Page last updated: 2024-11-05

wb 4101 and Aging

wb 4101 has been researched along with Aging in 12 studies

N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Functional correlates of alpha1-adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl."3.70Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation. ( Campos-Mello, C; Correa, FM; de Oliveira, AM; Leitão, MC, 1998)
" In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride (KCl) and nifedipine of aortae from SHRSP and control (Wistar-Kyoto) WKY rats of different age groups (young: 3-5 weeks, and adult: 13-16 weeks)."3.69The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ( Iwanov, V; Jiang, GC; Moulds, RF, 1995)
"To study potential cardiac receptor alterations during the development of spontaneous hypertension, specific binding of [3H]-2-N(2,6-dimethoxyphenoxyethyl)amino-methyl-1,4-benzodioxane, (-)-[3H]dihydroalprenolol and (-)-[3H]quinuclidinyl benzilate in ventricles of Wistar Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) at different ages was determined."3.67Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. ( Hayashi, E; Hayashi, M; Ishima, T; Okada, T; Tomita, T; Yamada, S, 1984)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's5 (41.67)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coccurello, R1
Bielawski, A1
Zelek-Molik, A1
Vetulani, J1
Kowalska, M1
D'Amato, FR1
Nalepa, I1
Gheyouche, R1
Le Fur, G1
Colotte, O1
Burgevin, MC1
Uzan, A1
Harris, A1
Swamy, VC1
Triggle, DJ1
Waters, DH1
Felder, RA1
Pelayo, JC1
Calcagno, PL1
Eisner, GM1
Jose, PA1
Yamada, S1
Ishima, T1
Tomita, T1
Hayashi, M1
Okada, T1
Hayashi, E1
Nyquist-Battie, C1
Fortney, R1
Gochee, A1
Kawai, M1
Sakaue, T1
Watanabe, C1
Nomura, Y1
Segawa, T1
Tanaka, H1
Manita, S1
Matsuda, T1
Adachi, M1
Shigenobu, K1
Jiang, GC1
Iwanov, V1
Moulds, RF1
Gascón, S1
Dierssen, M1
Màrmol, F1
Vivas, NM1
Badia, A1
de Oliveira, AM1
Campos-Mello, C1
Leitão, MC1
Correa, FM1
Villalobos-Molina, R1
Miyamoto, A1
Kowatch, MA1
Roth, GS1

Other Studies

12 other studies available for wb 4101 and Aging

ArticleYear
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Jan-03, Volume: 48

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Apoptosis; Brain; Cyclin D1; Dioxanes; Fema

2014
Evidence of an increase in brain postsynaptic alpha 1-receptors in spontaneously hypertensive rats.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:5

    Topics: Aging; Animals; Brain; Dihydroalprenolol; Dioxanes; Hypertension; Kinetics; Male; Rats; Receptors, A

1980
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
    Journal of autonomic pharmacology, 1980, Volume: 1, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In

1980
Alpha-adrenoceptors in the developing kidney.
    Pediatric research, 1983, Volume: 17, Issue:2

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Cell Membrane;

1983
Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:2

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Dihydroalprenolol; Dioxanes; Heart Ventricles; Hyperte

1984
Adrenoreceptor development in rat cerebrum and the effects of ionizing radiation.
    Brain research bulletin, 1984, Volume: 12, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Body Weight; Brain; Dioxanes; Kineti

1984
Specific binding of [3H]WB 4101, [3H]clonidine and [3H]dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats.
    Japanese journal of pharmacology, 1984, Volume: 36, Issue:2

    Topics: Aging; Alprenolol; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Female

1984
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
    British journal of pharmacology, 1995, Volume: 114, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine;

1995
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In

1995
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:10

    Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Di

1993
Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation.
    Pharmacology, 1998, Volume: 57, Issue:6

    Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta, Thoracic; Carotid Arterie

1998
Alpha 1-adrenoceptors in parotid cells: age does not alter the ratio of alpha 1A and alpha 1B subtypes.
    European journal of pharmacology, 1992, Jun-05, Volume: 226, Issue:2

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Dioxanes; Epinephrine; In Vitro Te

1992