warfarin and Blood-Protein-Disorders

Analbuminemia (idiopathic hypoalbuminemia) is a rare congenital anomaly of albumin characterised by very low levels of this protein. Only 21 cases have been reported in the literature. The lack of albumin is "compensated" by increased amounts of various circulating plasma proteins. Other not well understood regulatory mechanisms are responsible for the absence of severe clinical consequences. Clinical aspects, genetics and pathophysiology of this disease are discussed.

Topics: Adolescent; Adult; Blood Protein Disorders; Blood Proteins; Child; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diazepam; Female; Fibrinogen; Glomerular Filtration Rate; Half-Life; Humans; Infusions, Parenteral; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Protein Binding; Renin; Serum Albumin; Transferrin; Warfarin

Necrotizing skin lesions developed in a man with chronic ulcerative colitis. No evidence of intrinsic disease of medium or small-sized vessels was found. A circulating cryofibrinogen was thought to be responsible for in situ thrombosis leading to skin infarctions. Sodium warfarin in a daily dose of 2.5 to 5 mg appears to have thwarted progression of developing lesions and the occurrence of new ones.

Topics: Blood Protein Disorders; Chronic Disease; Cold Temperature; Colitis, Ulcerative; Fibrinogen; Humans; Male; Middle Aged; Necrosis; Skin Diseases; Warfarin

Topics: Angiography; Blood Protein Disorders; Blood Proteins; Cholesterol; Headache; Humans; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Skin Diseases; Syndrome; Warfarin