warfarin and Deafness

Warfarin embryopathy is a well-defined manifestation of intrauterine warfarin exposure. The embryopathy phenotype as it relates to the nervous system is broad and poorly recognised. We describe an adult with neurological sequelae of fetal warfarin exposure. We review previous cases with neurological sequelae and discuss the pathogenetic mechanism in light of recent research.

Topics: Abnormalities, Drug-Induced; Adult; Anticoagulants; Cognition Disorders; Deafness; Humans; Male; Nasal Bone; Spinal Cord Diseases; Spine; Warfarin

A 22-year-old-lady presented with multiple occlusions of the branches of the central retinal artery, accompanied by neuro-encephalic disorders and deafness. This triad is known as SICRET Syndrome (Small Infarction of Cochlear, Retinal and Encephalic Tissue). This rare syndrome, as well referred to as Susac syndrome, affects only the women and the three tissues mentioned above: eye, ear, brain. The course was characterised by a series of partially regressive evolutive steps. A remission had been obtained since two years with immuno-supressor and anti-coagulant therapy. The neuro-encephalic and cochlear disorder regressed in contrast to the severe sequel on the right eye.

Topics: Adult; Anticoagulants; Arterioles; Cerebral Infarction; Cochlea; Deafness; Diagnosis, Differential; Drug Therapy, Combination; Female; Headache; Humans; Immunosuppressive Agents; Infarction; Magnetic Resonance Imaging; Organ of Corti; Prednisolone; Retinal Artery Occlusion; Salicylic Acid; Syndrome; Vertigo; Vision Disorders; Warfarin

A case is presented of sudden deafness following cardio-pulmonary bypass surgery. Microembolism is believed to be the most likely cause as this is common following the use of pump oxygenator systems. There was no response to anticoagulants.

Topics: Animals; Aortic Valve Stenosis; Cardiopulmonary Bypass; Deafness; Extracorporeal Circulation; Heparin; Humans; Male; Middle Aged; Postoperative Complications; Warfarin

Topics: Acute Disease; Administration, Oral; Adult; Carbon Dioxide; Child, Preschool; Cortisone; Deafness; Dextrans; Diet Therapy; Dimenhydrinate; Female; Hearing Tests; Heparin; Histamine; Humans; Injections, Intravenous; Middle Aged; Nicotinic Acids; Propantheline; Time Factors; Vasodilator Agents; Warfarin