wogonin has been researched along with Inflammatory-Bowel-Diseases* in 1 studies
1 other study(ies) available for wogonin and Inflammatory-Bowel-Diseases
| Article | Year |
|---|---|
Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease
Increasing the anti-inflammatory cytokine interleukin-10 (IL-10) level is a promising strategy to suppress the progression of pathogenic inflammation including inflammatory bowel disease (IBD). Since cyclin-dependent kinase 8 (CDK8) inhibition can upregulate IL-10 abundance in activated myeloid-derived dendritic cells, it is considered to be an effective target for IBD treatment. Here, the complete discovery process of a novel CDK8 inhibitor as an anti-inflammatory agent was described. Starting with wogonin, structure-based optimization and structure-activity relationship (SAR) study were comprehensively carried out, and then lead compound Topics: Animals; Anti-Inflammatory Agents; Cyclin-Dependent Kinase 8; Inflammatory Bowel Diseases; Interleukin-10; Molecular Structure; Protein Kinase Inhibitors; Up-Regulation | 2022 |