warfarin and Respiratory-Distress-Syndrome

Topics: Aged, 80 and over; Anticoagulants; Drug Overdose; Erythrocyte Transfusion; Fatal Outcome; Female; Hemorrhage; Humans; Lung Diseases; Pulmonary Alveoli; Pulmonary Edema; Respiratory Distress Syndrome; Respiratory Insufficiency; Warfarin

When 'catastrophic' is applied as an adjective to the antiphospholipid syndrome, it implies a characteristic presentation due to predominantly small blood vessel thrombosis leading to rapidly progressive failure of multiple organs and a frequently fatal outcome. We present the case of a 48-year-old woman who presented with the 'catastrophic' antiphospholipid syndrome without previous history of coagulation disorder or connective tissue disease that illustrates the difficulties in diagnosing and managing this disorder. We also review the factors that have been reported to have a role in the development of this condition and show how this case throws light on its pathogenesis.

Topics: Anti-Inflammatory Agents; Anticoagulants; Antiphospholipid Syndrome; Antirheumatic Agents; Critical Illness; Female; Humans; Hydroxychloroquine; Methylprednisolone; Middle Aged; Prednisolone; Respiratory Distress Syndrome; Treatment Outcome; Warfarin; White People

Topics: Adult; Animals; Blood Coagulation Factors; Female; Heparin; Humans; Male; Middle Aged; Pulmonary Embolism; Rabbits; Respiratory Distress Syndrome; Urokinase-Type Plasminogen Activator; Warfarin