavian and brachiocephalic arteries; cortical cerebral blood flow (CBF) and interstitial adenosine concentration were evaluated simultaneously using the combined hydrogen clearance/microdialysis technique."5.29Effect of hypoglycemia on postischemic cortical blood flow, hypercapnic reactivity, and interstitial adenosine concentration. ( Gidday, JM; Gonzales, ER; Kim, YB; Park, TS; Shah, AR, 1994)
"Lactate accumulation, amino acid aspartate and glutamate levels, and hypoxanthine, xanthine and malondialdehyde (MDA) concentrations were compared in neonate rat brain after transient global hypoxia induced alone or in association with unilateral ligation of a carotid artery."3.70Changes in excitatory amino acid levels and tissue energy metabolites of neonate rat brain after hypoxia and hypoxia-ischemia. ( Barrier, L; Chalon, S; Guerraoui, A; Guilloteau, D; Huguet, F; Tallineau, C, 1998)
" Rats which survived hypoglycemia by insulin, hypoxia by 10% O2, or ischemia by carotid ligation and hypotension to 40 mm Hg, evidenced no changes in cerebrospinal fluid (CSF) uridine."3.68Opposite alterations in cerebrospinal fluid uridine after severe cerebral ischemia or intrathecal blood injection. ( Breese, GR; Hunt, RD; Lundberg, C; McCown, TJ; Mueller, RA, 1990)
"Cerebral blood flow (CBF, by laser Doppler flowmetry) and extracellular cortical concentrations (by microdialysis) of adenosine, inosine, xanthine, hypoxanthine, and lactate were measured together with somatosensory evoked potentials (SEP) in chloralose-anaesthetized spontaneously hypertensive rats (SHR) during relative cerebral ischemia induced by hypotensive hemorrhage."3.67Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites. ( Carlsson, S; Hagberg, H; Sandberg, M; Skarphedinsson, JO; Thorén, P, 1989)
"Cerebral hypoxanthine, xanthine, and uric acid levels were measured by high-performance liquid chromatography (HPLC) for up to 4 hours following focal cerebral ischemia in the rat."3.67[Early changes of oxypurines in rat brain following focal cerebral ischemia]. ( Nihei, H, 1988)
"In addition, it was found that global cerebral ischemia induced a statistically significant decrease of the hippocampal Na(+),K(+)-ATPase activity starting from 1 to 168 h of reperfusion."1.32Hyperbaric oxygen treatment: the influence on the hippocampal superoxide dismutase and Na+,K+-ATPase activities in global cerebral ischemia-exposed rats. ( Antoncić, I; Filipović, T; Mrsić-Pelcić, J; Pelcić, G; Simonić, A; Vitezić, D; Zupan, G, 2004)
"Global cerebral ischemia of 10 minutes duration was induced in newborn pigs anesthetized with isoflurane by occlusion of subclavian and brachiocephalic arteries; cortical cerebral blood flow (CBF) and interstitial adenosine concentration were evaluated simultaneously using the combined hydrogen clearance/microdialysis technique."1.29Effect of hypoglycemia on postischemic cortical blood flow, hypercapnic reactivity, and interstitial adenosine concentration. ( Gidday, JM; Gonzales, ER; Kim, YB; Park, TS; Shah, AR, 1994)
"Adenosine, which also increases during cerebral ischemia, is proposed to inhibit neurotransmitter release."1.28Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia. ( Grabb, MC; Roche, FM; Sciotti, VM; Van Wylen, DG, 1992)
"Xanthine oxidase was assayed by high pressure liquid chromatography using ultraviolet and electrochemical detection."1.28Ischaemic brain oedema and xanthine-xanthine oxidase system. ( Ishikawa, M; Kikuchi, H; Kinuta, Y, 1990)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's8 (50.00)18.2507
2000's3 (18.75)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mrsić-Pelcić, J1
Pelcić, G1
Vitezić, D1
Antoncić, I1
Filipović, T1
Simonić, A1
Zupan, G1
Levin, SD1
Brown, JK1
Harkness, RA1
Kim, YB1
Gidday, JM1
Gonzales, ER1
Shah, AR1
Park, TS1
Kuracka, L1
Kalnovicová, T1
Líska, B1
Turcáni, P1
Huguet, F1
Guerraoui, A1
Barrier, L1
Guilloteau, D1
Tallineau, C1
Chalon, S1
Satoh, T1
Ishikawa, Y1
Kataoka, Y1
Cui, Y1
Yanase, H1
Kato, K1
Watanabe, Y2
Nakadate, K1
Matsumura, K1
Hatanaka, H1
Kataoka, K1
Noyori, R1
Suzuki, M1
Prough, DS1
Bedell, EA1
Akdemir, H1
Aşik, Z1
Paşaoğlu, H1
Karaküçük, I1
Oktem, IS1
Koç, RK1
Sciotti, VM1
Roche, FM1
Grabb, MC1
Van Wylen, DG1
Pellegrini-Giampietro, DE1
Cherici, G1
Alesiani, M1
Carla, V1
Moroni, F1
Kinuta, Y1
Kikuchi, H1
Ishikawa, M1
Mueller, RA1
McCown, TJ1
Hunt, RD1
Lundberg, C1
Breese, GR1
Skarphedinsson, JO1
Sandberg, M2
Hagberg, H2
Carlsson, S1
Thorén, P1
Andersson, P1
Butcher, S1
Lehmann, A1
Hamberger, A1
Nihei, H1
Betz, AL1

Reviews

1 review available for xanthine and Brain Ischemia

ArticleYear
Cerebral ischemia in humans after traumatic brain injury.
    Critical care medicine, 2001, Volume: 29, Issue:2

    Topics: Adenosine; Brain Chemistry; Brain Injuries; Brain Ischemia; Extracellular Space; Humans; Jugular Vei

2001

Other Studies

15 other studies available for xanthine and Brain Ischemia

ArticleYear
Hyperbaric oxygen treatment: the influence on the hippocampal superoxide dismutase and Na+,K+-ATPase activities in global cerebral ischemia-exposed rats.
    Neurochemistry international, 2004, Volume: 44, Issue:8

    Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Hippocampus; Hyperbaric Oxygenation; Rats; Rats, Wi

2004
Cerebrospinal fluid hypoxanthine and xanthine concentrations as indicators of metabolic damage due to raised intracranial pressure in hydrocephalic children.
    Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:7

    Topics: Adolescent; Brain Diseases, Metabolic; Brain Ischemia; Child; Child, Preschool; Energy Metabolism; H

1984
Effect of hypoglycemia on postischemic cortical blood flow, hypercapnic reactivity, and interstitial adenosine concentration.
    Journal of neurosurgery, 1994, Volume: 81, Issue:6

    Topics: Adenosine; Animals; Animals, Newborn; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Corte

1994
HPLC method for measurement of purine nucleotide degradation products in cerebrospinal fluid.
    Clinical chemistry, 1996, Volume: 42, Issue:5

    Topics: Adult; Brain Ischemia; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hyp

1996
Changes in excitatory amino acid levels and tissue energy metabolites of neonate rat brain after hypoxia and hypoxia-ischemia.
    Neuroscience letters, 1998, Jan-09, Volume: 240, Issue:2

    Topics: Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Ischemia; Energy Metabolism; Excitatory Amino

1998
CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain.
    The European journal of neuroscience, 1999, Volume: 11, Issue:9

    Topics: Animals; Autoradiography; Brain Ischemia; Cell Death; Cell Survival; Central Nervous System; Epopros

1999
The effect of allopurinol on focal cerebral ischaemia: an experimental study in rabbits.
    Neurosurgical review, 2001, Volume: 24, Issue:2-3

    Topics: Allopurinol; Animals; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Chromatography, High Pressu

2001
Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:4

    Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Glutamates; Glutamic Acid; Hypo

1992
Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:3

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Free Radicals; Glutamates; Glutamic Acid; Male;

1990
Ischaemic brain oedema and xanthine-xanthine oxidase system.
    Acta neurochirurgica. Supplementum, 1990, Volume: 51

    Topics: Animals; Brain Edema; Brain Ischemia; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred

1990
Opposite alterations in cerebrospinal fluid uridine after severe cerebral ischemia or intrathecal blood injection.
    Cellular and molecular neurobiology, 1990, Volume: 10, Issue:3

    Topics: Animals; Blood; Brain Ischemia; Heart Arrest; Hypoglycemia; Hypoxanthine; Hypoxanthines; Hypoxia; In

1990
Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1989, Volume: 9, Issue:3

    Topics: Adenosine; Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Circulation; Extrace

1989
Blockade of N-methyl-D-aspartate-sensitive acidic amino acid receptors inhibits ischemia-induced accumulation of purine catabolites in the rat striatum.
    Neuroscience letters, 1986, Aug-04, Volume: 68, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Brain Ischemia; Corpus Striatum; Hypoxanthine; Hypo

1986
[Early changes of oxypurines in rat brain following focal cerebral ischemia].
    No to shinkei = Brain and nerve, 1988, Volume: 40, Issue:8

    Topics: Animals; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Hypoxanthine; Hypoxanthines; M

1988
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries.
    Journal of neurochemistry, 1985, Volume: 44, Issue:2

    Topics: Adenine; Allopurinol; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Cap

1985