wb 4101 has been researched along with Aging in 12 studies
N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Functional correlates of alpha1-adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl." | 3.70 | Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation. ( Campos-Mello, C; Correa, FM; de Oliveira, AM; Leitão, MC, 1998) |
| " In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride (KCl) and nifedipine of aortae from SHRSP and control (Wistar-Kyoto) WKY rats of different age groups (young: 3-5 weeks, and adult: 13-16 weeks)." | 3.69 | The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ( Iwanov, V; Jiang, GC; Moulds, RF, 1995) |
| "To study potential cardiac receptor alterations during the development of spontaneous hypertension, specific binding of [3H]-2-N(2,6-dimethoxyphenoxyethyl)amino-methyl-1,4-benzodioxane, (-)-[3H]dihydroalprenolol and (-)-[3H]quinuclidinyl benzilate in ventricles of Wistar Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) at different ages was determined." | 3.67 | Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. ( Hayashi, E; Hayashi, M; Ishima, T; Okada, T; Tomita, T; Yamada, S, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coccurello, R | 1 |
| Bielawski, A | 1 |
| Zelek-Molik, A | 1 |
| Vetulani, J | 1 |
| Kowalska, M | 1 |
| D'Amato, FR | 1 |
| Nalepa, I | 1 |
| Gheyouche, R | 1 |
| Le Fur, G | 1 |
| Colotte, O | 1 |
| Burgevin, MC | 1 |
| Uzan, A | 1 |
| Harris, A | 1 |
| Swamy, VC | 1 |
| Triggle, DJ | 1 |
| Waters, DH | 1 |
| Felder, RA | 1 |
| Pelayo, JC | 1 |
| Calcagno, PL | 1 |
| Eisner, GM | 1 |
| Jose, PA | 1 |
| Yamada, S | 1 |
| Ishima, T | 1 |
| Tomita, T | 1 |
| Hayashi, M | 1 |
| Okada, T | 1 |
| Hayashi, E | 1 |
| Nyquist-Battie, C | 1 |
| Fortney, R | 1 |
| Gochee, A | 1 |
| Kawai, M | 1 |
| Sakaue, T | 1 |
| Watanabe, C | 1 |
| Nomura, Y | 1 |
| Segawa, T | 1 |
| Tanaka, H | 1 |
| Manita, S | 1 |
| Matsuda, T | 1 |
| Adachi, M | 1 |
| Shigenobu, K | 1 |
| Jiang, GC | 1 |
| Iwanov, V | 1 |
| Moulds, RF | 1 |
| Gascón, S | 1 |
| Dierssen, M | 1 |
| Màrmol, F | 1 |
| Vivas, NM | 1 |
| Badia, A | 1 |
| de Oliveira, AM | 1 |
| Campos-Mello, C | 1 |
| Leitão, MC | 1 |
| Correa, FM | 1 |
| Villalobos-Molina, R | 1 |
| Miyamoto, A | 1 |
| Kowatch, MA | 1 |
| Roth, GS | 1 |
12 other studies available for wb 4101 and Aging
| Article | Year |
|---|---|
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Apoptosis; Brain; Cyclin D1; Dioxanes; Fema | 2014 |
Evidence of an increase in brain postsynaptic alpha 1-receptors in spontaneously hypertensive rats.
Topics: Aging; Animals; Brain; Dihydroalprenolol; Dioxanes; Hypertension; Kinetics; Male; Rats; Receptors, A | 1980 |
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In | 1980 |
Alpha-adrenoceptors in the developing kidney.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Cell Membrane; | 1983 |
Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Dihydroalprenolol; Dioxanes; Heart Ventricles; Hyperte | 1984 |
Adrenoreceptor development in rat cerebrum and the effects of ionizing radiation.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Body Weight; Brain; Dioxanes; Kineti | 1984 |
Specific binding of [3H]WB 4101, [3H]clonidine and [3H]dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats.
Topics: Aging; Alprenolol; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Female | 1984 |
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine; | 1995 |
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In | 1995 |
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Di | 1993 |
Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation.
Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta, Thoracic; Carotid Arterie | 1998 |
Alpha 1-adrenoceptors in parotid cells: age does not alter the ratio of alpha 1A and alpha 1B subtypes.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Dioxanes; Epinephrine; In Vitro Te | 1992 |