Compounds > wr 99210
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wr 99210 and Infections, Plasmodium

wr 99210 has been researched along with Infections, Plasmodium in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's1 (11.11)18.2507
2000's2 (22.22)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Genther, CS; Smith, CS1
Ager, AL; Bliss, RA; Canfield, CJ; Jacobus, DP; Jensen, NP; Kotecka, BM; Rieckmann, KH; Terpinski, J1
Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B1
Adane, L; Arfeen, M; Bhagat, S; Bharatam, PV; Chakraborti, AK; Singh, PP; Singh, S1
Hastings, MD; Sibley, CH1
Howells, RE; Judge, BM1
Knight, DJ; Mamalis, P; Peters, W1
Knight, DJ; Williamson, P1
Corcoran, KD; Edstein, MD; Hansukjariya, P; Ngampochjana, M; Rieckmann, KH; Sattabongkot, J; Shanks, GD; Webster, HK1

Other Studies

9 other study(ies) available for wr 99210 and Infections, Plasmodium

ArticleYear
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:2

    Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Malaria; Mice; Plasmodium berghei; Triazines

1977
Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.
    Journal of medicinal chemistry, 2001, Nov-08, Volume: 44, Issue:23

    Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Guanidines; Malaria; Male; Mice; Plasmodium berghei; Plasmodium falciparum; Prodrugs; Proguanil; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines

2001
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase

2010
Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies.
    European journal of medicinal chemistry, 2017, Jul-28, Volume: 135

    Topics: Antimalarials; Dose-Response Relationship, Drug; Guanylthiourea; Malaria; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship

2017
Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Oct-01, Volume: 99, Issue:20

    Topics: Alleles; Amino Acid Sequence; Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Inhibitory Concentration 50; Malaria; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Plasmodium vivax; Point Mutation; Proguanil; Pyrimethamine; Recombinant Proteins; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Triazines

2002
Sustained-release implants in the chemotherapy of experimental rodent malaria I. A comparison of the effects of some antimalarials in polydimethylsiloxane matrices.
    Annals of tropical medicine and parasitology, 1981, Volume: 75, Issue:5

    Topics: Animals; Antimalarials; Chloroquine; Dimethylpolysiloxanes; Drug Implants; Malaria; Male; Mefloquine; Mice; Mice, Inbred Strains; Naphthoquinones; Piperidines; Plasmodium berghei; Primaquine; Proguanil; Pyrimethamine; Quinolines; Silicone Elastomers; Sulfadiazine; Triazines

1981
The antimalarial activity of N-benzyl-oxydihydrotriazines. III. The activity of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5,-trichloropropyloxy)-1,3,5-triazine hydrobromide (BRL 51084) and hydrochloride (BRL 6231).
    Annals of tropical medicine and parasitology, 1982, Volume: 76, Issue:1

    Topics: Animals; Antimalarials; Drug Resistance; Macaca mulatta; Malaria; Male; Mice; Plasmodium berghei; Triazines

1982
The antimalarial activity of N-benzyl-oxydihydrotriazines. IV. The development of resistance to BRL 6231 (4,6-diamino-1,2-dihyydro-2-,2-dimethyl-1-(2,4,5-trichloropropyloxy)-1,3,5 triazine hydrochloride) by Plasmodium berghei.
    Annals of tropical medicine and parasitology, 1982, Volume: 76, Issue:1

    Topics: Animals; Antimalarials; Drug Resistance; Malaria; Male; Mice; Plasmodium berghei; Pyrimethamine; Triazines

1982
Evaluation of WR250417 (a proguanil analog) for causal prophylactic activity in the Plasmodium cynomolgi-Macaca mulatta model.
    The American journal of tropical medicine and hygiene, 1994, Volume: 50, Issue:2

    Topics: Administration, Oral; Animals; Antimalarials; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Half-Life; Macaca mulatta; Malaria; Male; Plasmodium cynomolgi; Proguanil; Triazines

1994