wb 4101 has been researched along with Blood Pressure, High in 14 studies
N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride (KCl) and nifedipine of aortae from SHRSP and control (Wistar-Kyoto) WKY rats of different age groups (young: 3-5 weeks, and adult: 13-16 weeks)." | 3.69 | The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ( Iwanov, V; Jiang, GC; Moulds, RF, 1995) |
| "To study potential cardiac alpha 1-adrenoceptor changes in the stage of established hypertension, [3H]prazosin binding characteristics and norepinephrine (NE) stimulated production of inositol phosphates in the ventricular tissue of spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto control rats (WKY) were determined." | 3.68 | Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats. ( Badia, A; Gascón, S; Ivorra, D; Vila, E, 1993) |
| "To study potential cardiac receptor alterations during the development of spontaneous hypertension, specific binding of [3H]-2-N(2,6-dimethoxyphenoxyethyl)amino-methyl-1,4-benzodioxane, (-)-[3H]dihydroalprenolol and (-)-[3H]quinuclidinyl benzilate in ventricles of Wistar Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) at different ages was determined." | 3.67 | Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. ( Hayashi, E; Hayashi, M; Ishima, T; Okada, T; Tomita, T; Yamada, S, 1984) |
| " On the other hand, the KD and Bmax of the alpha 2-sites, measured by [3H]yohimbine binding, were reduced in SHR as compared to WKY animals, even at 4 weeks after birth when hypertension was not yet apparent." | 3.67 | Changes in the alpha-adrenoceptors in the medulla oblongata including nucleus tractus solitarii of spontaneously hypertensive rats. ( Nagata, Y; Nomura, M; Ohtsuji, M, 1985) |
| "Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients." | 2.44 | Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents. ( Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jain, KS | 1 |
| Bariwal, JB | 1 |
| Kathiravan, MK | 1 |
| Phoujdar, MS | 1 |
| Sahne, RS | 1 |
| Chauhan, BS | 1 |
| Shah, AK | 1 |
| Yadav, MR | 1 |
| Gheyouche, R | 1 |
| Le Fur, G | 1 |
| Colotte, O | 1 |
| Burgevin, MC | 1 |
| Uzan, A | 1 |
| Hellstrand, K | 1 |
| Engel, J | 1 |
| Harris, A | 1 |
| Swamy, VC | 1 |
| Triggle, DJ | 1 |
| Waters, DH | 1 |
| Wirz-Justice, A | 1 |
| Kräuchi, K | 1 |
| Campbell, IC | 1 |
| Feer, H | 1 |
| Yamada, S | 1 |
| Ishima, T | 1 |
| Tomita, T | 1 |
| Hayashi, M | 1 |
| Okada, T | 1 |
| Hayashi, E | 1 |
| McCaughran, JA | 1 |
| Edwards, E | 1 |
| Schechter, N | 1 |
| Friedman, R | 1 |
| Jiang, GC | 2 |
| Iwanov, V | 2 |
| Moulds, RF | 2 |
| Ivorra, D | 1 |
| Gascón, S | 1 |
| Vila, E | 1 |
| Badia, A | 1 |
| Luther, HP | 1 |
| Homuth, V | 1 |
| Wallukat, G | 1 |
| Xu, K | 1 |
| Lu, Z | 1 |
| Wei, H | 1 |
| Zhang, Y | 1 |
| Han, C | 1 |
| Caricati-Neto, A | 1 |
| Sette, M | 1 |
| Jurkiewicz, A | 1 |
| Nomura, M | 1 |
| Ohtsuji, M | 1 |
| Nagata, Y | 1 |
1 review available for wb 4101 and Blood Pressure, High
| Article | Year |
|---|---|
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 2008 |
13 other studies available for wb 4101 and Blood Pressure, High
| Article | Year |
|---|---|
Evidence of an increase in brain postsynaptic alpha 1-receptors in spontaneously hypertensive rats.
Topics: Aging; Animals; Brain; Dihydroalprenolol; Dioxanes; Hypertension; Kinetics; Male; Rats; Receptors, A | 1980 |
Locomotor activity and catecholamine receptor binding in adult normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Brain Stem; Cerebral Cortex; Dioxanes; Hypertension; H | 1980 |
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In | 1980 |
Adrenoceptor changes in spontaneous hypertensive rats: a circadian approach.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Brain Stem; Cerebral Cortex; Circadian | 1983 |
Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Dihydroalprenolol; Dioxanes; Heart Ventricles; Hyperte | 1984 |
Alpha 1- and alpha 2-adrenoceptor binding in the Dahl rat model of hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Cerebral Cortex; Clonidine; Dioxanes; | 1984 |
Increased sensitivity to inhibition by nifedipine of responses of the mesenteric artery bed of the SHRSP to noradrenaline is not dependent on alpha 1-adrenoceptor subtypes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1995 |
Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Ventricles; Hypertension; Inositol | 1993 |
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In | 1995 |
Alpha 1-adrenergic receptor antibodies in patients with primary hypertension.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Anta | 1997 |
Alteration of alpha1-adrenoceptor subtypes in aortas of 12-month-old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clonidine; Dioxanes; Hypertension; Indoles; Male; Musc | 1998 |
Increased density of alpha-adrenoceptors in vas deferens of spontaneously hypertensive rats (SHR), indicated by functional and receptor binding studies.
Topics: Animals; Barium; Barium Compounds; Chlorides; Dioxanes; Hypertension; Male; Muscle Contraction; Nore | 1992 |
Changes in the alpha-adrenoceptors in the medulla oblongata including nucleus tractus solitarii of spontaneously hypertensive rats.
Topics: Animals; Dioxanes; Dopamine; Hypertension; Kinetics; Medulla Oblongata; Norepinephrine; Rats; Rats, | 1985 |