warfarin and Anemia--Hypochromic

Topics: Adult; Anemia, Hypochromic; Anticoagulants; Heart Valve Prosthesis; Hematoma; Humans; Male; Mesocolon; Peritoneal Diseases; Warfarin

The difficulty in the treatment of patients undergoing Warfarin therapy for mitral stenosis, is underlined and cases treated with Danazol in sideropenic anaemia caused by menometrorrhagia are reported.

Topics: Anemia, Hypochromic; Danazol; Drug Evaluation; Drug Interactions; Female; Heart Valve Prosthesis; Humans; Menorrhagia; Mitral Valve; Mitral Valve Stenosis; Pregnadienes; Warfarin

Observations on the interactions of cadmium (Cd) x aflatoxin B1 (AFB1) and Cd x warfarin included several variables of animal performance and hematology. Cadmium was fed daily for 40 days (groups IV, V, VI) and a Cd-free diet was fed to groups I, II, and III. Groups II and V were treated with AFB1, and groups III and VI were treated with warfarin--each for 5 days during the 5th week of the experiment and the effects were observed for 10 days. All pigs fed the diet with added Cd had developed severe anemia by the 4th week of the experiment. The incorporation of this toxic concentration of Cd (83 micrograms/g) in the diet seemed to have blocked the liver microsomal enzyme system (cytochrome P-450), diminishing the toxic effects of 5 daily oral doses (0.2 mg/kg of body wt) of AFB1 (group V pigs), but enhancing synergistically the toxic anticoagulant effects of the same doses of warfarin in young pigs (group VI). The data presented also indicated that the feeding of toxic concentrations of Cd stimulated increased glutathione peroxidase activity, which conjugated the AFB1 epoxides with their excretion as reduced glutathione but enhanced the toxic anticoagulant effects of warfarin in young pigs.

Topics: Aflatoxin B1; Aflatoxins; Anemia, Hypochromic; Animal Feed; Animals; Cadmium; Carcinogens; Drug Synergism; Leukocyte Count; Male; Swine; Swine Diseases; Warfarin

Topics: Adult; Anemia, Hypochromic; Female; Half-Life; Humans; Thrombophlebitis; Warfarin

Size-frequency distribution curves of erythrocytes were generated with the Coulter Counter in 73 normal subjects and patients. Mean corpuscular volume (MCV) determined by routine calculation and MCV determined by size-frequency distribution were similar in all normal subjects and in patients with a single population of erythrocytes. Some patients with iron-deficiency anemia, folate deficiency, and vitamin B12 deficiency had two discrete erythrocyte populations. Some patients with microcytic anemia were shown to have a population of normocytes in addition to the predominant microcytic population. Reticulocytes and normocytes were identified in two patients recovering from macrocytic anemia. Transfused blood was identified as a separate population in a patient with microcytic anemia. In cases with two erythrocyte populations, the MCV of the principal population, as determined from size-distribution curves, differed from the MCV of the entire erythrocyte pool, as was determined by routine methods. Analysis of sequential erythrocyte size distributions in patients under treatment demonstrated the dynamics of erythrocyte subpopulations. Anisocytosis was quantified and shown to be associated frequently with hospitalized patients.

Topics: Adenocarcinoma; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Brain Diseases; Electronics, Medical; Erythrocyte Count; Erythrocytes; Female; Folic Acid Deficiency; Heart Failure; Hematocrit; Hemorrhage; Humans; Male; Methotrexate; Middle Aged; Reticulocytes; Thrombophlebitis; Vitamin B 12 Deficiency; Warfarin