way-362450 has been researched along with Atherosclerosis* in 1 studies
1 other study(ies) available for way-362450 and Atherosclerosis
Article | Year |
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Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).
Azepino[4,5-b]indoles have been identified as potent agonists of the farnesoid X receptor (FXR). In vitro and in vivo optimization has led to the discovery of 6m (XL335, WAY-362450) as a potent, selective, and orally bioavailable FXR agonist (EC(50) = 4 nM, Eff = 149%). Oral administration of 6m to LDLR(-/-) mice results in lowering of cholesterol and triglycerides. Chronic administration in an atherosclerosis model results in significant reduction in aortic arch lesions. Topics: Administration, Oral; Animals; Aorta, Thoracic; Atherosclerosis; Azepines; Cholesterol; Disease Models, Animal; DNA-Binding Proteins; Drug Discovery; Indoles; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Transcription Factors; Triglycerides | 2009 |