withaferin-a has been researched along with Sarcoma-180* in 3 studies
1 review(s) available for withaferin-a and Sarcoma-180
| Article | Year |
|---|---|
Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization.
Study of antitumor and radiosensitizing properties of W. somnifera (Ashwagandha), a well known medicinal plant, have yielded encouraging results. The alcoholic extract of the dried roots of the plant as well as the active component withaferin A isolated from the extract showed significant antitumor and radiosensitizing effects in experimental tumors in vivo, without any noticeable systemic toxicity. Withaferin A gave a sensitizer enhancement ratio of 1.5 for in vitro cell killing of V79 Chinese hamster cells at a non toxic concentration of approximately 2 microM. The mechanism of action of this compound is not known. The studies so far indicate that W. somnifera could prove to be a good natural source of a potent and relatively safe radiosensitizer/chemotherapeutic agent. Further studies are needed to explore the clinical potential of this plant for cancer therapy. Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cricetinae; Ergosterol; Humans; Medicine, Ayurvedic; Mice; Plants, Medicinal; Radiation-Sensitizing Agents; Sarcoma 180; Withanolides | 1996 |
2 other study(ies) available for withaferin-a and Sarcoma-180
| Article | Year |
|---|---|
The effect of withaferin A, a natural steroidal lactone, on the fine structure of S-180 tumor cells.
Mouse sarcoma 180 (S-180) solid and ascites tumor cells were treated in vivo and in vitro with withaferin A and observed with the electron microscope. The compound was found to effect this spindle microtubules of cells in metaphase. An interesting finding was the double membranes surrounding the chromosomes in the treated cells; probably the nuclei were reconstructed directly from the metaphase stage in the in vivo withaferin A-treated cells. In addition the membranes of the cells in interphase were affected by in vivo or in vitro treatment with the compound. Topics: Animals; Cell Nucleus; Cholestenes; Cholestenones; Chromosomes; In Vitro Techniques; Lactones; Membranes; Mice; Mice, Inbred DBA; Microtubules; Mitosis; Sarcoma 180; Withanolides | 1976 |
Mode of action of Withaferin A and Withanolide D.
Topics: Animals; Antineoplastic Agents; Cholestenes; Cholestenones; Depression, Chemical; Ethers, Cyclic; Lactones; Male; Mice; Neoplasm Transplantation; Phenylalanine; RNA, Neoplasm; Sarcoma 180; Transplantation, Homologous; Uracil; Withanolides | 1975 |