wb 4101 has been researched along with Narcolepsy in 1 studies
N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experiments have shown that prazosin, an alpha 1 antagonist, dramatically aggravates canine narcolepsy-cataplexy through a central mechanism, and that [3H]prazosin binding sites are increased in the amygdala of narcoleptic dogs." | 3.67 | Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep. ( Bowersox, S; Ciaranello, R; Dement, WC; Frusthofer, B; Guilleminault, C; Maddaluno, J; Mignot, E; Nishino, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mignot, E | 1 |
| Guilleminault, C | 1 |
| Bowersox, S | 1 |
| Frusthofer, B | 1 |
| Nishino, S | 1 |
| Maddaluno, J | 1 |
| Ciaranello, R | 1 |
| Dement, WC | 1 |
1 other study available for wb 4101 and Narcolepsy
| Article | Year |
|---|---|
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cataplexy; Clonidine; Dioxanes; Dogs; Narcolepsy; Phen | 1989 |