wb 4101 has been researched along with Myocardial Ischemia in 6 studies
N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is concluded that automatic arrhythmias induced by alpha 1-adrenergic stimulation during simulated ischemia may be attributed to a specific alpha 1-adrenergic receptor subtype that is blocked by WB-4101." | 1.29 | [The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers]. ( Aniukhovskiĭ, EP; Rosen, MR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Billman, GE | 1 |
| Aniukhovskiĭ, EP | 2 |
| Rosen, MR | 4 |
| Anyukhovsky, EP | 2 |
| Steinberg, SF | 1 |
| Cohen, IS | 1 |
| Geller, JC | 1 |
| Cua, M | 1 |
| Prieto, L | 1 |
| Guo, SD | 2 |
| Danilo, P | 2 |
| Rozen, MP | 1 |
| Staĭnberg, SF | 1 |
6 other studies available for wb 4101 and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of alpha 1-adrenergic receptor antagonists on susceptibility to malignant arrhythmias: protection from ventricular fibrillation.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Disease Models, Animal; Dogs; Elect | 1994 |
[The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers].
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Arrhythmias, Cardiac | 1993 |
Receptor-effector coupling pathway for alpha 1-adrenergic modulation of abnormal automaticity in 'ischemic' canine Purkinje fibers.
Topics: Adrenergic alpha-Antagonists; Animals; Barium; Clonidine; Dioxanes; Dogs; Membrane Potentials; Myoca | 1994 |
Chloroethylclonidine increases the incidence of lethal arrhythmias during coronary occlusion in anesthetized dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Female; Male | 1995 |
Responses to norepinephrine of normal and "ischemic" canine Purkinje fibers are consistent with activation of different alpha 1-receptor subtypes.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aminoquinolines; Animals | 1997 |
[Modulation of heart rhythm by alpha-1 adrenoreceptors].
Topics: Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Electrocardiography; Heart Rate; Myocardia | 1992 |