wogonin has been researched along with Leukemia--Lymphocytic--Chronic--B-Cell* in 1 studies
1 other study(ies) available for wogonin and Leukemia--Lymphocytic--Chronic--B-Cell
| Article | Year |
|---|---|
Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.
Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247 chronic lymphocytic leukemia serum samples revealed elevated levels of tumor necrosis factor (TNF) receptor-1 which were associated with poor clinical outcome. We detected a microenvironment-induced expression of TNF receptor-1 in chronic lymphocytic leukemia cells Topics: Adoptive Transfer; Animals; Coculture Techniques; Flavanones; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Mice; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Cells, Cultured; Tumor Microenvironment | 2018 |