warfarin and Muscular-Dystrophy--Duchenne

A 31-year-old man with Duchenne muscular dystrophy was admitted to our center, having infarctions in bilateral cerebral hemispheres and an occluded right middle cerebral artery. His right middle cerebral artery was spontaneous recanalization on the next day, and thrombus in the left ventricle vanished on the eighth day after giving warfarin.

Topics: Adult; Anticoagulants; Cerebral Infarction; Heart Diseases; Heart Ventricles; Humans; Male; Muscular Dystrophy, Duchenne; Thrombosis; Warfarin

We report cerebral embolism in 2 patients with Duchenne muscular dystrophy (DMD) after respiratory tract infection. A 31-year-old man (Case 1) was admitted to the hospital because of an upper respiratory tract infection, then suddenly developed left-sided hemiparesis. Transthoracic echocardiography revealed an intracardiac thrombus in the left ventricle, and, under assumption of cardioembolic stroke, oral anticoagulation was initiated. Case 2 was a 36-year-old man who developed dysphasia after increasing sputum. Based on brain CT scan findings, we confirmed a diagnosis of cerebral infarction. There was no recurrence in either case. Both cases developed cerebral infarction due to embolism after mild upper respiratory tract infections. DMD patients have various risk factors for thrombus and embolus, while physicians should also be aware of possible cerebral infarction and other coagulation disorders irrespective of respiratory and cardiac therapy.

Topics: Adult; Anticoagulants; Aspirin; Brain; Diffusion Magnetic Resonance Imaging; Echocardiography; Heart Diseases; Heart Ventricles; Heparin; Humans; Intracranial Embolism; Magnetic Resonance Angiography; Male; Muscular Dystrophy, Duchenne; Respiratory Tract Infections; Risk; Thrombosis; Tomography, X-Ray Computed; Treatment Outcome; Warfarin