wedelolactone has been researched along with Body-Weight* in 1 studies
1 other study(ies) available for wedelolactone and Body-Weight
| Article | Year |
|---|---|
Evaluation of neuroprotective effects of wedelolactone and gallic acid on aluminium-induced neurodegeneration: Relevance to sporadic amyotrophic lateral sclerosis.
Al exposure causes an alteration in the several ions in the body and causes toxicity. Such as apoptosis, oxidative stress, disruption in neuronal transport, mitochondrial damage, excitotoxicity, generation of inflammatory mediators, and microglial activation. These multiple mechanisms lead to the several neurodegenerative diseases, including sporadic amyotrophic lateral sclerosis (sALS). The study aims to unravel the mechanisms behind the neuroprotective effects of wedelolactone (WL) and gallic acid (GA) against aluminium-induced neurodegeneration and thereby to unlock a platform to find a cure for sALS. We studied the neuroprotective effects of WL (100 & 200 mg/kg) and GA (100 & 200 mg/kg) using aluminium chloride (AlCl Topics: Aluminum; Amyotrophic Lateral Sclerosis; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Caspase 3; Coumarins; Female; Gallic Acid; Gene Expression Regulation; Glutamic Acid; Interleukin-6; Male; Mice; Neuroprotective Agents; Rats; Rotarod Performance Test; Tumor Necrosis Factor-alpha | 2018 |