warfarin and Migraine-Disorders

Topics: Anticoagulants; Aspirin; Balloon Occlusion; Decision Making; Decompression Sickness; Heart Septal Defects, Atrial; Humans; Migraine Disorders; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Warfarin

Topics: Adult; Aged; Basophils; Blood Cell Count; Clofibrate; Female; Hematuria; Heparin; Humans; Immunoglobulins; Injections, Intravenous; Lipids; Male; Middle Aged; Migraine Disorders; Warfarin

Topics: Accident Prevention; Aged; Anti-Bacterial Agents; Anticoagulants; Carbamazepine; Dibenzazepines; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Evaluation Studies as Topic; Female; Humans; Length of Stay; Male; Middle Aged; Migraine Disorders; Pharmaceutical Preparations; Phenobarbital; Placebos; Warfarin

We report on a 14-year-old girl presenting with an acute headache syndrome that developed after intake of contraceptive drug. Laboratory values showed a homozygous mutation of factor V Leiden and we treated her initially with heparin, then with coumadin. There were no complications during the course of treatment. Interestingly, the initial headache responded well to therapy with sumatriptan, so it is assumed as a first manifestaion of migraine and this delayed the actually diagnosis. Imaging studies showed extensive cerebral venous sinus thrombosis. However, the patient had no focal deficits.. Wir berichten über ein 14-jähriges Mädchen mit einem akuten Kopfschmerzsyndrom unter Einnahme von einem Kontrazeptivum, das ausgedehnte zerebrale Sinusvenenthrombose hat. Laborchemisch zeigte sich ein Nachweis einer homozygoten Faktor-V-Leiden-Mutation. Die initiale Behandlung erfolgte mit Heparin mit anschließender Umstellung auf Coumadin. Der Verlauf blieb komplikationslos. Interessant war in diesem Fall erstens, dass die initialen Kopfschmerzen gut auf Sumatriptan angesprochen haben, was sich die Diagnose verspätet feststellen ließ, mit der Annahme einer möglichen Erstmanifestation einer Migräne, zweitens, dass trotz dem stark ausgedehnten bildmorphologischen Befund die Patientin ohne fokale neurologische Defizite blieb.

Topics: Adolescent; Delayed Diagnosis; Factor V; Female; Heparin; Humans; Migraine Disorders; Mutation; Sinus Thrombosis, Intracranial; Sumatriptan; Warfarin

Topics: Humans; Migraine Disorders; Migraine with Aura; Pyrazoles; Pyridones; Topiramate; Warfarin

We examined the influence of catheter ablation and periprocedural anticoagulation regimen on trajectory of migraine in atrial fibrillation patients with or without migraine history.. Forty patients with (group 1: 64 ± 8 years; men 78%) and 85 (group 2: 61 ± 10 years; men 73%) without migraine history undergoing atrial fibrillation-ablation were enrolled. Migraine status and quality of life were evaluated using standardized questionnaires. Diffusion magnetic resonance imaging of brain was performed for all at pre and 24 hours post procedure. Catheter ablation was performed with (88, 70%) or without (37, 30%) continuous warfarin treatment. Fifty-four patients (11 and 43 from groups 1 and 2, respectively) had subtherapeutic international normalized ratio on procedure day. At 17 ± 5 months follow-up, from group 1, 25 (63%) reported no migraine, 10 (25%) had < 1, and 3 (8%) had 2 to 3 monthly symptoms. Intensity of pain decreased from baseline 7 (Q1-Q3, 4-8) to 2 (0-4) scale points at follow-up (P < 0.001) and duration of headache from median 8 (Q1-Q3, 4-15) to 0.5 (Q1-Q3, 0-2) hours (P < 0.001). Two patients from group 1 reported increased migraine severity and 2 from group 2 had new-onset migraine. Follow-up diffusion magnetic resonance imaging revealed new infarcts in 9.6% (12/125) patients; of which 11 had subtherapeutic preprocedural international normalized ratio on or off continuous warfarin. Quality of life improved significantly in patients with successful ablation, being more pronounced in group 1.. In most patients, migraine symptoms improved substantially after catheter ablation. Interestingly, the only cases of new migraine and aggravation of pre-existent headache had subtherapeutic international normalized ratio during the procedure and new cerebral infarcts.

Topics: Aged; Anticoagulants; Atrial Fibrillation; Catheter Ablation; Diffusion Magnetic Resonance Imaging; Drug Administration Schedule; Female; Humans; International Normalized Ratio; Male; Middle Aged; Migraine Disorders; Predictive Value of Tests; Prospective Studies; Quality of Life; Recurrence; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome; Warfarin

Topics: Anticoagulants; Atrial Fibrillation; Catheter Ablation; Female; Humans; Male; Migraine Disorders; Warfarin

We report the case of a patient suffering from migraine with and without aura who had a complete remission of both during warfarin treatment for pulmonary embolism; the attacks reappeared promptly during two treatment withdrawals. We highlight warfarin as prophylactic drug in migraine prophylaxis and discuss about new, safer and more specific anticoagulants that could be used in migraine treatment. Their use could also clarify literature's conflicting data about anticoagulants' efficacy in migraine prophylaxis and clear if their efficacy in migraine treatment could be related aspecifically to anticoagulation's effect or to a particular mechanism in the coagulation cascade.

Topics: Adult; Anticoagulants; Female; Humans; Migraine Disorders; Pulmonary Embolism; Warfarin

Topics: Arthritis, Rheumatoid; Aspirin; Drug Interactions; Gastrointestinal Diseases; Humans; Hypersensitivity; Migraine Disorders; Oral Ulcer; Phytotherapy; Plant Preparations; Randomized Controlled Trials as Topic; Tanacetum parthenium; Warfarin

Topics: Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Female; Humans; Middle Aged; Migraine Disorders; Warfarin

Topics: Adrenal Cortex Hormones; Adult; Anemia, Hemolytic, Autoimmune; Biopsy, Needle; Diagnosis, Differential; Follow-Up Studies; Giant Cell Arteritis; Glomerulosclerosis, Focal Segmental; Headache; Humans; Intracranial Hypertension; Male; Migraine Disorders; Sleep Apnea Syndromes; Vision Disorders; Warfarin

This article presents the case of a healthy 46-year-old man who experienced a dissection of the internal carotid artery. The diagnosis of this condition is not usually clear-cut, especially in a young patient with unremarkable medical history, and because of the similarity of symptoms with migraine. Often there is no obvious cause of a cerebral artery dissection, although subtle abnormalities of connective tissue may be present. Anticoagulation is generally used for therapy, but clinical trials are lacking. Carotid artery dissection should be considered as a cause of stroke in young healthy adults.

Topics: Anticoagulants; Carotid Artery, Internal, Dissection; Cerebral Angiography; Cerebral Infarction; Diagnosis, Differential; Horner Syndrome; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Migraine Disorders; Physical Therapy Modalities; Stroke; Warfarin

Topics: Anticoagulants; Hemostasis; Humans; Migraine Disorders; Vasoconstrictor Agents; Vasopressins; Warfarin

A patient suffering from migraine, whose symptoms were abolished by warfarin therapy, is reported. Warfarin was prescribed for deep vein thrombosis and the frequency of the patient's headache improved remarkably during the anticoagulant therapy. Because of the unusual nature of the response to anticoagulant therapy, warfarin was reintroduced on a double blind (versus placebo) basis and once again abolished the headaches.

Topics: Aged; Double-Blind Method; Female; Humans; Migraine Disorders; Thrombophlebitis; Warfarin

We describe a test for LA based on the specific APTT behaviour of LA plasmas when the incubation time with the APTT reagent is increased from 1 to 20 min. "1-10 APTT" test was defined as the difference (s) between results of the APTT performed with 1 and the one performed with 10 min incubation. A test value > 11 s (upper normal limit determined on 134 normal plasmas) was considered positive for a LA. The test distinguished all the LA patients studied (n = 40) from patients with factor VIIIc inhibitors, patients receiving heparin or warfarin therapy and also patients with congenital factor deficiencies, except those with prekallikrein and factor XII deficiencies. The test detected LA in warfarin (n = 3) and in heparin (n = 2) LA anticoagulated patients. Among 195 patients referred for LA screening, the test detected LA in 5 patients with normal standard APTT. This simple test, using a single reagent for screening and confirmatory procedures is sensitive and fairly specific for LA when combined with mixing studies. However, since the test was defined using one APTT reagent, the performances of other reagents have to be assessed.

Topics: Abortion, Habitual; Female; Heparin; Humans; Lupus Coagulation Inhibitor; Lupus Erythematosus, Systemic; Migraine Disorders; Partial Thromboplastin Time; Pregnancy; Sensitivity and Specificity; Time Factors; Warfarin

A 34-year-old woman is presented who has recurrent, multiple, retinal arteriolar occlusions associated with a deficiency in protein C, a vitamin K-dependent anticoagulant. Protein C is a naturally occurring anticoagulant and if there is a deficiency, it can lead to episodes of thrombosis; the deficiency can be acquired or congenital. This is the first documented case of retinal arteriolar occlusion associated with a congenital deficiency of this protein. The mechanism for arteriolar occlusion in this patient is discussed, and whilst the role of protein C deficiency remains presumptive, it is strongly implicated.

Topics: Adult; Arterioles; Female; Fluorescein Angiography; Fundus Oculi; Humans; Intraocular Pressure; Migraine Disorders; Pregnancy; Pregnancy Complications; Protein C Deficiency; Recurrence; Retinal Artery Occlusion; Thrombosis; Visual Acuity; Visual Fields; Warfarin

Topics: Adult; Humans; Male; Migraine Disorders; Thrombophlebitis; Warfarin

Topics: Administration, Oral; Anticoagulants; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelets; Cerebral Arteries; Dose-Response Relationship, Drug; Heparin; Humans; Leg; Migraine Disorders; Thrombophlebitis; Vasodilator Agents; Warfarin