warfarin and Retinal-Artery-Occlusion

Antiphospholipid syndrome is a rare cause of ocular vaso-occlusive disease, but is associated with significant systemic morbidity and mortality. Thus, early diagnosis and treatment is essential.. Although the pathophysiology of antiphospholipid syndrome continues to be poorly understood, there has been continued progress with regard to the relationship between antiphospholipid antibody and its target, β-2-glycoprotein I. Due to numerous limitations with standard serologic evaluation, new approaches to the evaluation of patient serum are being considered. New guidelines for the treatment and management of antiphospholipid antibody syndrome have been established by the 13th International Committee on Antiphospholipid Antibodies.. A better understanding of the pathophysiology behind antiphospholipid antibody syndrome has led to novel approaches in the diagnosis and treatment of this disease.

Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; beta 2-Glycoprotein I; Humans; Hydroxychloroquine; Retinal Artery Occlusion; Retinal Vein Occlusion; Warfarin

A 22-year-old-lady presented with multiple occlusions of the branches of the central retinal artery, accompanied by neuro-encephalic disorders and deafness. This triad is known as SICRET Syndrome (Small Infarction of Cochlear, Retinal and Encephalic Tissue). This rare syndrome, as well referred to as Susac syndrome, affects only the women and the three tissues mentioned above: eye, ear, brain. The course was characterised by a series of partially regressive evolutive steps. A remission had been obtained since two years with immuno-supressor and anti-coagulant therapy. The neuro-encephalic and cochlear disorder regressed in contrast to the severe sequel on the right eye.

Topics: Adult; Anticoagulants; Arterioles; Cerebral Infarction; Cochlea; Deafness; Diagnosis, Differential; Drug Therapy, Combination; Female; Headache; Humans; Immunosuppressive Agents; Infarction; Magnetic Resonance Imaging; Organ of Corti; Prednisolone; Retinal Artery Occlusion; Salicylic Acid; Syndrome; Vertigo; Vision Disorders; Warfarin

Central retinal artery occlusion (CRAO) is a devastating ocular emergency characterized by acute painless visual loss in the ipsilateral eye. We describe the case of acute non-arteritic CRAO associated fusiform internal carotid-ophthalmic artery aneurysm with intraluminal thrombus. Despite the rarity of this condition, we suggest that carotid-ophthalmic artery aneurysm should be included in the differential diagnosis of CRAO.

Topics: Adult; Anticoagulants; Blindness; Carotid Artery Diseases; Carotid Artery, Internal; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Ophthalmic Artery; Retinal Artery Occlusion; Warfarin

Topics: Anticoagulants; Blindness; Echocardiography, Doppler, Color; Heart Defects, Congenital; Humans; Male; Middle Aged; Retinal Artery Occlusion; Visual Acuity; Visual Fields; Warfarin

Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Anticoagulants; Antiphospholipid Syndrome; Bevacizumab; Drug Therapy, Combination; Enoxaparin; Female; Fluorescein Angiography; Glucocorticoids; Humans; Intraocular Pressure; Laser Coagulation; Middle Aged; Retinal Artery Occlusion; Retinal Vasculitis; Uveitis, Anterior; Visual Acuity; Warfarin

Topics: Anticoagulants; Atrial Fibrillation; Diagnosis, Differential; Electrocardiography, Ambulatory; Female; Humans; Middle Aged; Retinal Artery Occlusion; Visual Acuity; Warfarin

A 79-year-old right-handed woman was admitted to hospital following sudden onset of severe visual loss in the left eye. Left central retinal artery occlusion (CRAO) was diagnosed. Diffusion-weighted imaging showed an asymptomatic hyperintensity in left middle cerebral artery territory. Transcranial Doppler and transesophageal echocardiography revealed patent foramen ovale. No other embolic sources were identified in the carotid artery, aortic arch, or heart. We report herein a case of CRAO caused by paradoxical brain embolism.

Topics: Aged; Anticoagulants; Cerebral Angiography; Contrast Media; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Electrocardiography; Embolism, Paradoxical; Female; Humans; Intracranial Embolism; Retinal Artery Occlusion; Ultrasonography, Doppler, Transcranial; Warfarin

Topics: Adult; Anticoagulants; Carotid Artery, Internal; Carotid Stenosis; Coronary Angiography; Drug Therapy, Combination; Eye; Female; Fluorescein Angiography; Heparin, Low-Molecular-Weight; Humans; Ischemia; Retinal Artery Occlusion; Scleroderma, Diffuse; Syndrome; Ultrasonography, Doppler; Warfarin

Topics: Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Ciliary Arteries; Fluorescein Angiography; Functional Laterality; Humans; Male; Middle Aged; Retinal Artery Occlusion; Visual Acuity; Warfarin

Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Female; Fluorescein Angiography; Humans; Platelet Aggregation Inhibitors; Retinal Artery Occlusion; Retinal Vein Occlusion; Visual Acuity; Warfarin

To investigate a case of a young woman with both primary antiphospholipid syndrome and factor V Leiden mutation who developed multiple retinal arteriolar occlusions.. Case report of a 25-year-old woman with history and laboratory tests confirming the diagnosis of both primary antiphospholipid syndrome and factor V Leiden mutation who presented with blurred vision in both eyes.. Multiple retinal arteriolar occlusions were observed in both of her eyes. The patient was treated first with heparin and then with warfarin.. Primary antiphospholipid syndrome and factor V Leiden mutation, as well as other forms of thrombophilia, should be considered in the differential diagnosis of unexplained retinal vascular occlusions. The coexistence of several thrombophilic disorders may carry a particularly high risk for thrombotic manifestations.

Topics: Activated Protein C Resistance; Adult; Antiphospholipid Syndrome; Arterioles; Factor V; Female; Fluorescein Angiography; Heparin; Humans; Point Mutation; Retinal Artery Occlusion; Warfarin

To report two cases of head or neck pain and central retinal artery occlusion associated with spontaneous dissection of the ipsilateral internal carotid artery.. Case reports.. We describe two cases of sudden visual loss caused by central retinal artery occlusion. Both cases were preceded by ipsilateral headaches or neck pain and tinnitus. The patient had no other neurological signs or history of trauma. In both cases, cerebral angiography revealed ipsilateral internal carotid artery dissection.. Ipsilateral headache or neck pain with tinnitus preceding central retinal artery occlusion is highly suggestive of internal carotid artery dissection. Early diagnosis and treatment may reduce the risk of hemispheric stroke.

Topics: Adult; Carotid Artery, Internal, Dissection; Cerebral Angiography; Female; Headache; Heparin; Humans; Middle Aged; Neck Pain; Retinal Artery Occlusion; Visual Acuity; Warfarin

A case of central retinal artery occlusion in a patient with Marfan's syndrome secondary to possible thromboembolism from a prolapsed mitral valve is presented. Clinical investigations and treatment of this condition are discussed. The world literature on retinal occlusive events secondary to mitral valve prolapse is briefly summarised. To the best of our knowledge, this is the first case report in the literature of central retinal artery occlusion in a patient with Marfan's syndrome.

Topics: Adult; Female; Fluorescein Angiography; Fundus Oculi; Humans; Marfan Syndrome; Mitral Valve Prolapse; Retinal Artery Occlusion; Thromboembolism; Warfarin

A 34-year-old woman is presented who has recurrent, multiple, retinal arteriolar occlusions associated with a deficiency in protein C, a vitamin K-dependent anticoagulant. Protein C is a naturally occurring anticoagulant and if there is a deficiency, it can lead to episodes of thrombosis; the deficiency can be acquired or congenital. This is the first documented case of retinal arteriolar occlusion associated with a congenital deficiency of this protein. The mechanism for arteriolar occlusion in this patient is discussed, and whilst the role of protein C deficiency remains presumptive, it is strongly implicated.

Topics: Adult; Arterioles; Female; Fluorescein Angiography; Fundus Oculi; Humans; Intraocular Pressure; Migraine Disorders; Pregnancy; Pregnancy Complications; Protein C Deficiency; Recurrence; Retinal Artery Occlusion; Thrombosis; Visual Acuity; Visual Fields; Warfarin