wb 4101 has been researched along with Hypertension in 14 studies
N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride (KCl) and nifedipine of aortae from SHRSP and control (Wistar-Kyoto) WKY rats of different age groups (young: 3-5 weeks, and adult: 13-16 weeks)." | 3.69 | The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ( Iwanov, V; Jiang, GC; Moulds, RF, 1995) |
| "To study potential cardiac alpha 1-adrenoceptor changes in the stage of established hypertension, [3H]prazosin binding characteristics and norepinephrine (NE) stimulated production of inositol phosphates in the ventricular tissue of spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto control rats (WKY) were determined." | 3.68 | Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats. ( Badia, A; Gascón, S; Ivorra, D; Vila, E, 1993) |
| "To study potential cardiac receptor alterations during the development of spontaneous hypertension, specific binding of [3H]-2-N(2,6-dimethoxyphenoxyethyl)amino-methyl-1,4-benzodioxane, (-)-[3H]dihydroalprenolol and (-)-[3H]quinuclidinyl benzilate in ventricles of Wistar Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) at different ages was determined." | 3.67 | Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. ( Hayashi, E; Hayashi, M; Ishima, T; Okada, T; Tomita, T; Yamada, S, 1984) |
| " On the other hand, the KD and Bmax of the alpha 2-sites, measured by [3H]yohimbine binding, were reduced in SHR as compared to WKY animals, even at 4 weeks after birth when hypertension was not yet apparent." | 3.67 | Changes in the alpha-adrenoceptors in the medulla oblongata including nucleus tractus solitarii of spontaneously hypertensive rats. ( Nagata, Y; Nomura, M; Ohtsuji, M, 1985) |
| "Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients." | 2.44 | Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents. ( Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jain, KS | 1 |
| Bariwal, JB | 1 |
| Kathiravan, MK | 1 |
| Phoujdar, MS | 1 |
| Sahne, RS | 1 |
| Chauhan, BS | 1 |
| Shah, AK | 1 |
| Yadav, MR | 1 |
| Gheyouche, R | 1 |
| Le Fur, G | 1 |
| Colotte, O | 1 |
| Burgevin, MC | 1 |
| Uzan, A | 1 |
| Hellstrand, K | 1 |
| Engel, J | 1 |
| Harris, A | 1 |
| Swamy, VC | 1 |
| Triggle, DJ | 1 |
| Waters, DH | 1 |
| Wirz-Justice, A | 1 |
| Kräuchi, K | 1 |
| Campbell, IC | 1 |
| Feer, H | 1 |
| Yamada, S | 1 |
| Ishima, T | 1 |
| Tomita, T | 1 |
| Hayashi, M | 1 |
| Okada, T | 1 |
| Hayashi, E | 1 |
| McCaughran, JA | 1 |
| Edwards, E | 1 |
| Schechter, N | 1 |
| Friedman, R | 1 |
| Jiang, GC | 2 |
| Iwanov, V | 2 |
| Moulds, RF | 2 |
| Ivorra, D | 1 |
| Gascón, S | 1 |
| Vila, E | 1 |
| Badia, A | 1 |
| Luther, HP | 1 |
| Homuth, V | 1 |
| Wallukat, G | 1 |
| Xu, K | 1 |
| Lu, Z | 1 |
| Wei, H | 1 |
| Zhang, Y | 1 |
| Han, C | 1 |
| Caricati-Neto, A | 1 |
| Sette, M | 1 |
| Jurkiewicz, A | 1 |
| Nomura, M | 1 |
| Ohtsuji, M | 1 |
| Nagata, Y | 1 |
1 review available for wb 4101 and Hypertension
| Article | Year |
|---|---|
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 2008 |
13 other studies available for wb 4101 and Hypertension
| Article | Year |
|---|---|
Evidence of an increase in brain postsynaptic alpha 1-receptors in spontaneously hypertensive rats.
Topics: Aging; Animals; Brain; Dihydroalprenolol; Dioxanes; Hypertension; Kinetics; Male; Rats; Receptors, A | 1980 |
Locomotor activity and catecholamine receptor binding in adult normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Brain Stem; Cerebral Cortex; Dioxanes; Hypertension; H | 1980 |
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In | 1980 |
Adrenoceptor changes in spontaneous hypertensive rats: a circadian approach.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Brain Stem; Cerebral Cortex; Circadian | 1983 |
Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Dihydroalprenolol; Dioxanes; Heart Ventricles; Hyperte | 1984 |
Alpha 1- and alpha 2-adrenoceptor binding in the Dahl rat model of hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Cerebral Cortex; Clonidine; Dioxanes; | 1984 |
Increased sensitivity to inhibition by nifedipine of responses of the mesenteric artery bed of the SHRSP to noradrenaline is not dependent on alpha 1-adrenoceptor subtypes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1995 |
Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Ventricles; Hypertension; Inositol | 1993 |
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In | 1995 |
Alpha 1-adrenergic receptor antibodies in patients with primary hypertension.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Anta | 1997 |
Alteration of alpha1-adrenoceptor subtypes in aortas of 12-month-old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Hypertension; Indoles; Male; Musc | 1998 |
Increased density of alpha-adrenoceptors in vas deferens of spontaneously hypertensive rats (SHR), indicated by functional and receptor binding studies.
Topics: Animals; Barium; Barium Compounds; Chlorides; Dioxanes; Hypertension; Male; Muscle Contraction; Nore | 1992 |
Changes in the alpha-adrenoceptors in the medulla oblongata including nucleus tractus solitarii of spontaneously hypertensive rats.
Topics: Animals; Dioxanes; Dopamine; Hypertension; Kinetics; Medulla Oblongata; Norepinephrine; Rats; Rats, | 1985 |