wogonoside and Colitis--Ulcerative

wogonoside has been researched along with Colitis--Ulcerative* in 1 studies

Other Studies

1 other study(ies) available for wogonoside and Colitis--Ulcerative

Article	Year
Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway. Acta pharmacologica Sinica, 2020, Volume: 41, Issue:6 Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin, which has shown various pharmacological activities including anti-inflammatory, antitumor, antioxidant, etc. Thus far, the effect of oroxindin on colonic inflammation and the underlying mechanism remain unknown. In this study, we investigated the tissue distribution of oroxindin and its therapeutic effects on ulcerative colitis (UC) as well as the underlying mechanisms. UC model was established in mice by administrating dextran sulfate sodium (DSS) in drinking water for 7 d. We first showed that oroxindin was largely absorbed by the colon as an active ingredient after normal mice received Huang-Qin-Tang, a traditional Chinese medicine decoction. UC mice were then treated with oroxindin (12.5, 25, 50 mg ·kg Topics: Administration, Oral; Animals; Carrier Proteins; Chromones; Colitis, Ulcerative; Dextran Sulfate; Dose-Response Relationship, Drug; Glucuronates; Inflammasomes; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Structure-Activity Relationship; Thioredoxins	2020

Article

Year

Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway.

Acta pharmacologica Sinica, 2020, Volume: 41, Issue:6

Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin, which has shown various pharmacological activities including anti-inflammatory, antitumor, antioxidant, etc. Thus far, the effect of oroxindin on colonic inflammation and the underlying mechanism remain unknown. In this study, we investigated the tissue distribution of oroxindin and its therapeutic effects on ulcerative colitis (UC) as well as the underlying mechanisms. UC model was established in mice by administrating dextran sulfate sodium (DSS) in drinking water for 7 d. We first showed that oroxindin was largely absorbed by the colon as an active ingredient after normal mice received Huang-Qin-Tang, a traditional Chinese medicine decoction. UC mice were then treated with oroxindin (12.5, 25, 50 mg ·kg

Topics: Administration, Oral; Animals; Carrier Proteins; Chromones; Colitis, Ulcerative; Dextran Sulfate; Dose-Response Relationship, Drug; Glucuronates; Inflammasomes; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Structure-Activity Relationship; Thioredoxins

2020