wp1066 has been researched along with Carcinoma--Hepatocellular* in 1 studies
1 other study(ies) available for wp1066 and Carcinoma--Hepatocellular
Article | Year |
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Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells.
Signal transducer and activator of transcription 3 (STAT3) is a tumorigenic transcription factor that is persistently activated in various human cancers including hepatocellular carcinoma (HCC). Therefore, STAT3 is considered as a prominent target to counteract the uncontrolled proliferation of cancer cells. In the present report, pyrimidine-2,4-diones (N-methyluracil derivatives) (MNK1-MNK14) were synthesized in an ionic liquid (BMIm PF Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Signal Transduction; STAT3 Transcription Factor | 2021 |