wb 4101 has been researched along with Muscle Contraction in 61 studies
N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Clonidine (alpha 2 agonist) did not enhance ACh release or nerve-stimulated muscle contractions, while phenylephrine (alpha 1 agonist) and norepinephrine increased muscle contractions up to 19." | 3.66 | Noradrenergic-mediated potentiation of acetylcholine release from the phrenic nerve: evidence for presynaptic alpha 1-adrenoceptor involvement. ( Gerald, MC; Snider, RM, 1982) |
| " Dose-response curves were obtained sequentially with a wash-out of 20 min between each concentration; the maximum contractility of an individual muscle ring was set at 100%." | 1.32 | Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction. ( Eckert, RE; Karsten, AJ, 2004) |
| "Pretreatment with chlorethylclonidine (CEC) at concentrations ranging from 0." | 1.29 | Pharmacological evidence of distinct alpha 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery. ( Hatano, A; Koizumi, T; Komeyama, T; Takahashi, H; Takeda, M; Tamaki, M, 1994) |
| "WB 4101 was found to be equally effective in antagonizing noradrenaline on all arteries." | 1.28 | Vascular alpha-adrenoceptor affinity variation is not due to varying populations of subtypes distinguished by WB 4101 and chlorethylclonidine. ( Bevan, JA; Bevan, RD; Oriowo, MA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (19.67) | 18.7374 |
| 1990's | 39 (63.93) | 18.2507 |
| 2000's | 10 (16.39) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nelson, WL | 1 |
| Powell, ML | 1 |
| Dyer, DC | 2 |
| Pigini, M | 4 |
| Brasili, L | 4 |
| Giannella, M | 3 |
| Giardinà, D | 4 |
| Gulini, U | 2 |
| Quaglia, W | 3 |
| Melchiorre, C | 7 |
| Tayebati, SK | 1 |
| Piergentili, A | 2 |
| Marucci, G | 4 |
| Bolognesi, ML | 2 |
| Budriesi, R | 1 |
| Cavalli, A | 2 |
| Chiarini, A | 1 |
| Gotti, R | 1 |
| Leonardi, A | 4 |
| Minarini, A | 2 |
| Poggesi, E | 4 |
| Recanatini, M | 1 |
| Rosini, M | 2 |
| Tumiatti, V | 1 |
| Gentili, F | 1 |
| Carrieri, A | 1 |
| Carotti, A | 1 |
| Sorbi, C | 1 |
| Franchini, S | 1 |
| Manicardi, M | 1 |
| Angeli, P | 1 |
| Antonello, A | 1 |
| Han, JL | 1 |
| Zhang, YY | 1 |
| Lü, ZZ | 1 |
| Mao, JM | 1 |
| Chen, MZ | 1 |
| Han, QD | 1 |
| Campos, M | 1 |
| Morais, Pde L | 1 |
| Pupo, AS | 2 |
| Chou, EC | 1 |
| Capello, SA | 1 |
| Levin, RM | 1 |
| Longhurst, PA | 1 |
| Karsten, AJ | 2 |
| Eckert, RE | 2 |
| Gray, KT | 1 |
| Ventura, S | 2 |
| Jurkiewicz, NH | 2 |
| Caricati-Neto, A | 2 |
| Verde, LF | 1 |
| Avellar, MC | 2 |
| Reuter, HR | 1 |
| Jurkiewicz, A | 3 |
| Gallucci, P | 2 |
| Takeyasu, K | 1 |
| Higuchi, H | 1 |
| Uchida, S | 1 |
| Matsumoto, K | 1 |
| Fujita, N | 1 |
| Yoshida, H | 1 |
| Snider, RM | 1 |
| Gerald, MC | 1 |
| Mottram, DR | 4 |
| Castagnino, E | 1 |
| Strappaghetti, G | 1 |
| Corsano, S | 1 |
| Chapple, CR | 1 |
| Burt, RP | 1 |
| Andersson, PO | 1 |
| Greengrass, P | 1 |
| Wyllie, M | 1 |
| Marshall, I | 1 |
| Muramatsu, I | 3 |
| Oshita, M | 2 |
| Ohmura, T | 3 |
| Kigoshi, S | 1 |
| Akino, H | 1 |
| Gobara, M | 1 |
| Okada, K | 1 |
| Hatano, A | 1 |
| Takahashi, H | 1 |
| Tamaki, M | 1 |
| Komeyama, T | 1 |
| Koizumi, T | 1 |
| Takeda, M | 1 |
| Chess-Williams, R | 2 |
| Aston, N | 1 |
| Couldwell, C | 2 |
| Low, AM | 1 |
| Bowdish, DM | 1 |
| Prashad, TR | 1 |
| Gaspar, V | 1 |
| Jackson, A | 1 |
| O'Brien, H | 1 |
| Oriowo, MA | 4 |
| Lepor, H | 1 |
| Tang, R | 1 |
| Shapiro, E | 1 |
| Sayet, I | 1 |
| Neuilly, G | 1 |
| Rakotoarisoa, L | 1 |
| Mironneau, C | 1 |
| Mironneau, J | 1 |
| O'Rourke, M | 1 |
| Kearns, S | 1 |
| Docherty, JR | 1 |
| Hiraoka, Y | 2 |
| Sakamoto, S | 1 |
| Hayashi, H | 1 |
| Noguera, MA | 1 |
| Ivorra, MD | 1 |
| D'Ocon, P | 1 |
| Gao, H | 1 |
| Korthuis, RJ | 1 |
| Benoit, JN | 1 |
| Tognarini, DP | 1 |
| Moulds, RF | 1 |
| Hu, XQ | 1 |
| Bricola, A | 1 |
| Tong, YC | 1 |
| Cheng, JT | 1 |
| Vivas, NM | 1 |
| Giraldo, J | 1 |
| Tabernero, A | 1 |
| Vila, E | 1 |
| Badia, A | 1 |
| Yousif, M | 1 |
| Kadavil, EA | 1 |
| Xu, K | 1 |
| Lu, Z | 1 |
| Wei, H | 1 |
| Zhang, Y | 1 |
| Han, C | 2 |
| Maruyama, K | 1 |
| Suzuki, M | 1 |
| Tsuchiya, M | 1 |
| Makara, Y | 1 |
| Hattori, K | 1 |
| Ohnuki, T | 1 |
| Watanabe, K | 1 |
| Nagatomo, T | 1 |
| Watanabe, Y | 1 |
| Morikawa, K | 1 |
| Nagata, O | 1 |
| Kato, H | 1 |
| Taniguchi, T | 1 |
| Kocić, I | 1 |
| Silva, MA | 1 |
| Megale, A | 1 |
| Porto, CS | 1 |
| Pennefather, JN | 1 |
| Lau, WA | 1 |
| Chin, C | 1 |
| Story, ME | 1 |
| Utz, J | 1 |
| Ziegler, M | 1 |
| Kapur, H | 3 |
| Green, PN | 2 |
| Butler, M | 1 |
| Jenkinson, DH | 1 |
| Takayanagi, I | 3 |
| Koike, K | 1 |
| Satoh, M | 2 |
| Sette, M | 1 |
| Bevan, RD | 1 |
| Bevan, JA | 1 |
| Kojima, C | 1 |
| Synetos, D | 1 |
| Manolopoulos, VG | 1 |
| Atlas, D | 1 |
| Pipili-Synetos, E | 1 |
| Moriya, M | 1 |
| Li, J | 1 |
| Minneman, KP | 1 |
| Suzuki, E | 2 |
| Tsujimoto, G | 2 |
| Tamura, K | 1 |
| Hashimoto, K | 2 |
| Piloni, MG | 1 |
| Honda, K | 1 |
| Takenaka, T | 1 |
| Miyata-Osawa, A | 1 |
| Terai, M | 1 |
| Shiono, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases With Benign Prostatic Hyperplasia[NCT03144596] | Phase 4 | 63 participants (Actual) | Interventional | 2015-10-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for wb 4101 and Muscle Contraction
| Article | Year |
|---|---|
[Transition of drug receptor mechanisms].
Topics: Animals; Calcium; Carbachol; Dioxanes; Muscle Contraction; Phenylephrine; Pilocarpine; Propylbenzily | 1992 |
60 other studies available for wb 4101 and Muscle Contraction
| Article | Year |
|---|---|
Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxane (WB-4101), a potent competitive alpha-adrenergic antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dioxins; In Vitro Techniques; Male; Molecular Confo | 1979 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Chemical Phenomena; Chemistry; Clonidine; Diox | 1988 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male; Muscle Contra | 1993 |
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; CHO Cells; Clonin | 1999 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; CHO Cells; Chromans; Cricetinae; Dioxanes; H | 2002 |
1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor An | 2003 |
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Aminoacridines; Animals; Aorta, Thoracic; CHO Ce | 2003 |
Functional alpha1-adrenergic receptor subtypes in human right gastroepiploic artery.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Aged; Dioxanes; Female; Gastroepiploic Artery; Human | 2003 |
Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens.
Topics: Animals; Castration; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Male; Muscle Contraction | 2003 |
Excitatory alpha1-adrenergic receptors predominate over inhibitory beta-receptors in rabbit dorsal detrusor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationsh | 2003 |
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Topics: Adrenergic alpha-Agonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Heterotrimeric GTP-B | 2004 |
Alpha1L-adrenoceptors mediate contractions of the isolated mouse prostate.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 2006 |
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes.
Topics: Acetyl-CoA C-Acyltransferase; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptak | 2006 |
Structural requirements for competitive alpha-adrenoceptor occupancy by cyclic and opened analogues of WB 4101.
Topics: Animals; Binding, Competitive; Dioxanes; Dioxins; In Vitro Techniques; Male; Muscle Contraction; Mus | 1982 |
Regulation of the alpha-adrenergic system in rat vas deferens.
Topics: Adrenergic alpha-Antagonists; Animals; Cycloheximide; Dioxanes; Male; Muscle Contraction; Norepineph | 1982 |
Noradrenergic-mediated potentiation of acetylcholine release from the phrenic nerve: evidence for presynaptic alpha 1-adrenoceptor involvement.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; In Vitro Techniques; Male | 1982 |
Pre-junctional alpha 2-adrenoceptor activity of B-HT920.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Dioxanes; Drug Interactions; Guinea Pigs; I | 1983 |
Synthesis and pharmacological evaluation of some WB4101 analogues bearing a naphthodioxanic nucleus.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; | 1984 |
Alpha 1-adrenoceptor subtypes in the human prostate.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aminoquinolines; Dioxanes; Dose-Response Rela | 1994 |
Pharmacological characterization of alpha 1-adrenoceptor subtypes in the human prostate: functional and binding studies.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Clonidine; Dioxanes; Dose-Response Relationship, | 1994 |
Pharmacological evidence of distinct alpha 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery.
Topics: Aged; Aged, 80 and over; Arteries; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Humans; In | 1994 |
Alpha 1A-adrenoceptor subtype mediates contraction of the rat urethra.
Topics: Aminoquinolines; Animals; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; | 1994 |
Interactions of chloroethylclonidine with rauwolscine- and prazosin-sensitive adrenoceptors in dog saphenous vein.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Calcium; Calcium Chan | 1994 |
Characterization of the alpha 1-adrenoceptors of the rat prostate gland.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; C | 1993 |
Alpha 1-adrenoceptor subtype(s) mediating noradrenaline-induced contractions of the guinea-pig aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1994 |
The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Binding, Competitive; Clonidine; Dioxanes; Do | 1993 |
Relation between alpha 1-adrenoceptor subtypes and noradrenaline-induced contraction in rat portal vein smooth muscle.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Clonidine; Dioxanes; Horses | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; | 1995 |
Identification of alpha 1-adrenoceptor subtypes in the rabbit prostate.
Topics: Acetonitriles; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Male; Muscle C | 1995 |
Functional evidence of inverse agonism in vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Anta | 1996 |
Hypoxia/reoxygenation selectively impairs alpha 1b-adrenoceptor function in small mesenteric arteries.
Topics: Adrenergic alpha-Antagonists; Aerobiosis; Animals; Catalase; Clonidine; Dioxanes; Hypoxia; In Vitro | 1996 |
Intracellular Ca2+ and contractile responses to alpha 1-adrenoceptor subtype activation in rat aortic vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima | 1997 |
Heterogeneity and complexity of alpha 1-adrenoceptors in the ovine uterine artery and umbilical vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Binding, Competitive; Ca | 1997 |
Functional study of the excitatory alpha-adrenoceptor in guinea pig ileum, in relation to the hypothesis of an atypical receptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Epinephrine; Guinea Pigs | 1997 |
Subtyping of alpha1-adrenoceptors responsible for the contractile response in the rat corpus cavernosum.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1997 |
Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of alpha1-adrenoceptors in the vas deferens of spontaneously hypertensive rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; In | 1997 |
Heterogeneity of alpha 1-adrenoceptor subtypes mediating noradrenaline-induced contractions of the rat superior mesenteric artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine Antagonists; Do | 1998 |
Alteration of alpha1-adrenoceptor subtypes in aortas of 12-month-old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Hypertension; Indoles; Male; Musc | 1998 |
Functional effects of castration on alpha1-adrenoceptors in rat vas deferens.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Castration; Clonidin | 1998 |
Discrimination of alpha1-adrenoceptor subtypes in rat aorta and prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta | 1998 |
Functional characterization of alpha1-adrenoceptor subtypes in the rabbit spleen.
Topics: Acetonitriles; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Chromones; Dioxanes | 1998 |
Binding and functional characterization of alpha1-adrenoceptor subtypes in the rat prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha- | 1999 |
Preconditioning prevents the negative inotropic action of phenylephrine in rat isolated stunned papillary muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiotonic Agents; Clonidine; Dioxanes; Female; Ischemic Pre | 1999 |
Expression and pharmacological characterization of alpha1-adrenoceptors in rat seminal vesicle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidin | 1999 |
alpha(1L)-adrenoceptors mediate noradrenaline-induced contractions of the guinea-pig prostate stroma.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1999 |
Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; | 2000 |
Receptor interaction for the alpha-antagonist WB4101 (2(N[2,6-dimethyoxyphenoxyethyl])amino-methyl-1,4-benzodioxane).
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dioxins; In Vitro Techniques; Male; Muscle Contract | 1978 |
Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci.
Topics: Adrenergic alpha-Antagonists; Animals; Cecum; Clonidine; Dioxanes; Dioxins; Guinea Pigs; In Vitro Te | 1978 |
Further studies on receptor interaction for the alpha-antagonist WB 4101.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dioxins; Drug Interactions; In Vitro Techniques; Ma | 1979 |
The interaction of WB4101, and other alpha-adrenoceptor antagonists, on 5-hydroxytryptamine receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Biogenic Amines; Dioxanes; Dioxins; In Vitro Techniques; Male | 1979 |
Increased density of alpha-adrenoceptors in vas deferens of spontaneously hypertensive rats (SHR), indicated by functional and receptor binding studies.
Topics: Animals; Barium; Barium Compounds; Chlorides; Dioxanes; Hypertension; Male; Muscle Contraction; Nore | 1992 |
Vascular alpha-adrenoceptor affinity variation is not due to varying populations of subtypes distinguished by WB 4101 and chlorethylclonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dioxanes; Fem | 1992 |
Pharmacological characterization of contractile responses induced by alpha 1-agonists, norepinephrine and clonidine, by selective antagonists of their subtypes in rabbit thoracic aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Competiti | 1992 |
Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood; Brain; Clonidine; Dioxanes; Female; In Vitro Te | 1991 |
Alpha 1A-adrenoceptors in rabbit bronchus.
Topics: Adrenergic alpha-Antagonists; Animals; Bronchi; Clonidine; Dioxanes; In Vitro Techniques; Male; Musc | 1991 |
Subtypes of alpha 1-adrenoceptors in rat blood vessels.
Topics: Animals; Aorta, Thoracic; Blood Vessels; Clonidine; Dioxanes; In Vitro Techniques; Male; Mesenteric | 1990 |
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Binding Sites; Calcium; Clonidine; Dioxanes; In Vitro | 1990 |
Different desensitization mechanisms of two alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; In Vitro Techniques; Muscle Contr | 1990 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 2. Role of the amine function on alpha-adrenoreceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cocaine; Dioxanes; Electric Stimulation; In Vitro | 1990 |
Studies on YM-12617: a selective and potent antagonist of postsynaptic alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Brain; Brimonidine Tartrate; Clonidine | 1985 |