way-133537 and Hypertrophy

way-133537 has been researched along with Hypertrophy* in 1 studies

Other Studies

1 other study(ies) available for way-133537 and Hypertrophy

Article	Year
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers. Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10 We have discovered a novel series of N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl] amides that are potent openers of K(ATP) channels and investigated structure-activity relationships (SAR) around the 1,2-disubstituted naphthyl core. A-151892, a prototype compound of this series, was found to be a potent and efficacious potassium channel opener in vitro in transfected Kir6.2/SUR2B cells and pig bladder strips. Additionally, A-151892 was found to selectively inhibit unstable bladder contractions in vivo in an obstructed rat model of myogenic bladder function Topics: Amides; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cell Line; Fluorescent Dyes; Humans; Hypertrophy; Male; Membrane Potentials; Muscle Contraction; Naphthalenes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Receptors; Swine; Transfection; Urinary Bladder	2003

Article

Year

Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.

Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

We have discovered a novel series of N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl] amides that are potent openers of K(ATP) channels and investigated structure-activity relationships (SAR) around the 1,2-disubstituted naphthyl core. A-151892, a prototype compound of this series, was found to be a potent and efficacious potassium channel opener in vitro in transfected Kir6.2/SUR2B cells and pig bladder strips. Additionally, A-151892 was found to selectively inhibit unstable bladder contractions in vivo in an obstructed rat model of myogenic bladder function

Topics: Amides; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cell Line; Fluorescent Dyes; Humans; Hypertrophy; Male; Membrane Potentials; Muscle Contraction; Naphthalenes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Receptors; Swine; Transfection; Urinary Bladder

2003