warfarin and Hypersensitivity

Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Drug Contamination; Drug Monitoring; Food-Drug Interactions; Hemorrhage; Heparin; Humans; Hypersensitivity; Injections, Subcutaneous; Necrosis; Osteoporosis; Skin Diseases; Subcutaneous Tissue; Thrombocytopenia; Warfarin

Topics: Arthritis, Rheumatoid; Aspirin; Drug Interactions; Gastrointestinal Diseases; Humans; Hypersensitivity; Migraine Disorders; Oral Ulcer; Phytotherapy; Plant Preparations; Randomized Controlled Trials as Topic; Tanacetum parthenium; Warfarin

Our aim was to review the safety of percutaneous injection laryngoplasty using bovine crosslinked collagen, focusing specifically on two often-stated concerns: injecting patients who are taking the anticoagulant medication warfarin, and injecting patients without prior skin hypersensitivity testing.. Retrospective chart review of injection laryngoplasty performed between 1997 and 2006 at the University of California, Los Angeles.. The study group consisted of 895 patients who underwent 1290 injection laryngoplasty procedures. No bleeding complications were noted in 59 patients taking warfarin. No allergic complications were reported in 845 patients who did not undergo skin hypersensitivity testing before injection laryngoplasty.. Percutaneous bovine crosslinked collagen injection laryngoplasty is safe in patients taking warfarin. Skin testing for hypersensitivity does not appear to be necessary before injection.. Patients on warfarin are candidates for injection laryngoplasty without the need to discontinue the medication. Eliminating skin hypersensitivity testing before percutaneous bovine crosslinked collagen injection laryngoplasty allows for a prompt treatment of glottic insufficiency.

Topics: Aged; Animals; Anticoagulants; Biocompatible Materials; Cattle; Collagen; Female; Glottis; Humans; Hypersensitivity; Injections, Intradermal; Laryngeal Diseases; Male; Postoperative Complications; Postoperative Hemorrhage; Prostheses and Implants; Retrospective Studies; Safety; Vocal Cord Paralysis; Voice Disorders; Warfarin

Topics: Allergens; Cystitis; Drug Hypersensitivity; Eosinophilic Granuloma; Female; Humans; Hypersensitivity; Male; Middle Aged; Nitrofurantoin; Prednisolone; Urography; Warfarin

Topics: Adolescent; Carcinoma, Hepatocellular; Diagnosis, Differential; Female; Humans; Hypersensitivity; Liver Neoplasms; Necrosis; Skin Diseases; Thigh; Thrombophlebitis; Warfarin

Using intravenous sodium warfarin, rabbits were rendered hypoprothrombinemic and subjected to two intravenous injections of Shear's polysaccharide. None of the 9 animals surviving the required period of time developed bilateral renal cortical necrosis or histologic thrombi in the kidney, liver, spleen, or lungs. In a control group of 7 animals treated only with endotoxin, 6 developed bilateral renal cortical necrosis. It is concluded that the prothrombin complex is necessary for the production of the generalized Shwartzman reaction by bacterial endotoxins and that this phenomenon is essentially a process of disseminated intravascular coagulation.

Topics: Animals; Coumarins; Disseminated Intravascular Coagulation; Endotoxins; Hypersensitivity; Kidney; Necrosis; Rabbits; Shwartzman Phenomenon; Sodium; Thrombosis; Warfarin