warfarin and Diabetic-Ketoacidosis

Venous thromboembolism is a rarely described complication of diabetic ketoacidosis (DKA). We describe a 21-year-old male patient with poorly controlled type 1 diabetes mellitus who was admitted with DKA, presumably secondary to noncompliance, whose clinical picture was complicated by generalized thrombosis involving multiple venous locations including renal vein, pulmonary vasculature, external iliac and common iliac veins. The patient had no family history of any coagulation disorders and a hypercoagulabilty work-up remained negative. The patient was subsequently anticoagulated with heparin and discharged home on warfarin. To the best of our knowledge, this is the first reported case of multiple venous thromboses occurring as a complication of DKA with no other risk factors. We also reiterate that although rare, venous thrombosis should always be considered as a potential complication of DKA.

Topics: Anticoagulants; Diabetic Ketoacidosis; Heparin; Humans; Iliac Vein; Male; Patient Compliance; Pulmonary Veins; Renal Veins; Risk Factors; Venous Thrombosis; Warfarin; Young Adult

Topics: Computer-Assisted Instruction; Computers; Diabetic Coma; Diabetic Ketoacidosis; Diagnosis, Computer-Assisted; Education, Medical; Education, Medical, Undergraduate; Insulin; Massachusetts; Models, Theoretical; Programmed Instructions as Topic; Students, Medical; Warfarin