Compounds > wr 1065
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wr 1065 and Breast Cancer

wr 1065 has been researched along with Breast Cancer in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhoumik, A; Dimas, K; Hainaut, P; North, S; Pluquet, O; Ronai, Z1
Aickin, M; Alberts, DS; Barrett, A; Capizzi, RL; Conlon, J; Krutzsch, M; Speicher, LA; Wymer, J1
Chen, ZJ; Hopper, E; Murphy, M; Shen, H; Tew, KD; Zilfou, JT1

Other Studies

3 other study(ies) available for wr 1065 and Breast Cancer

ArticleYear
The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
    The Journal of biological chemistry, 2003, Apr-04, Volume: 278, Issue:14

    Topics: 3T3 Cells; Animals; Breast Neoplasms; DNA Damage; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mercaptoethylamines; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Radiation-Protective Agents; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2003
WR-1065, the active metabolite of amifostine (Ethyol), does not inhibit the cytotoxic effects of a broad range of standard anticancer drugs against human ovarian and breast cancer cells.
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A Suppl 4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Mercaptoethylamines; Ovarian Neoplasms; Tumor Cells, Cultured

1996
Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytoprotection; Electrophoresis, Polyacrylamide Gel; Fibroblasts; HeLa Cells; Humans; Melanoma; Mercaptoethylamines; Mice; NF-kappa B; NF-kappa B p50 Subunit; Nuclear Proteins; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-mdm2; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation; Tumor Suppressor Protein p53

2001