warfarin and Porphyrias

warfarin has been researched along with Porphyrias* in 2 studies

Reviews

2 review(s) available for warfarin and Porphyrias

ArticleYear
Enzyme induction by drugs. Its relevance to clinical biochemistry.
    Annals of clinical biochemistry, 1978, Volume: 15, Issue:1

    The properties of the hepatic microsomal, drug detoxicating, enzyme system are reviewed with particular reference to its inducibility. Induction is modified by various factors of which the diet is particularly important. A theoretical model system for induction has been proposed and this is discussed. There are a number of methods for assessing microsomal enzyme induction in man, none of which is ideal. Nevertheless, induction is a well recognized phenomenon in man and has a bearing on the metabolism of a number of endogenous substances. The effect of induction on steroid metabolism and the relationship between inducers, vitamin D, and metabolic bone disease is discussed. Bilirubin metabolism is affected by changes in microsomal enzyme activity and inducers have been used therapeutically in some cases of hyperbilirubinaemia. The relationship between drugs and the hepatic porphyrias is reviewed. The hepatic microsomal enzyme system is but one of many inducible enzymes and the role of induction in general in metabolic regulation is emphasised.

    Topics: Animals; Bilirubin; Carcinogens; Chemistry, Clinical; Enzyme Induction; Half-Life; Humans; Inactivation, Metabolic; Liver; Microsomes; Pharmaceutical Preparations; Pharmacology; Porphyrias; Public Health; Steroids; Warfarin

1978
The actions and interactions of drugs: the therapeutic significance of enzyme induction.
    Transactions of the St. John's Hospital Dermatological Society, 1967, Volume: 53, Issue:1

    Topics: Aging; Animals; Child; Chloral Hydrate; Dogs; Drug Antagonism; Drug Resistance, Microbial; Endoplasmic Reticulum; Enzyme Induction; Female; Genetics, Microbial; Griseofulvin; Humans; Hypnotics and Sedatives; Infant, Newborn; Insecticides; Lupus Erythematosus, Systemic; Male; Mice; Microscopy, Electron; Microsomes; Molecular Biology; Penicillinase; Phenobarbital; Porphyrias; Rabbits; Rats; Steroids; Warfarin

1967