warfarin and Diseases-in-Twins

Topics: Alcohol Oxidoreductases; Catalase; Cholinesterases; Dicumarol; Diseases in Twins; Drug Hypersensitivity; Drug Resistance; Drug-Related Side Effects and Adverse Reactions; Environment; Female; Genetic Diseases, Inborn; Glaucoma; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Infant, Newborn; Intraocular Pressure; Isoniazid; Malignant Hyperthermia; Mutation; Pharmaceutical Preparations; Pharmacogenetics; Phenylthiourea; Phenytoin; Pregnancy; Protein Binding; Racial Groups; Warfarin

Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; Cyanides; Dicumarol; Diseases in Twins; Drug Hypersensitivity; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Isoniazid; Liver; Male; Metabolism, Inborn Errors; Middle Aged; Pharmacogenetics; Phenylbutazone; Phenylthiourea; Phenytoin; Pregnancy; Primaquine; Twins; Warfarin

We describe a pair of twins, whose mother was being treated by oral anticoagulant drugs, as a result of having received mitral heart valve implantation in the past. The male twins monochorionic, monoamniotic--but one infant showed the features of fetal warfarin syndrome. In the study we discussed the pharmacogentetics and individual variation in the human metabolism during treatment with warfarin-perinatal growth and prevalence of congenital malformations. We analysed the threats to the fetus and mother, connected with administration of anticoagulant drugs.

Topics: Abnormalities, Multiple; Adult; Anticoagulants; Diseases in Twins; Female; Fetal Death; Humans; Infant, Newborn; Male; Mitral Valve Insufficiency; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Exposure Delayed Effects; Twins; Warfarin

Topics: Diseases in Twins; Eye Diseases; Heterozygote; Homozygote; Humans; Infant, Newborn; Infant, Premature; Male; Ocular Physiological Phenomena; Protein C; Protein C Deficiency; Time Factors; Warfarin

Topics: Anticoagulants; Blood; Blood Coagulation Factors; Blood Coagulation Tests; Child; Coumarins; Dicumarol; Diseases in Twins; Drug Tolerance; Genetics, Medical; Geriatrics; Heparin; Humans; Intestinal Absorption; Pharmacology; Phenindione; Vitamin K; Warfarin